Практические Рекомендации По Лекарственному Лечению Рака Прямой Кишки

Федянин, М. Ю.; Артамонова, Е. В.; Барсуков, Ю. А.; Болотина, Л. В.; Gladkov, Oleg; Глебовская, В. В.; Гордеев, С. С.; Карачун, А. М.; Козлов, Н. А.; Любченко, Л. Н.; Малихова, О. А.; Мамедли, З. З.; Михайлов, А. И.; Подлужный, Д. В.; Protsenko, S.A. Protsenko; Рыбаков, Е. Г.; Рыков, И. В.; Самсонов, Д. В.; Сидоров, Д. В.; Снеговой, А. В.; Ткачёв, С. И.; Трякин, А. А.; Цуканов, А. С.; Черных, М. В.; Шелыгин, Ю. А.

doi:10.18027/2224-5057-2020-10-3s2-23

Cited by 3 publications

(1 citation statement)

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“…Современный стандарт лечения нижнеампулярного рака прямой кишки -комбинированное лечение с неоадъювантной химиолучевой терапией (НХЛТ) и последующей операцией [1]. Полный или почти полный ответ на НХЛТ, получаемый у рядапациентов, позволяет избежать агрессивного хирургического лечения и заменить его более щадящим, таким как трансанальная эндоскопическая микрохирургия, или даже полностью отказаться от хирургии в пользу стратегии активного наблюдения (так называемогоwach&wait), включающего регулярное пальцевое ректальное исследование, ректоскопию и магнитно-резонансную томографию (МРТ).…”

Section: обоснованиеunclassified

MRI evaluation of the neoadjuvant chemoradiation therapy result in a patient with rectal cancer, supplemented with T2-WI texture analysis of the tumor: a clinical case

Dayneko

Александровна²,

Berezovskaya

et al. 2021

Digital Diagnostics

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The article presents a clinical case of using the active follow-up strategy (the so-called watch wait) in a 73-year-old patient with cancer of the lower rectum with a good response to neoadjuvant chemoradiation therapy (NCRT). After 3 years of regular follow-up, including digital rectal examination, rectoscopy and MRI, indicating the absence of tumor progression, PET / CT with 18F-FDG was obtained, which revealed a region of hypermetabolic activity in the lower rectum (SUVmax = 27.1), in connection with which it was decided to carry out surgical treatment.When discussing the issue of the volume of the operation, MRI data were taken into account, supplemented by the results of T2-weighted texture analysis, which confirmed the absence of progression. The patient underwent organ-preserving treatment in the amount of transanal tumor resection. Pathomorphological examination after surgery established the inflammatory changes in the intestinal wall and absence of tumor. This case demonstrates the effectiveness of the standard examination volume when using the watch wait strategy and the possibility of using T2-WI texture analysis to increase the reliability of MRI assessment of tumor response to chemotherapy.

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Section: обоснованиеunclassified

MRI evaluation of the neoadjuvant chemoradiation therapy result in a patient with rectal cancer, supplemented with T2-WI texture analysis of the tumor: a clinical case

Dayneko

Александровна²,

Berezovskaya

et al. 2021

Digital Diagnostics

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Robot-assisted surgery for rectal cancer in patients after neoadjuvant chemoradiotherapy Immediate results

Moiseev,

Kotiv,

Gladyshev

et al. 2024

Onkol. koloproktol.

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Introduction. The benefits of robotic surgery for rectal cancer remain controversial. Only a few studies have evaluated the safety and feasibility of robot-assisted surgery after neoadjuvant chemoradiotherapy.Aim. Our study aimed to compare the short-term outcomes of robotic and traditional laparoscopic surgery after neoadjuvant chemoradiotherapy for rectal cancer.Materials and methods. This retrospective study was based on the analysis of 210 medical records of patients with rectal tumors who underwent robot-assisted and laparoscopic-assisted surgeries after neoadjuvant chemoradiotherapy from 2015 to 2021.Results. There was no significant difference in short-term outcomes such as operation time, conversion rate, anastomotic leakage, and quality of circular resection margin. However, a significant difference was noted in the quality of total mesorectal excision. Grade 3 quality in the R group was 93.9 %, while in the L group it was 74.07 % (Odds Ratio (OR) 2.335; 95 % Confidence Interval (CI) 1.107–4.925). A statistically significant difference was also found in the rate of performing sphincter-preserving procedures, with 12.2 % in the R group and 50 % in the L group (OR 0.139; 95 % CI 0.066–0.293).Conclusion. The advantages of the robotic surgical system in the surgical treatment of rectal cancer in patients after neoadjuvant chemoradiotherapy improve clinical outcomes, primarily reflected in the rate of sphincter-preserving operations. Additionally, it provides a trend towards achieving more oncologically adequate tumor removal compared to laparoscopic procedures.

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Neoadjuvant Сhemoradiotherapy of Locally Advanced Rectal Cancer with Local 5-Fluoracil Radiomodification

Ахтемзянов

Korytov

Корытова

et al. 2021

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Chemoradiotherapy, along with following surgical treatment, including total mesorectal excision, is a current standard for treatment of locally advanced rectal cancer. Neoadjuvant chemoradiotherapy allows to downsize the tumor, up to complete clinical response in one third of all cases, which, in turn, allows increase in sphincter preserving operations, disease-free period and overall survivability. Derivatives of 5-fluoracil are used as basic chemotherapeutic agents. These drugs have a substantial amount of side effects, which lead to either plan corrections, or may even prevent its completion. Thus, search for new ways to increase chemotherapy agent in the tumor cells with reduction of systemic toxicity to improve neoadjuvant chemoradiotherapy results is an acute task for modern medicine. In this article authors suggest intrarectal application of sterile hydrogel material based on sodium alginate with incorporated 5-fluoracil as a method of neoadjuvant chemoradiotherapy.

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Практические Рекомендации По Лекарственному Лечению Рака Прямой Кишки

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Cited by 3 publications

References 0 publications

MRI evaluation of the neoadjuvant chemoradiation therapy result in a patient with rectal cancer, supplemented with T2-WI texture analysis of the tumor: a clinical case

MRI evaluation of the neoadjuvant chemoradiation therapy result in a patient with rectal cancer, supplemented with T2-WI texture analysis of the tumor: a clinical case

Robot-assisted surgery for rectal cancer in patients after neoadjuvant chemoradiotherapy Immediate results

Neoadjuvant Сhemoradiotherapy of Locally Advanced Rectal Cancer with Local 5-Fluoracil Radiomodification

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