Внескелетные Эффекты Витамина D

Povoroznyuk, V.V.; Резниченко, Н. А.; Maylyan, E. A.

doi:10.22141/2224-1507.1-2.13-14.2014.80057

Cited by 4 publications

(1 citation statement)

References 34 publications

(25 reference statements)

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“…It has been proven that VD functions are not limited to the control of calcium-phosphorus metabolism, but its other pleiotropic effects are being studied [1].…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Status on Lipid Metabolism of Children

Stroy

2018

Technology transfer: innovative solutions in medicine

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“…It has been proven that VD functions are not limited to the control of calcium-phosphorus metabolism, but its other pleiotropic effects are being studied [1].…”

Section: Introductionmentioning

confidence: 99%

Effect of Vitamin D Status on Lipid Metabolism of Children

Stroy

2018

Technology transfer: innovative solutions in medicine

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Prevalence of anticonvulsant-induced vitamin D deficiency

Dontseva

Pilipenko

Shnayder

et al. 2022

Èpilepsiâ paroksizmalʹnye sostoâ.

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Background. Epilepsy is a common disease in children and adults, requiring long-term or lifelong use of antiepileptic drugs (AEDs) in 60% of cases. Enzyme-inducing and enzyme-inhibiting AEDs may have a negative effect on vitamin D metabolism. However, at present, standard treatment protocols for patients with epilepsy include no nutrients and vitamin-mineral vitamin D containing complexes.Objective: to analyze studies on the prevalence of vitamin D deficiency induced by AEDs intake in patients with epilepsy.Material and methods. The search for full-text publications in Russian and English was carried out in еLibrary, PubMed/ MEDLINE, ClinicalKey, Google Scholar databases, covering the last five years. The analysis included 9 domestic and 54 foreign epidemiological studies assessing prevalence of AED-induced vitamin D deficiency and, consequently, altered bone mineralization and osteomalacia/osteoporosis.Results. Both in children and adults, the prevalence of AED-induced vitamin D deficiency reaches 40% and even higher. The region of residence of patients with epilepsy does not significantly affect this indicator. Impaired bone mineralization is associated with AED-induced vitamin D deficiency and requires the inclusion of vitamin D in the protocols of disease-modifying epilepsy therapy in children and adults.Conclusion. The results of the review showed high relevance of the discussed interdisciplinary problem and need to introduce laboratory screening of vitamin D deficiency among pediatric and adult patients with epilepsy.

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Identifying patients at risk of vitamin D deficiency in juvenile idiopathic arthritis

Mukvich

Omelchenko

Dudka

et al. 2022

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Background. The purpose was to determine the risk factors for reducing the provision of vitamin D (VD) in patients with juvenile idiopathic arthritis (JIA) and to develop a questionnaire for the rapid identification of children who require monitoring the concentration of 25OHD in the blood. Materials and methods. Clinical and laboratory examination of 78 children aged 2–17 years with JIA was performed. General clinical, biochemical, statistical methods and standardized criterion testing were used. Results. The most unfavorable risk factors for reducing VD provision in children with JIA have been identified, a questionnaire has been developed that can be used to identify people at high VD deficiency. Risk factors are evaluated in points. When questioning individuals with JIA, the total number of points obtained by each patient was determined. In children, who have received more than 264 points, VD insufficiency or deficiency is confirmed laboratorially. The electronic version of the questionnaire is created in the online service for remote testing with the ability to view results for each respondent separately and to identify patients at high risk of vitamin D deficiency. The questionnaire also allows separating groups of patients at risk of VD insufficiency for further monitoring of 25OHD concentrations in the blood serum, which is useful in clinical practice of children’s rheumatologist, pediatrician and family physician. Conclusions. In patients with JIA, it is necessary to determine the risk factors for reducing VD provision in the body to identify individuals who require the evaluation of its concentration in the blood with subsequent monitoring. A questionnaire has been developed that allows us to collect information on the risks of developing VD insufficiency, assess them and determine the basic cohort of patients for laboratory studies and deciding whether to prescribe vitamin D preparations to them.

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Внескелетные Эффекты Витамина D

Cited by 4 publications

References 34 publications

Effect of Vitamin D Status on Lipid Metabolism of Children

Effect of Vitamin D Status on Lipid Metabolism of Children

Prevalence of anticonvulsant-induced vitamin D deficiency

Identifying patients at risk of vitamin D deficiency in juvenile idiopathic arthritis

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