ОМ-85: personalized approach to the treatment of acute respiratory infections in children

Tataurschikova, N. S.

doi:10.20953/1817-7646-2020-1-61-68

Cited by 2 publications

(2 citation statements)

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“…To reduce the spread and emergence of new antibiotic-resistant strains, various approaches are being used to limit the use of antibiotics in agriculture [13,14] and medicine [15,16]. New control strategies are being developed, such as vaccines, antibodies [17,18], pattern recognition receptor ligands [19][20][21][22][23], probiotics, plant extracts [24,25], bacteriophages [26], cytokines [27], phytochemicals, silver and chitosan nanoparticles [28], antimicrobial enzymes, and peptides [29].…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation, Bioavailability and Safety of Bacteriocins

Guryanova

2023

Life

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The rise of antibiotic-resistant bacteria and the emergence of new pathogens have created a need for new strategies to fight against infectious diseases. One promising approach is the use of antimicrobial peptides produced by a certain species of bacteria, known as bacteriocins, which are active against other strains of the same or related species. Bacteriocins can help in the treatment and prevention of infectious diseases. Moreover, bacteriocins can be obtained in prokaryotic organisms, and contribute s to their widespread use. While the use of bacteriocins is currently limited to the food industry (for example, nisin is used as a preservative, E234), a large number of studies on their microbicidal properties suggest that their use in medicine may increase in the foreseeable future. However, for the successful use of bacteriocins in medicine, it is necessary to understand their effect on the immune system, especially in cases where immunity is weakened due to infectious processes, oncological, allergic, or autoimmune diseases. Studies on the immuno-modulatory activity of bacteriocins in animal models and human cells have revealed their ability to induce both pro-inflammatory and anti-inflammatory factors involved in the implementation of innate immunity. The influence of bacteriocins on acquired immunity is revealed by an increase in the number of T-lymphocytes with a simultaneous decrease in B-lymphocyte levels, which makes them attractive substances for reducing inflammation. The widespread use of bacteriocins in the food industry, their low toxicity, and their broad and narrow specificity are reasons for researchers to pay attention to their immunomodulatory properties and explore their medical applications. Inflammation regulation by bacteriocins can be used in the treatment of various pathologies. The aim of the review was to analyze scientific publications on the immunomodulatory activity, bioavailability, and safety of bacteriocins in order to use the data obtained to organize preclinical and clinical studies.

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Section: Introductionmentioning

confidence: 99%

Immunomodulation, Bioavailability and Safety of Bacteriocins

Guryanova

2023

Life

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“…Regulation of the intensity and type of the immune response depends on many factors, including readiness of the immune system to quickly and accurately recognize and respond to a pathogen. Active search is underway for compounds that prevent the development of inflammatory processes, including those from natural raw materials [4][5][6][7][8][9]. Commensal microorganisms help to keep the immune system in constant readiness for an adequate response.…”

Section: Introductionmentioning

confidence: 99%

Inflammatory response modulation by epinephrine and norepinephrine

Guryanova,

Ferberg,

Sigmatulin

2023

Vestn. Ross. univ. družby nar., Ser. Med.

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Relevance. Inflammation is a defense response of an organism to a pathogen. It appears in order to maintain homeostasis and is regulated by the immune, nervous, and endocrine systems. The hormones epinephrine and norepinephrine are produced in the adrenal medulla and in the brain, and are universal messengers that trigger the transmission of nerve impulses at synapses, and also have a receptor-mediated effect on immunocompetent cells. The aim of this study was to investigate adrenergic pathway regulation of inflammation on the neutrophil granulocytes in the presence of activators of innate immunity receptors. Materials and Methods. Neutrophil granulocytes were obtained from peripheral blood of healthy volunteers in a density gradient of Histopaque 1077 and Histopaque 1119 (Sigma Aldrich, Steinheim, Germany), and cultured in the presence of LPS, GMDP, epinephrine and norepinephrine. The amount of human neutrophil peptides 1-3 (HNP1-3) was examined using an enzyme-linked immunosorbent assay; the gene expression of TLR4, NOD2, ATF3 and A20 was determined using RT-PCR. Results and Discussion. Norepinephrine (noradrenaline) was found to decrease the synthesis of human neutrophils peptides 1-3 (HNP 1-3 defensins, alone and in the combination with agonists of TLR4 and NOD2 receptors - LPS and GMDP respectively. It was found out that there was no a statistically significant effect of epinephrine (adrenaline) on the production of HNP 1-3, including when combined with LPS and GMDP. As a result of the study, an increase in the levels of expression of the genes TLR4, NOD2 and regulator of inflammatory reactions A20 both in LPS- and GMDP- induced neutrophil culture were uncovered, while ATF3 was increased only in LPS-induced neutrophil culture. Epinephrine demonstrated the absence of a statistically significant effect on the expression of the studied genes. While norepinephrine significantly increased the expression of A20 genes. Conclusion. The data obtained shows that norepinephrine can reduce the synthesis of HNP 1-3, including the one induced by LPS and GMDP. Moreover, the ability of norepinephrine to induce the expression of A20 may play a significant role in modulation of inflammation.

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ОМ-85: personalized approach to the treatment of acute respiratory infections in children

Cited by 2 publications

References 0 publications

Immunomodulation, Bioavailability and Safety of Bacteriocins

Immunomodulation, Bioavailability and Safety of Bacteriocins

Inflammatory response modulation by epinephrine and norepinephrine

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