Возникновение Поражений Верхних Отделов Желудочно-Кишечного Тракта Во Время Терапии 5-Фторурацилом

Abstract

An important component of any cytotoxic drug therapy regimen prescribed for colon and rectosigmoid cancers is 5-fluorouracil. The drug is an antimetabolite of pyrimidine base -uracil, which is part of nucleotides on nitrogenous bases. 5-fluorouracil disrupts DNA synthesis and causes the formation of structurally imperfect RNA, inhibiting the division of tumor cells. In addition to effective antitumor activity, 5-fluorouracil has many side effects that affect the hematopoiesis system, liver, skin, nerve cells, cardiovascular and urinary systems. But most often the mucous membrane of the stomach and intestines suffers. The urgency of the problem causes the lack of generally accepted principles of prevention and treatment of lesions of the upper gastrointestinal tract.