Анализ и выделение вторичных метаболитов гриба
            <i>
              Bipolaris sorokiniana
            </i>
            различными методами хроматографии и спектр их биологической активности

Берестецкий, А. О.; Dalinova, Anna; Dubovik, Vsevolod; Григорьева, Е. Н.; Kochura, Dmitry; Сендерский, И. В.; Смирнов, С. Н.; Степанычева, Е. А.; Turaeva, Saida

doi:10.31857/s0555109920050050

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…В последнее время интерес к ним существенно повышен (Zhang et al, 2019;Mao et al, 2020;Yuan et al, 2020). Наши собственные исследования показывают, что и фитопатогенные грибы (на примере патогенов злаков и сорных растений) могут образовывать инсектицидные метаболиты (Берестецкий и др., 2018б, 2020Dalinova et al, 2019Dalinova et al, , 2020. Относительно недавно началось изучение инсектицидных метаболитов морских видов микромицетов (Langenfeld et al, 2011;Chen et al, 2018;Bai et al, 2019).…”

Section: перспективные направления исследованийunclassified

Promising approaches to the search for fungal metabolites for management of arthropod pests

Берестецкий¹,

Lednev²,

Ху

2021

1727-1320

View full text Add to dashboard Cite

Biorational insecticides of natural origin, such as avermectins, spinosins, azadirachtin and afidopyropen, are increasingly used in agriculture. The present paper reviews modern ecological, genomic, and biotechnological approaches to the search for new compounds with insecticidal properties (entomotoxic, antifeedant, and hormonal) produced by fungi of various ecological groups (entomopathogens, soil saprotrophs, endophytes, phytopathogens, and mushrooms). The literature survey showed that insecticidal metabolites of entomopathogenic fungi had not been sufficiently studied, and the majority of well-characterized compounds had showed moderate insecticidal activity. The greatest number of substances with insecticidal properties was found to be produced by soil fungi, mainly from the genera Aspergillus and Penicillium. Metabolites with insecticidal and antifeedant properties were also found in endophytic and phytopathogenic fungi. Low sensitivity of insect pests of stored products (in particular, of grain) to mycotoxins was recorded. Mushrooms were found to be promising producers of antifeedant compounds as well as insecticidal proteins. It is possible to increase the number of substances with insecticidal properties detected in fungi not only by extension of the screening range but also by exploitation of diverse bioassay sytems and model insect species. Mining genomes for secondary metabolite gene clusters and secreted proteins with their subsequent activation by various methods allows for better understanding of the biosynthetic potential of the prospective strains. Efficacy of these studies can be increased with high-throughput techniques of fungal metabolites extraction and further analysis using chromatography and mass spectrometry. Insecticidal proteins detected in fungi can be used in the technologies for development of transgenic plant varieties resistant to pests, or hypervirulent bioinsecticides.

show abstract