МЕХАНИЗМ РЕАКЦИИ ЭЛИМИНИРОВАНИЯ СЕЛЕНА В ДИАЦЕТОФЕНОНИЛСЕЛЕНИДЕ ПОД ДЕЙСТВИЕМ ВОССТАНОВЛЕННОГО ГЛУТАТИОНА, "Журнал Аналитической Химии"

Полубояринов, П А; Лещенко, П.П.; Моисеева, И. Я.; Kolesnikova, S G; Эпштейн, Н.Б.

doi:10.7868/s0044450217070118

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“…Диацетофенонилселенид (ДАФС-25, Селенобел, 1,5-дифенил-3-селенапентадион-1,5), по нашим исследованиям [38,39], в целом, имеет схожий с селенитом натрия механизм метаболизма, взаимодействуя с тиолами, например, с восстановленным глутатионом (GSH).…”

Section: серы металлический селен -самая термодинамически устойчиваяunclassified

“…Взаимодействие диацетофенонилселенида с восстановленным глутатионом представляет собой классический пример обезвреживания ксенобиотика путем нуклеофильного замещения, в результате которого образуется селеноводород и ацетофенон. Промежуточными продуктами реакции являются как S-(ацетофенилселенил)глутатион, так и селенодисульфид глутатиона [38], что дает возможность сделать предположение о наличии некоторого обменного пула для диацетофенонилселенида в биологических средах.…”

Section: рисunclassified

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Metabolism and Mechanism of Toxicity of Selenium-Containing Supplements Used for Optimizing Human Selenium Status

Poluboyarinov

Elistratov²,

Shvets

2019

Fine Chem. Tech.

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The work presents a review devoted to the metabolism and the mechanism of toxicity of seleniumcontaining supplements: elemental selenium, sodium selenite, diacetophenonyl selenide, selenopyrane, ebselen, dimethyl dipyrasolyl selenide and selenium-containing amino acids used for correction of selenium deficiency. Elemental selenium penetrating through cell walls, but not through transport channels demonstrates poorly predicted and difficultly regulated bioavailability. Sodium selenate is known to be the most toxic form of selenium in food. The metabolism of xenobiotic diacetophenonyl selenide resembles that of sodium selenide. The xenobiotic reacts with thiols, for instance, with the reduced form of glutathione leading to the formation of hydrogen selenide. Ebselen is not considered to be a well bioavailable form of selenium and thus possesses low toxicity. Xenobiotic selenopyrane eliminates selenium only in processes of xenobiotic liver exchange, and in our investigations - partially in acid-catalyzed hydrolysis. The metabolism of xenobiotic dimethyl dipyrasolyl selenide having low toxicity is poorly investigated. The toxicity of high doses of selenomethionine is determined by the possibility of incorporation in proteins and vitally important enzymes with dramatic changes of protein quaternary structure. The toxicity of high doses of methylselenocysteine seems to be caused by the lack of an exchange pool in the body and quick regeneration of hydrogen selenide from methylselenol which is formed as a result of enzymatic destruction of this amino acid. Also the issue of the most prospect selenium donor is discussed. The physiological compatibility, the low toxicity, the presence of an exchangeable pool in the organism, the antioxidantal properties and the simplicity of production indicate selenocystine as an optimal selenium donor.

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Section: серы металлический селен -самая термодинамически устойчиваяunclassified

Section: рисunclassified

Metabolism and Mechanism of Toxicity of Selenium-Containing Supplements Used for Optimizing Human Selenium Status

Poluboyarinov

Elistratov²,

Shvets

2019

Fine Chem. Tech.

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МЕХАНИЗМ РЕАКЦИИ ЭЛИМИНИРОВАНИЯ СЕЛЕНА В ДИАЦЕТОФЕНОНИЛСЕЛЕНИДЕ ПОД ДЕЙСТВИЕМ ВОССТАНОВЛЕННОГО ГЛУТАТИОНА, "Журнал Аналитической Химии"

Cited by 1 publication

References 0 publications

Metabolism and Mechanism of Toxicity of Selenium-Containing Supplements Used for Optimizing Human Selenium Status

Metabolism and Mechanism of Toxicity of Selenium-Containing Supplements Used for Optimizing Human Selenium Status

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