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Introduction. Sea buckthorn leaves are a promising object for the development of new medicinal herbal preparations due to an extensive list of biologically active substances (tannins, flavonoids, organic acids, etc.). However, despite the active study of biologically active substances of buckthorn buckthorn leaves, their use in medicine is limited to obtaining an antiviral drug "Hyporamine" containing a dry purified extract from the leaves of this plant.Aim. The aim of the work is to predict the pharmacological and toxic effects of decoction from buckthorn leaves in silico and to evaluate its anti-inflammatory activity in vivo in preclinical studies.Materials and methods. With the help of the PASS-online Internet resource, the prediction of promising pharmacological and possible toxic effects for the main biologically active substances of the phenolic complex of sea buckthorn leaves in silico was carried out. In preclinical studies in vivo (white outbred conventional male rats, 21 individuals, 210–240 g, 3 groups of 7 individuals each) on a model of formalin paw edema of rats (3.0 % aqueous formalin solution, 0.1 ml subplantarly), the anti-inflammatory activity of decoction of sea buckthorn leaves was evaluated. Animals of the experimental groups were administered: a comparison drug – an infusion of chamomile flowers or a decoction of sea buckthorn leaves at a dose of 10 ml/kg intragastrically daily for 7 days.Results and discussion. The analysis and systematization of data on the most likely pharmacological effects of the main biologically active substances of sea buckthorn leaves in silico using the PASS-online platform allow us to consider the most promising study of anti-inflammatory, hepatoprotective, cardioprotective, antibacterial, antifungal and antiviral activity, which opens up prospects for further preclinical and clinical studies in order to expand the list of indications for the use of extracts from the leaves of sea buckthorn. The prediction of the toxic effects of the main biologically active substances of sea buckthorn leaves showed that the smallest number of probable toxic effects is predicted for narcissin and quercetin, the largest for the substance strictinin I (including neurotoxicity, hematotoxicity, negative effects on the cardiovascular system, gastrointestinal toxicity, reproductive toxicity and carcinogenicity), which requires confirmations in preclinical toxicological studies. In preclinical studies in vivo on a model of rat paw edema, it was proved that a decoction of sea buckthorn leaves with a short-term oral course application of 7 days at a dose of 10 ml/kg (235 mg/kg based on the dry residue), it shows a sufficient anti-inflammatory effect, providing a significant, reliable decrease in the severity of rat paw edema, maximum 3 hours after phlogogen administration by 36.0 % compared with the control, which exceeds the effectiveness of the comparison drug (infusion of chamomile flowers).Conclusion. The main types of pharmacological activity (anti-inflammatory, hepatoprotective, cardioprotective, antibacterial, antifungal and antiviral) and toxic effects (neurotoxicity, hematotoxicity, negative effect on cardiovascular activity and gastrointestinal tract) have been established. Pronounced anti-inflammatory activity was reliably detected.
Introduction. Sea buckthorn leaves are a promising object for the development of new medicinal herbal preparations due to an extensive list of biologically active substances (tannins, flavonoids, organic acids, etc.). However, despite the active study of biologically active substances of buckthorn buckthorn leaves, their use in medicine is limited to obtaining an antiviral drug "Hyporamine" containing a dry purified extract from the leaves of this plant.Aim. The aim of the work is to predict the pharmacological and toxic effects of decoction from buckthorn leaves in silico and to evaluate its anti-inflammatory activity in vivo in preclinical studies.Materials and methods. With the help of the PASS-online Internet resource, the prediction of promising pharmacological and possible toxic effects for the main biologically active substances of the phenolic complex of sea buckthorn leaves in silico was carried out. In preclinical studies in vivo (white outbred conventional male rats, 21 individuals, 210–240 g, 3 groups of 7 individuals each) on a model of formalin paw edema of rats (3.0 % aqueous formalin solution, 0.1 ml subplantarly), the anti-inflammatory activity of decoction of sea buckthorn leaves was evaluated. Animals of the experimental groups were administered: a comparison drug – an infusion of chamomile flowers or a decoction of sea buckthorn leaves at a dose of 10 ml/kg intragastrically daily for 7 days.Results and discussion. The analysis and systematization of data on the most likely pharmacological effects of the main biologically active substances of sea buckthorn leaves in silico using the PASS-online platform allow us to consider the most promising study of anti-inflammatory, hepatoprotective, cardioprotective, antibacterial, antifungal and antiviral activity, which opens up prospects for further preclinical and clinical studies in order to expand the list of indications for the use of extracts from the leaves of sea buckthorn. The prediction of the toxic effects of the main biologically active substances of sea buckthorn leaves showed that the smallest number of probable toxic effects is predicted for narcissin and quercetin, the largest for the substance strictinin I (including neurotoxicity, hematotoxicity, negative effects on the cardiovascular system, gastrointestinal toxicity, reproductive toxicity and carcinogenicity), which requires confirmations in preclinical toxicological studies. In preclinical studies in vivo on a model of rat paw edema, it was proved that a decoction of sea buckthorn leaves with a short-term oral course application of 7 days at a dose of 10 ml/kg (235 mg/kg based on the dry residue), it shows a sufficient anti-inflammatory effect, providing a significant, reliable decrease in the severity of rat paw edema, maximum 3 hours after phlogogen administration by 36.0 % compared with the control, which exceeds the effectiveness of the comparison drug (infusion of chamomile flowers).Conclusion. The main types of pharmacological activity (anti-inflammatory, hepatoprotective, cardioprotective, antibacterial, antifungal and antiviral) and toxic effects (neurotoxicity, hematotoxicity, negative effect on cardiovascular activity and gastrointestinal tract) have been established. Pronounced anti-inflammatory activity was reliably detected.
Histochemical analysis of medicinal plants and raw materials is intended to be used to study the localization of various chemical substances and products of their metabolism in tissues. The article presents the results of histochemical analysis of leaves, flowers and stems of Dracocephalum ruyschiana L. and Dracocephalum nutans L. The genus Dracocephalum L. belongs to the family Lamiaceae Lindl. (Labiatae), whose plants are of interest as sources for medicinal preparations. These two species of Dracocephalum are related to Dracocephalum moldavica L., used in folk medicine for respiratory diseases, as an antipyretic agent, for asthenia, as a potency-increasing agent. Studies have shown that some species of Dracocephalum have antibacterial, antitussive, antidiarrheal, antioxidant, anti-cancer, anti-inflammatory, anti-diabetic and sedative properties. To determine the localization features of certain groups of secondary metabolites in the aerial part of Dracocephalum ruyschiana L. and Dracocephalum nutans L. growing in the territory of Central Kazakhstan at the microscopic level. Materials and methods. Cross-sections of stems, flowers, and D. ruyschiana and D. nutans were fixed in Strauss-Fleming solution, after which histochemical reactions were carried out to locate and identify essential oils, phenolic acids, flavonoids, sesquiterpene lactones, polysaccharides and alkaloids. The study of microscopic features, as well as histochemical tests were carried out according to the methods of the State Pharmacopoeia of the Republic of Kazakhstan using a light microscope Biomed-4. Results and Discussion. The localization of biologically active substances in the studied plant raw materials was determined by histochemical methods using light microscopy. The presence of phenolic acids, flavonoids and essential oil was established. The absence of sesquiterpene lactones, polysaccharides and alkaloids in the studied raw materials was established. Conclusion. The localization of secondary metabolites was studied for the first time by histochemical tests in the tissues of D. ruyschiana and D. nutans. The results of histochemical studies can be used to confirm the authenticity, identification and standardization of the aerial parts of D. ruyschiana and D. nutans.
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