Оптимизация Режима Приема Лекарственных Средств С Учетом Особенностей Хроноритма И Десинхроноза Органов Желудочно-Кишечного Тракта

Бунятян, Н. Д.; Дроговоз, С. М.; Кононенко, А. Г.; Олефир, Ю. В.; Прокофьев, А. Б.

doi:10.30906/0023-1134-2017-51-8-31-33

Cited by 2 publications

(2 citation statements)

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“…Ethical Issues. The work plan for studying the acute toxicity and irritant action of metal alloys TNT and BT-6 was developed in accordance with the guidelines outlined in the manual for conducting preclinical studies of medicinal products and medical devices [20], following the principles of the Helsinki Declaration of the World Medical Association The object of the study was the experimental alloy TNT (Ti21Nb6Ta), as well as samples of the titanium alloy BT-6 (Ti-6Al-4V) -the control group provided by the Ulbinsky Metallurgical Plant.…”

Section: Methodsmentioning

confidence: 99%

Assessment of the Biological Safety of Metal Alloys TNT (Ti21Nb6Ta) and ВТ-6 (Ti-6Al-4V)

Batpenov,

Bekarissov,

Ospanov

et al. 2023

JTO

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The introduction of modern technologies in traumatology and orthopedics, such as immersion fixators and new biometallic alloys, has led to a qualitative change in approaches to treatment, but the use of new materials in the manufacture of implants remains relevant.Purpose of the study. Study of the biocompatibility of an alloy of titanium, tantalum and niobium (Ti21Nb6Ta) in vitrо. Methods. The study examined the toxic effects of aqueous extracts of TNT (Ti21Nb6Ta) and BT-6 (Ti-6Al-4V) on human fibroblasts and periosteal cells in vitro using the MTT test; hemolytic activity of TNT and BT-6 alloys on the blood of experimental animals - Wistar rats (in vitro) by spectrophotometry; Pyrogenic activity was also studied using the kinetic chromogenic method. The object of the study is the metal alloys TNT (Ti21Nb6Ta) and BT-6 (Ti-6Al-4V) (control group).Results. In vitro studies have shown that aqueous extracts from the metal alloys TNT and BT-6 do not have a cytotoxic effect on cultured human fibroblasts and periosteal cells in vitro. It was revealed that aqueous extracts of TNT and BT-6 alloys do not have hemolytic and pyrogenic activity.Conclusions. The studies conducted indicate a high level of safety and biocompatibility of the TNT alloy, which is proven by a set of in vitro tests. Thus, according to the generally accepted hygienic classification, the metal alloys TNT (Ti21Nb6Ta) and BT-6 (Ti-6Al-4V) can be classified as hazard class 4 - low-hazard substances (GOST 12.1.007-76).

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Section: Methodsmentioning

confidence: 99%

Assessment of the Biological Safety of Metal Alloys TNT (Ti21Nb6Ta) and ВТ-6 (Ti-6Al-4V)

Batpenov,

Bekarissov,

Ospanov

et al. 2023

JTO

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“…На сегодня для этих целей применяются различные лекарственные препараты. В то же время помимо фармакотерапии при многих заболеваниях костной и соединительной тканей применяется карбокситерапия, которая в настоящее время активно внедряется в различных отраслях медицины [17][18][19][20]. В организме существует множество сенсоров, регистрирующих концентрацию углекислого газа как важнейшего продукта клеточного дыхания.…”

Section: Introductionunclassified

Use of carboxytherapy in the treatment of periodontal diseases: A preclinical experimental study

Kolsanov,

Trunin,

Khaikin

et al. 2024

Kuban. nauсh. med. vestnik

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Background. Periodontitis is a progressive lesion of periodontal tissues and one of the most important causes of tooth loss. According to recent publications, periodontitis affects from 11% to 50% of the world’s adult population. Therefore, the problem of developing effective methods for treating and preventing this disease remains relevant. Metabolic disorders in the periodontium are known to contribute to the development of periodontitis. A pronounced change in hemodynamics and microcirculation leads to trophic disturbance of periodontal tissues, thus triggering the development of pronounced hypoxia in these tissues. Thus, prevention and elimination of hypoxia is one of the most important stages of pathogenetic treatment. Objective. To experimentally evaluate the efficacy of injectable carboxytherapy in the treatment of periodontal diseases using an in vivo model of periodontitis in rats. Methods. A preclinical experimental study was conducted on 30 sexually mature Wistar rats. The animals were randomly divided into 4 groups, including I–III experimental groups (n = 27) and a control group (n = 3). In all experimental groups, periodontitis was modelled. In group I (n = 9), no treatment was performed. In group II (n = 9), carboxytherapy with a carbon dioxide flow rate of 5 ml/min was conducted. In group III (n = 9), carboxytherapy with a flow rate of 10 ml/ min was conducted. The experimental animals were injected with carbon dioxide once, twice, or three times 7 days after surgical intervention at weekly intervals. The efficacy of injected carboxytherapy in rat periodontium with respect to the control was evaluated by histologic analysis. The norm criteria were the lamellar structure of compact alveolar bone, the presence of periodontal ligament between the alveolar bone and the tooth, represented by oriented collagen fibers with orderly arranged fibroblasts between them (final signs). The intermediate outcome was considered based on the launch of neovascularization and neocollagenogenesis processes. The criterion of neovascularization and neocollagenogenesis activation was considered to be an increase in the number of young collagen fibers, an increase in fibroblast-like cells of outgrowth form with a high expression of procollagen in the connective tissue matrix (intermediate signs). Integral indices on intermediate signs and on final signs were brought to normalized indices as a fraction of the maximum possible sum of points in the group. The dynamics of the normalized indicator for intermediate and final signs was considered. The results were processed using IBM SPSS Statistics version 26 (IBM Inc., USA). Results. The histological study of the mandible of rats from group I demonstrated that the destruction of the periodontal ligament in the absence of treatment leads to the widening of the periodontal gap, accompanied by inflammatory processes and thinning of collagen fibers due to the growth of edema, the appearance of resorption lacunae and, further, to the resorption of alveolar bone. At the same time, groups II and III showed a gradual decrease in the inflammatory reaction, formation of young collagen fibers, and, as a consequence, restoration of the periodontal space. In these groups, the histologic pattern corresponded to the norm in the case of three times carboxytherapy injection with a flow rate of 5 ml/min and already in the case of two times injection with a flow rate of 10 ml/min. Conclusion. The use of injectable carboxytherapy to treat periodontal ligament lesions not only restores its microarchitectonics, but also prevents further resorption of alveolar bone. This may have a positive effect in the treatment of periodontal disease.

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Оптимизация Режима Приема Лекарственных Средств С Учетом Особенностей Хроноритма И Десинхроноза Органов Желудочно-Кишечного Тракта

Cited by 2 publications

References 0 publications

Assessment of the Biological Safety of Metal Alloys TNT (Ti21Nb6Ta) and ВТ-6 (Ti-6Al-4V)

Assessment of the Biological Safety of Metal Alloys TNT (Ti21Nb6Ta) and ВТ-6 (Ti-6Al-4V)

Use of carboxytherapy in the treatment of periodontal diseases: A preclinical experimental study

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