ГИПЕРМЕТИЛИРОВАНИЕ ПРОМОТОРОВ ГЕНОВ В ЛЕЙКОЦИТАХ КРОВИ ЧЕЛОВЕКА В ОТДАЛЕННЫЙ ПЕРИОД ПОСЛЕ ПЕРЕНЕСЕННОГО РАДИАЦИОННОГО ВОЗДЕЙСТВИЯ, "Радиационная Биология. Радиоэкология"

Кузьмина, Н. С.; Lapteva, N. Sh.; Rusinova, Galina; Азизова, Т. В.; Вязовская, Н. С.; Рубанович, А. В.

doi:10.7868/s0869803117040014

Радиационная биология. Радиоэкология

2017

DOI: 10.7868/s0869803117040014

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ГИПЕРМЕТИЛИРОВАНИЕ ПРОМОТОРОВ ГЕНОВ В ЛЕЙКОЦИТАХ КРОВИ ЧЕЛОВЕКА В ОТДАЛЕННЫЙ ПЕРИОД ПОСЛЕ ПЕРЕНЕСЕННОГО РАДИАЦИОННОГО ВОЗДЕЙСТВИЯ, "Радиационная Биология. Радиоэкология"

Н. С. Кузьмина¹,

N. Sh. Lapteva²,

Galina Rusinova³

et al.

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“…Стабильность генома зависит и от генетических факторов, что подтверждается наличием ряда синдромов, в основе которых лежат мутации в генах репарации ДНК [6,7]. Однако, учитывая различную чувствительность клеток на фоне одинакового генотипа, можно говорить о наличии эпигенетических факторов, таких как метилирование, влияющих на частоту хромосомных нарушений [8,9].…”

unclassified

DNA double-strand breaks in immunoinflammatory rheumatic diseases

Avdeeva,

Aleksankin,

Verizhnikova

et al. 2023

Sovremennaâ revmatologiâ

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Objective: To study the frequency of spontaneous foci of DNA double-strand breaks (DSBs) in patients with immune-inflammatory rheumatic diseases (IIRD), their relationship to disease activity, levels of inflammatory markers, and levels of autoantibodies.Material and methods. The analysis included 40 patients with IIRD, including 19 patients with rheumatoid arthritis (RA, including 16 women, median disease duration 60 [20; 103] months, DAS28 was 5.05 [4.06; 5.9]) and 21 patients with systemic lupus erythematosus (SLE, 19 women, median disease duration 96.0 [40.0; 158.0] months, SLEDAI-2K 8.0 [4.0; 12.0]). The control group consisted of 17 healthy donors matched for sex and age.DNA DSBs were identified as discrete foci by immunofluorescence staining of lymphocyte cultures with antibodies against γH2AX and 53BP1 and subsequently analysed using the automated AKLIDES automated platform (Medipan).Results and discussion. There were no significant differences in the number of spontaneous DNA DSBs in patients with RA and healthy donors (p>0.05), a lower number of cells with the 53BP1 focus and a lower percentage of cells damaged in this focus were found in patients with SLE than in controls. There was a positive correlation between the number of γH2AXdamaged cells and CDAI(r=0.45, p=0.035), the number of cells with 53BP1 ruptures and the level of rheumatoid factor IgM (r=0.63, p=0.005) and ESR (r=0.53, p=0.02). In the group of SLE patients, a positive correlation was observed between the number of cells with breaks in the γH2AX focus and the level of antibodies against double-stranded DNA (anti-dsDNA; r=0.56, p=0.007), the average number of breaks in the cell in the γH2AX focus with the level of anti-dsDNA (r=0.57, p=0.004).Conclusion. The number of DNA DSBs may be an additional indicator of IIRD activity. In patients with SLE, DNA repair processes appear to be impaired, which is associated with the high activity of the disease.

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unclassified

DNA double-strand breaks in immunoinflammatory rheumatic diseases

Avdeeva,

Aleksankin,

Verizhnikova

et al. 2023

Sovremennaâ revmatologiâ

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Dose Dependence of Hypermethylation of Gene Promoters in Blood Leukocytes in Humans Occupationally Exposed to External γ-Radiation

Кузьмина

Lapteva

Rusinova

et al. 2019

Biol Bull Russ Acad Sci

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Radiation-Induced DNA Methylation Disorders: In Vitro and In Vivo Studies

Кузьмина

2021

Biol Bull Russ Acad Sci

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Cited by 5 publications

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DNA double-strand breaks in immunoinflammatory rheumatic diseases

DNA double-strand breaks in immunoinflammatory rheumatic diseases

Dose Dependence of Hypermethylation of Gene Promoters in Blood Leukocytes in Humans Occupationally Exposed to External γ-Radiation

Radiation-Induced DNA Methylation Disorders: In Vitro and In Vivo Studies

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