Поражение Печени При Covid-19

Abstract

В обзоре обобщены новые сведения о вовлечении печени в патологический процесс при COVID-19. Новая коронавирусная инфекция, вызванная Sars Cov-2, является системным вирусным заболеванием с полиорганным поражением. По данным разных исследователей отмечается повышение активности печеночных ферментов (АЛТ, АСТ) от 25% до 46%, при этом степень поражения печени коррелирует с тяжестью, развитием ОРДС и исходом заболевания у больных COVID-19.

Patients with chronic liver disease and COVID-19 (literature review and own data)

“…[2,4,17]. The pathogenetic COVID-19 is characterized by viremia, local and systemic immune-inflammatory processes, hyperactivity of the coagulation cascade, endothelial disease, hypoxia, which leads to the development of micro-and macrothrombosis; proceeds from asymptomatic to clinically severe forms with intoxication, fever, damage to the vascular endothelium, lungs, heart, kidneys, gastrointestinal tract, central and peripheral nervous system, system at risk [1,2,3,5,7,9,18,21].…”

“…During the pandemic, it became clear that COVID -19 is not just acute respiratory infection, but a disease with multiple organ systemic damage, including number of such an important organ as the liver. This issue was covered by us in special reviews [3,5,6,13,15] based on a generalization of the data available at that time literature. The liver is a vital organ with multiple functions.…”

“…However, it is already clear that patients with severe fibrosis and cirrhosis of the liver, patients after liver transplantation are also a vulnerable group with an increased risk of infection and severe course of COVID-19. Therefore, they are strictly prescribed self-isolation and reduction of social contacts [3,5,7].…”

“…The liver is a vital organ with multiple functions. The protective function of the liver includes detoxification of endogenous and exogenous factors [1,5,7,26,27].…”