Латентний Автоімунний Діабет У Дорослих (LADA): Сучасний Погляд На Проблему

Pashkovska, N.V.

doi:10.22141/2224-0721.15.3.2019.172116

Cited by 4 publications

(2 citation statements)

References 46 publications

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“…Останніми роками з'явилися нові докази генетичної та фенотипової гетерогенності ЦД, яка виходить за межі двох основних класичних типів, що вказує на доцільність розробки персоніфікованих підходів до діагностики та лікування цього захворювання та його ускладнень [2]. Яскравим прикладом такої гетерогенності є латентний автоімунний діабет дорослих (LADA).…”

Section: распределение фенотипов хронической болезни почек при латентunclassified

Distribution of phynotypes of diabetic kidney disease in latent autoimmune diabetes in adults

Tsaryk¹

2020

Buk. Med. Herald

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Мета роботи-з'ясувати поширеність фенотипів діабетичної хвороби нирок при латентному автоімунному діабеті дорослих порівняно з іншими типами цукрового діабету. Матеріал і методи. Проведене комплексне обстеження 96 пацієнтів з хронічною хворобою нирок та цукровим діабетом: 40 (основна група) з латентним автоімунним діабетом дорослих (LADA), 28-із цукровим діабетом 1-го типу (ЦД 1), 28-із цукровим діабетом 2-го типу (ЦД 2)-групи порівняння. Оцінювали скарги, дані анамнезу, об'єктивного обстеження, результати загальноклінічних лабораторних досліджень, показників вуглеводного обміну, швидкість клубочкової фільтрації, альбумінурію, альбумін-креатинінове співвідношення, дані ультразвукового дослідження нирок.

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Section: распределение фенотипов хронической болезни почек при латентunclassified

Distribution of phynotypes of diabetic kidney disease in latent autoimmune diabetes in adults

Tsaryk¹

2020

Buk. Med. Herald

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“…This year, for the first time in the more than thirtyyear history of LADA, an international expert panel was held to build consensus on approaches to insulin therapy in LADA depending on the degree of C-peptide insulin deficiency [10]. At the same time, the question of the need for pathogenetic treatment to enhance insulin action is still unclear as aspects of the role of pathogenetic mechanisms of DM in the development of LADA, primarily insulin resistance, are currently insufficiently disclosed.…”

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Prevalence of risk factors of cardiometabolic complications in latent autoimmune diabetes in adults

Tsaryk

Pashkovska²,

Ilashchuk

2021

Buk. Med. Herald

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The aim of the study. To determine the prevalence of risk factors for cardiometabolic complications in latent autoimmune diabetes in adults compared to other types of diabetes depending on the phenotype of the disease.Materials and methods. A comprehensive examination of 106 patients with diabetes mellitus: 45 (main group) with latent autoimmune diabetes in adults (LADA), 26 - with type 1 diabetes mellitus (T1DM), 35 - with type 2 diabetes mellitus (T2DM). Complaints, anamnesis data, objective examination, results of general clinical, laboratory researches, indicators of carbohydrate metabolism, titers of antibodies to glutamic acid decarboxylase were evaluated.Results. The prevalence of metabolic syndrome (MS) in LADA was 51% and was significantly higher than in T1DM (19%), but was lower compared with T2DM (94%). The highest incidence of MS was found in patients with the LADA2 phenotype (87%). Of particular note is the fact that this figure was close to that in T2DM. At the same time in LADA1 the incidence of MS was lower (36%), but twice as high as in T1DM. In addition to hyperglycemia, abdominal obesity (62% of patients), hypertension (78%) and dyslipidemia (56%) were commonly reported in LADA.Conclusions. The prevalence of metabolic syndrome as a complex of cardiometabolic risk factors in LADA differs from that in classical types of diabetes, which requires a differential approach to their management.

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Latent autoimmune diabetes in adults: current data (review of literature and own data)

Pashkovska,

Tsaryk

2024

Mìžnarodnij endokrinologìčnij žurnal

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The article provides up-to-date information on latent autoimmune diabetes in adults (LADA), presents data on epidemiology, factors and mechanisms of development, clinical features of this disease. The phenotypic variants of the course of LADA are described, the issues of diagnostic features and differential diagnosis are revealed. LADA is a form of diabetes characterized by a less intense autoimmune process and a wide range of clinical signs compared to classical type 1 diabetes mellitus (T1DM) and can have features of both major types of diabetes. Based on the results of epidemiological studies, the prevalence of LADA is approximately 12 % of all cases of diabetes, it is the second most common form of diabetes after type 2 diabetes mellitus (T2DM) and is the most common type of autoimmune diabetes in adults. According to the modern classification, LADA belongs to the autoimmune subtype of T1DM. Since patients do not need insulin at the beginning of the disease, the course of LADA is similar to T2DM, which is the cause of diagnostic errors. The literature data and the results of the conducted research have shown that, in addition to autoimmune damage to pancreatic beta cells, insulin resistance plays a key role in the mechanisms of LADA development, with an increase in the frequency and degree of abdominal obesity, which not only worsens metabolic control and increases the risk of metabolic syndrome, but also causes a decrease in insulin secretion and progression of the autoimmune process. In patients with LADA, the prevalence and degree of obesity, hypertension and dyslipidemia occupy an intermediate position between the classical types of diabetes. Despite having fewer metabolic risk factors compared to T2DM, patients with LADA have the same or even higher risk of death and cardiovascular diseases. The most important diagnostic markers of LADA are levels of C-peptide and autoantibodies against islet antigens. The possibility of a clear diagnosis of LADA is limited due to the significant heterogeneity of the disease due to an overlap of T1DM and T2DM symptoms. According to modern guidelines, therapeutic approaches to LADA, which are based on insulin therapy and metformin, depend on the level of C-peptide. More research is needed to improve personalized approaches to the treatment of this disease.

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Латентний Автоімунний Діабет У Дорослих (LADA): Сучасний Погляд На Проблему

Cited by 4 publications

References 46 publications

Distribution of phynotypes of diabetic kidney disease in latent autoimmune diabetes in adults

Distribution of phynotypes of diabetic kidney disease in latent autoimmune diabetes in adults

Prevalence of risk factors of cardiometabolic complications in latent autoimmune diabetes in adults

Latent autoimmune diabetes in adults: current data (review of literature and own data)

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