Повышение концентрации белка sEH в мозговом веществе почек крыс линии НИСАГ с наследуемой, индуцируемой стрессом, артериальной гипертензией, "Молекулярная биология"

Абрамова, Т. О.; Ryazanova, M. A.; Antonov, E. V.; Redina, Olga E.; Markel, A. L.

doi:10.7868/s0026898417020021

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…By using a gene microarray analysis, Seubert et al (2005) reported that sEH was significantly upregulated in the kidneys of spontaneously hypertensive rats (SHR) when compared with the non-hypertensive Wistar-Kyoto (WKY) rats. Also, Abramova et al (2013, 2017) found that the renal mRNA level and protein concentration of sEH were increased at in the inherited stress-induced arterial hypertension (ISIAH) rats when compared with the normative Wistar Albino Glaxo (WAG) rats. Tain et al (2015) reported that renal sEH was upregulated in dexamethasone- and a high fructose-induced rodent model of programmed hypertension.…”

Section: Preclinical Studies Of the Treatment Of Renal Dysfunction Bymentioning

confidence: 99%

Inhibition of Soluble Epoxide Hydrolase for Renal Health

Liu

2019

Front. Pharmacol.

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A soluble epoxide hydrolase (sEH) mediates the metabolism of epoxy fatty acids to form the corresponding vicinal diols, which are usually inactive or less active than the epoxide substrates. The sEH enzyme presents in many organs, including but not limited to the liver, heart, spleen, lung, and kidney. Here we summarized the changes in the expression and activity of sEH in multiple renal diseases, such as acute kidney injury (AKI), diabetic nephrology (DN), chronic kidney diseases (CKD), hypertension-mediated renal damage, and other renal dysfunctions. We also discussed the pharmacologic effects and the underlying mechanisms of sEH inhibition by using an inhibitor of sEH and/or the generic deletion of sEH on multiple renal diseases. We believe that sEH is a potential therapeutic target for renal dysfunction although the target disease needs further investigation.

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Section: Preclinical Studies Of the Treatment Of Renal Dysfunction Bymentioning

confidence: 99%

Inhibition of Soluble Epoxide Hydrolase for Renal Health

Liu

2019

Front. Pharmacol.

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Stress, Genes, and Hypertension. Contribution of the ISIAH Rat Strain Study

Redina

Markel

2018

Curr Hypertens Rep

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Recent findings helped to characterize the main neuroendocrine mechanisms and the specificity of the genetic background contributing to the stress-sensitive hypertension development in the ISIAH rats. The ISIAH rat strain, which is an original model of the stress-sensitive arterial hypertension, can be considered as "living" proof that the genetic predisposition to increased stress-reactivity can lead to the development of persistent stress-dependent arterial hypertension. The ISIAH rat strain is characterized by the genetically determined enhanced response of the neuroendocrine and renal regulatory systems to stress and is a suitable model that allows one to explore the genetic and physiological mechanisms involved in stress-sensitive hypertension development. There are common genetic loci (QTLs) associated with both basal and stress-induced blood pressure (BP) levels as well as QTLs associated with BP and other traits, which may be related to hypertension development in ISIAH rats. Multiple genes differentially expressed in the target organs/tissues of hypertensive ISIAH and normotensive control rats are associated with many biological processes and metabolic pathways involved in stress response and arterial hypertension. The genotype of ISIAH rats is characterized by numerous specific and common SNPs as compared with other models of hypertensive rats. The results of the studies are valuable for the search for genetic markers specific for stress-induced arterial hypertension, as well as for the selection of new molecular targets that may be potentially useful for prevention and/or therapy of hypertensive disease.

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Cited by 2 publications

References 35 publications

Inhibition of Soluble Epoxide Hydrolase for Renal Health

Inhibition of Soluble Epoxide Hydrolase for Renal Health

Stress, Genes, and Hypertension. Contribution of the ISIAH Rat Strain Study

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