К ВОПРОСУ О ВЫЯВЛЕНИИ ТУБЕРКУЛЕЗА ОРГАНОВ ДЫХАНИЯ ПО РЕЗУЛЬТАТАМ СКРИНИНГА С ИСПОЛЬЗОВАНИЕМ КОЖНЫХ ИММУНОЛОГИЧЕСКИХ ТЕСТОВ У ПОДРОСТКОВ, "Вестник Центрального Научно-Исследовательского Института Туберкулеза"

Овсянкина, Елена Сергеевна; Панова, Людмила Владимировна; Хитева, А.Ю.; Полуэктова, Ф.А.

doi:10.7868/s2587667819060220

Cited by 2 publications

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“…Эффективность применения кожных иммунологических тестов у детей и подростков зависит от взаимодействия противотуберкулезной и педиатрической служб, которое предусматривает организационно-методическую работу учреждений противотуберкулезной службы по обучению медицинских работников ПМСП мероприятиям по профилактике и раннему выявлению туберкулеза на уровне этих учреждений на основе рационального использования директивных и методических документов по этому вопросу [11].…”

Section: основные положения по вопросам выявления и диагностики тубер...unclassified

Issues of interdisciplinary interaction during detection and diagnosis of tuberculosis in children and adolescents: a literature review and comments

Ovsyankina,

Panova,

Zakharova

2023

Medicinskij sovet

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Interdisciplinary interaction between phthisiatricians and pediatricians on the issues of detection and diagnosis of tuberculosis provides basis for the reduction of duration of the diagnostic process and the early identification of disease progression. The purpose of this review and comments is to systematize the knowledge of pediatricians about the detection and diagnosis of tuberculosis in children and adolescents in primary health care (PHC) facilities to improve the diagnostic process. We have performed an analysis and systematization of the current directive and methodological documents, articles on the detection and diagnosis of tuberculosis in PHC facitlities. The significance of skin immunological tests (Mantoux test using 5 tuberculin units (TU) of purified protein derivative (PPD)-L and a test with recombinant tuberculosis allergen (RTA)) during mass and selective screening to form groups at high risk for Tuberculosis and detect the disease is emphasized. The doctor’s actions based on the current guiding documents and laws are presented for cases when parents/legal representatives or the patient himself refuses from immunological skin tests. Positions that determine the need for interdisciplinary interaction for pediatricians on the issues of detection, diagnosis and differential diagnosis of tuberculosis are clearly articulated. The pathway to diagnosis begins with the formation of groups at high risk for tuberculosis in PHC facilities and with seeking medical help from a pediatrician in the presence of clinical signs similar to those of tuberculosis. Particular attention is paid to the detection of the disease when patients with clinical symptoms similar to those of tuberculosis seek medical help, and the missed opportunities for its early diagnosis are presented. Predictors allowing pediatricians to suspect tuberculosis and promptly refer a patient to a phthisiatrician to confirm / exclude the disease are provided.

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Section: основные положения по вопросам выявления и диагностики тубер...unclassified

Issues of interdisciplinary interaction during detection and diagnosis of tuberculosis in children and adolescents: a literature review and comments

Ovsyankina,

Panova,

Zakharova

2023

Medicinskij sovet

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“…Експерти ВООЗ прогнозують, що щорічний приріст хіміорезистентного ТБ становитиме 300 тис. нових випадків, у 80 % ви падків можлива стійкість до трьох із п'яти антимікобактеріальних препаратів (АМБП) І ря ду, найчастіше -до стрептоміцину, ізоніазиду і рифампіцину [10,11,13].…”

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“…В умовах збільшення частоти захворювання дорослого населення на резистентні форми ТБ легень найбільшої уваги потребують діти і підлітки з осередків множинної лікарсько-стійкої туберкульозної інфекції (ОМЛС-ТБІ) [1,2,7,8,11,15], зокрема слід вживати заходів, які запобігають розвитку небезпечної хвороби [3,12,13]. Основне місце серед них посідають специфічна профілактика та хіміопрофілактика ТБ [5,17].…”

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Application of BI-V for contact children and adolescents from focies of multidrug-resistant tuberculous infection: evaluation of effectiveness

Sakhelashvili¹,

Piskur²,

Sakhelashvili–Bil³

et al. 2023

ТБ

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Objective — to study the need of using the natural immunomodulator ВІ-V for contact children and adolescents from focies of multidrug-resistant tuberculous infection (MDR-TBI) for a non-specific immunoprevention of tuberculosis (TB). Materials and methods. A retrospective analysis of the medical records of 120 contacts (75 children and 45 adolescents) from focies of MDR-TBI and 102 adult with TB, who became the source of infection was carried out. Microbiological examination in adults included the detection of Mycobacterium tuberculosis (MBT) in sputum by smear microscopy, sowing of material on Levenstein—Jensen medium, typing of isolated MBT on BACTEC MGIT 960, determination of the drug susceptibility test (DST) of MBT to antimycobacterial drugs (AMBDs) of first- and second-line, as well as molecular genetic researched of sputum, in particular by the method of GeneXpert MTB/RIF and linear probe analysis. In the contact children from focies of MDR-TBI the determination of the population and subpopulation composition of blood lymphocytes was carried out among 25 children before and among 22 children after immunoprevention. Results and discussion. Most contact children and adolescents (61.7 %) from focies of MDR-TBI had concomitant diseases. The prophylactic administration of the BI-V immunomodulator reduced the frequency of acute respiratory viral infections and exacerbations of non-specific bronchopulmonary diseases by 2.0 times, the development of an active process from the latent tuberculous infection by 2.6 times, the frequency of transformation of latent tuberculosis infection into an active process by 2.6 times, improved appetite, memory, learning outcomes and increased physical activity. The latent tuberculous infection based on the Mantoux test results was found in 82.5 % (99) children. The quantiferon test confirmed the presence of a latent form of tuberculosis in 104 (86.7 %) contacts, the rest of the test results were negative. In children who received ВІ-V, latent tuberculous infection turned into an active process 2.8 times less often than in infected children who did not take this immunomodulator. The existing deviations into the regulatory system and the cellular response system disappeared after the autumn-spring course of ВІ-V. Conclusions. Immunomodulator ВІ-V is an effective preventive means for bronchopulmonary diseases, including MDR-TB among contact children and adolescents from focies of MDR-TBI.

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Cited by 2 publications

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Issues of interdisciplinary interaction during detection and diagnosis of tuberculosis in children and adolescents: a literature review and comments

Issues of interdisciplinary interaction during detection and diagnosis of tuberculosis in children and adolescents: a literature review and comments

Application of BI-V for contact children and adolescents from focies of multidrug-resistant tuberculous infection: evaluation of effectiveness

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