Еffectiveness of immunocorrective therapy for frequently ill children

Abstract

Introduction. All acute respiratory infections are characterized by damage to the mucous membrane of the respiratory tract, a decrease in local immune defense and a weakening of nonspecific protective factors.Aim. To characterize the clinical effectiveness of the use of the immunocorrective drug in frequently ill children.Materials and methods. The article assessed the microbiological spectrum of the rhinopharyngeal landscape in 65 children: 33 children took an immunocorrective drug in addition to conventional therapy – the main group; 32 children received conventional therapy (the comparison group), and also investigated the possibility of regulating their polypathogenic microbiota using topical bacterial lysates.Results and discussion. The result of the therapy was a clinical improvement characterized by the relief of pharyngoscopic signs of chronic tonsillitis in children while taking topical bacterial lysates in form of lozenges. Analysis of the microbiota of the oropharyngeal mucosa in the studied patients of both groups before the start of therapy revealed the species diversity of opportunistic flora, among which Streptococcus pyogenes, Staphylococcus aureus, the family Enterobacteriaceae and Candida albicans were identified in all patients in diagnostic significant titers of 105–1010. After treatment in the main group, the ratio of the microbiota of the nasopharynx significantly changed, stimulation of the production of local immunity components was noted, which was confirmed by a decrease in the intensity of contamination of microbiota with polypathogenic functions to diagnostically insignificant titers. When comparing the species composition of the microbiota in the studied groups after treatment with topical bacterial lysates, a statistically significant positive effect was found without additional use of antibacterial drugs.Conclusions. It has been shown that the immunocorrective drug eliminates pharyngoscopic signs of rhinopharyngeal dysbiosis in children who are often and long-term ill.