В-Хромосомы, "Успехи Современной Биологии"

Борисов, Ю.М.; Myshliavkina, T.A.

doi:10.7868/s0042132418040026

Cited by 3 publications

(1 citation statement)

References 52 publications

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“…В зависи мости от типа активации дифференцировка B-лим фоцитов происходит с образованием B-клеток памяти или плазмобластов/короткоживущих плазматических клеток. Последние дают начало долгоживущим плаз матическим клеткам и в отличие от пула B-клеток памяти способны длительно (более нескольких месяцев) персистировать и продуцировать антитела без предварительной антигенной стимуляции [9,10].…”

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Daratumumab in the treatment of pure red cell aplasia after pediatric allogeneic stem cell transplantation

Arakelyan

Blagov

Kovrygin

et al. 2023

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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Pure red cell aplasia (PRCA) is a rare complication of AB0-incompatible allogeneic hematopoietic stem cell transplantation, which manifests as a partial or complete absence of erythroid lineage in recipients with normal function of other hematopoietic lineages. There is a hypothesis, that lysis of erythroid precursors occurs because of antibody formation by population of residual B-lymphocytes and/or long-lived recipient’s plasma cells, which are capable for proliferation and active expression of the CD38 marker. That is why the invention of the IgG1 monoclonal antibody to CD38 presented as a new potentially effective targeted therapeutic option for patients with refractory PPCA. The article summarize clinical data on daratumumab for the therapy of PRCA in pediatric allogeneic hematopoietic stem cell transplantation recipients. The patients' parents gave their consent to the use of their children's data, including photographs, for research purposes and in publications.

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unclassified

Daratumumab in the treatment of pure red cell aplasia after pediatric allogeneic stem cell transplantation

Arakelyan

Blagov

Kovrygin

et al. 2023

Voprosy gematologii/onkologii i immunopatologii v pediatrii

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B Chromosome Variability in Plants and Animals under Extreme Environments

Borisov,

Sedel’nikova

2023

Russ J Genet

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B-Chromosome Variability in Plants and Animals under Extreme Environments

Borisov,

Sedel’nikova

2023

Genetika

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A review of data on B-chromosomes in populations of various systematic groups of plants and animals from their extreme habitats – the borders of the range and areas of the range exposed to unfavorable environmental factors is given. The analysis showed a rather similar picture of the distribution of B chromosomes in species from extreme habitats: there is a tendency to increase the number, occurrence and polymorphism of B chromosomes, which is accompanied by changes in the karyotype, genomic and chromosomal anomalies in their carriers. B chromosomes are often found in species with wide ranges. The possible adaptive role of B chromosomes in the vital activity of the organism and the evolution of genomes is discussed.

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В-Хромосомы, "Успехи Современной Биологии"

Cited by 3 publications

References 52 publications

Daratumumab in the treatment of pure red cell aplasia after pediatric allogeneic stem cell transplantation

Daratumumab in the treatment of pure red cell aplasia after pediatric allogeneic stem cell transplantation

B Chromosome Variability in Plants and Animals under Extreme Environments

B-Chromosome Variability in Plants and Animals under Extreme Environments

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