Когнітивні Порушення У Осіб З Алкогольною Енцефалопатією Та Пароксизмальними Станами

Roshchupkina, Tatiana

doi:10.15587/2519-4798.2019.185782

Cited by 1 publication

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References 6 publications

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“…Chronic alcohol abuse can lead to various neurological disorders, including chronic alcoholic encephalopathy (CAIE). According to several studies [11][12][13], CAIE is characterized by cognitive disorders, progressive impairment of intellectual functions, and in over 10.0 % of patients, it can lead to dementia. It is noteworthy that in a recent metaanalysis (2019), J. Rehm et al showed that there are possible links not only between chronic alcohol abuse (defined as the consumption of more than 60 g of pure alcohol per day for men and more than 40 g of pure alcohol per day for women) but also between irregular alcohol consumption and an increased risk of cognitive impairment or dementia [14].…”

Section: Introductionmentioning

confidence: 99%

Chronic Alcohol-Induced Encephalopathy: Predictors of Cognitive Impairment and Functional Disability

Duve

2023

Clin. and prev. med.

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Introduction: Predicting the risk of cognitive dysfunction and disability in everyday life among chronic alcohol-induced encephalopathy (CAIE) patients allows timely treatment to prevent dementia. The aim: to develop a mathematical model for predicting the risk of developing cognitive disorders and functional disability in patients with CAIE based on the analysis of polymorphic variants of the genes ACE, AT2R1, eNOS, PON1, IL-1β, IL-10, TNF-α, as well as cofactors (gender, age group, the disease duration, and presence/absence of somatic comorbidity). Materials and methods: We examined the 102 patients with CAIE who were undergoing inpatient treatment in the communal non-profit enterprise «Ternopil Regional Clinical Psychoneurological Hospital» during 2021-2022 and were included in the retrospective analysis. The molecular-genetic testing was performed for 26 patients of the general group. The molecular-genetic differentiation of the studied polymorphic variants of genes was carried out in the molecular-genetic laboratory of the state institution «Reference Centre for Molecular Diagnostics of the Ministry of Health of Ukraine», Kyiv. Cognitive functions were assessed using the Montreal Cognitive Test (MoCA); activities of daily living were assessed using the Barthel index. A logistic regression analysis was performed to determine the risk of cognitive impairment and functional disability developing in patients with CAIE. Results: Analyzing polymorphic variants of the ACE, AT2R1, eNOS, PON1, IL-1β, IL-10, TNF-α genes, as well as such cofactors as gender, age group, history and presence/absence of somatic comorbidity in the context of the development of cognitive disorders in patients with CAIE it has been established that the C108T polymorphism of the PON1 gene has the most significant prognostic value (in the presence of the T/T genotype, the probability of cognitive impairment is 39.84 %). At the same time, carriage of both the T allele and the C allele of the PON1 gene is associated with a significant decrease in the MoCA score. Regarding the development of functional disability in patients with CAIE, the C108T polymorphism of the PON1 gene also has the most significant prognostic value (in the presence of the T/T genotype, the probability of functional disability is 48.08 %, respectively, C/C – 30.96 % and CT – 39.22 %, however, no statistically significant differences in the Barthel index values were found in carriers of the above genotypes). Conclusions: It was established that the C108T polymorphism of the PON1 gene is significantly associated with the development of cognitive impairment and functional disability in patients with CAIE, which indicates the feasibility of further studies involving a larger sample of patients.

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Section: Introductionmentioning

confidence: 99%

Chronic Alcohol-Induced Encephalopathy: Predictors of Cognitive Impairment and Functional Disability

Duve

2023

Clin. and prev. med.

View full text Add to dashboard Cite

show abstract

Когнітивні Порушення У Осіб З Алкогольною Енцефалопатією Та Пароксизмальними Станами

Cited by 1 publication

References 6 publications

Chronic Alcohol-Induced Encephalopathy: Predictors of Cognitive Impairment and Functional Disability

Chronic Alcohol-Induced Encephalopathy: Predictors of Cognitive Impairment and Functional Disability

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