ВЛИЯНИЕ ФАКТОРА ДИФФЕРЕНЦИРОВКИ HLDF
            <i>
              in vitro
            </i>
            НА ИНВАЗИВНУЮ КАРЦИНОМУ МОЛОЧНОЙ ЖЕЛЕЗЫ НЕСПЕЦИФИЧЕСКОГО ТИПА

Аутеншлюс, А. И.; Жураковский, И. П.; Davletova, K I; Bogachuk, A. P.; Liakhovich, V V; Lipkin, V. M.

doi:10.31857/s2686738920060037

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Фактически выявленные дисбалансы являются манифестными формами сердечно-сосудистых, бронхолёгочных, мочеполовых и других заболеваний [26][27][28]. Совокупность выявленных иммунных дисбалансов как манифестных форм групп заболеваний у 16-88 лиц настораживает и требует дополнительного исследования в целях профилактики развития сердечно-сосудистой, мочеполовой и других патологий у обследуемых женщин на Севере.…”

Section: показателиunclassified

Cellular immunity in women aged 20–40 living in different climatic and geographic regions

Shchegoleva,

Shashkova,

Sergeeva

2024

Acta biomedica scientifica

View full text Add to dashboard Cite

The aim. To identify phenotypic features of adaptive cellular immune responses in young women living in different climatic and geographic regions.Materials and methods. We examined 63 apparently healthy women, including 25 residents of Sovpolye settlement, Arkhangelsk region (Arctic region) and 38 residents of Tskhinvali (Republic of South Ossetia) aged 20–40. The content of lymphocytes, their phenotypes CD4+, CD8+, CD3+, CD5+, CD16+, CD10+, CD71+, CD25+, HLA-DR+ and CD95+, CEA (carcinoembryonic antigen) glycoprotein, and interleukin (IL) 6 and IL-10 cytokines was studied. Lymphocytes phenotyping was performed by indirect immunoperoxidase reaction using monoclonal antibodies (MedBioSpektr, Moscow) on “dried drop” lymphocyte sample with peroxidase conjugate and chromogen solution staining for immersion microscopy analysis (Nicon 50i, Japan). The content of CEA glycoprotein and cytokines was determined using ELISA.Results. In women living in Arctic region, a deficiency of CD5+, CD3+, CD10+, CD95+, CD71+, CD25+, HLA-DR+ cells, CEA and IL-6 concentrations is associated with high concentrations of CD8+ and IL-10. In women living in Southern region, a slight deficiency of CD5+, CD8+ and CD95+ cells is associated with high concentrations of CEA, IL-6, IL-10 and CD10+, CD16+ and HLA-DR+ cells.Conclusion. In inhabitants of different climatic regions, the features of formation of adaptive immune reactions are determined by different quantitative and qualitative composition of lymphocytes and cytokines phenotypes. Reduction of reserve capabilities of immune homeostasis is detected 3 times more often in inhabitants of the Arctic region.

show abstract

Section: показателиunclassified