Within the framework of the previously proposed model (S.Yu. Davydov. Phys. Solid State 64, 2018 (2022)), in which the interaction of a macromolecule (MM) with single-layer graphene (SLG) is carried out by stitching of dangling MM bonds with carbon atoms, the effect of these stitching on the mobility of carriers in graphene was studied. It is shown that short-range scattering of MM-SLG stitching prevails over Coulomb scattering. It has also been found that the effect of induced by stitching graphene deformation on mobility can be neglected compared to short-range scattering. The cases of free and epitaxial graphene are considered. The use of the MM-SLG-substrate structure as the basis of a biosensor is discussed.