АЛГОРИТМ Клинико-Иммунологической И ЛАБОРАТОРНОЙ ДИАГНОСТИКИ АТИПИЧНОЙ ХРОНИЧЕСКОЙ АКТИВНОЙ Эпштейн-Барр ГЕРПЕСВИРУСНОЙ ИНФЕКЦИИ, "Российский Иммунологический Журнал"

Нестерова, И. В.; Khalturina, E. O.

doi:10.7868/s1028722118020089

Cited by 3 publications

(6 citation statements)

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“…Единичные случаи, когда IgG к ВПГ2 и ВГЧ6 не идентифицируются как на фоне вы явления антигена и репродукции вирусов в культуре клеток, так и спустя полгода, с од ной стороны, можно объяснить наличием иммуносупрессии, характерной для герпес вирусов и описанной другими авторами [23,24]. С другой -биологическими особенно стями герпесвирусов, имеющими сущест венное антигенное сходство.…”

Section: исследованияunclassified

“…Этот факт позволяет предположить, что для снижения серопрева лентности ВЭБ требуется существенно больше времени, по сравнению с другими исследуемыми герпесвирусами. Вероятно, для значимого снижения концентрации спе цифических IgG у ряда пациентов недоста точно времени между двумя эпизодами реак тивации данной инфекции [23,39].…”

Section: исследованияunclassified

“…Оценка показателей гуморального им мунитета не выявила значимого влияния ре активации герпесвирусных инфекций на уровни общих иммуноглобулинов A, M, G, E и ЦИК. Это вполне логично, поскольку при реактивации латентной инфекции, проте кающей без выраженных клинических прояв лений и значимых изменений показателей общего и биохимического анализов крови, крайне редко специфические иммуноглобу лины М достигают высоких значений, а рост концентрации специфических IgG незначи телен или совсем отсутствует [23,39]. Ранее было показано, что острая герпесвирусная инфекция у детей также не сопряжена с по вышением уровней общих иммуноглобули нов A, M, G, E и ЦИК [40,41].…”

Section: исследованияunclassified

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Features of change of immune status indicators in individuals with active and latent forms of herpes-virus infections

Solomay

Соломай²,

Семененко

et al. 2021

Perm Med J

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Objective. The aim of the study is to investigate the peculiarities of changes in the immune status of individuals with active and latent forms of herpesvirus infections. Herpesvirus infections are an urgent problem of modern health care. Materials and methods. The prospective longitudinal cohort study included 92 permanent blood donors who were examined twice at 6-month intervals for the presence of specific IgM and IgG antibodies and antigens of herpes simplex viruses 1, 2, Epstein-Barr, cytomegalovirus, human herpesvirus type 6, as well as humoral immunity indicators. Results. In the period from October to April, 68.5 % of blood and its components donors were found to have markers of active herpesvirus infection caused by HSV 1, 2, EBV, CMV, and HHV6. The combination of the detected markers in the absence of clinical manifestations and changes in General and biochemical blood tests indicated asymptomatic reactivation of latent infection. The frequency of reactivations in the autumn and spring months is the same. The absence of IgG production after asymptomatic reactivation of HSV-2 and HHV-6 infections and an increase in IgG concentrations to HSV-1, EBV, and CMV were revealed. EBV infection is the most common among the studied nosologies (98.91 %) and is characterized by statistically significantly higher levels of specific IgG. The effect of asymptomatic reactivation of herpesvirus infections on the levels of total IDA, IgM, IgG, IDE, and CEC was not established. Conclusions. Asymptomatic reactivation of herpesvirus infections does not significantly affect the changes in immune status indicators, and the absence of clinical manifestations, and significant changes in General and biochemical blood tests cause epidemiological risks associated with difficulties in identifying the sources of infection.

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Section: исследованияunclassified

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Features of change of immune status indicators in individuals with active and latent forms of herpes-virus infections

Solomay

Соломай²,

Семененко

et al. 2021

Perm Med J

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“…Офтальмологические проявления при данной инфекции носят разнообразный характер, затрагивая различные структуры глаза, и возникают на разных сроках: как в острый период течения заболевания и на этапе реконвалесценции, так и в постковидный период [7]. В настоящее время в ряде отечественных и зарубежных исследований чаще всего описываются изменения переднего отрезка глаза: конъюнктивит, эписклерит, кератит, кератоконъюнктивит, эрозия роговицы, иридоциклит [7][8][9][10][11]. Так, острый конъюнктивит может быть единственным проявлением COVID-19, в связи с этим офтальмологам необходимо быть настороженными при обследовании пациентов, строго соблюдать санитарные правила и пользоваться средствами индивидуальной защиты в полном объеме [7,9].…”

Section: Introductionunclassified

Acute Vascular Pathology of the Eye as a Complication of the Past COVID-19 Infection. Clinical Observations

2023

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Ophthalmological manifestations in COVID-19 infection are diverse, manifesting themselves in all anatomical structures of organ of vision, they occur both in the acute period of the disease and in the post-COVID period. Currently, the literature describes changes in the anterior segment of the eye more often, and also there are publications describing pathological changes in the posterior segment, and acute vascular pathology of the retina after COVID-19 infection in particular. It has been established that the comorbid background of the patient is of great importance in the development and the course of the disease. These findings are also confirmed by our two clinical observations of acute ocular vascular pathology after COVID-19. In the first case, retinovasculitis of the right eye complicated by thrombosis of the inferior temporal branch of the central retinal vein was described. The development of vascular pathology of the eye in this case was observed 1.5 months after the onset of the first symptoms of COVID-19 infection. The patient promptly turned to an ophthalmologist and was hospitalized to an eye hospital, where she received anti-inflammatory, hemostatic, anticoagulant, antibacterial, angioprotective, antioxidant therapy. As a result of treatment — the improvement of condition, restoration of visual functions. In the second presented case, we observed the development of an acute ischemic circulatory disorder of the retina of the left eye (thrombosis of the central retinal vein) 2.5 months after the onset of the disease with a new coronavirus infection. The treatment in an ophthalmological hospital included: steroid and non-steroidal anti-inflammatory drugs, antibiotics, mydriatics, haemostatics, angioprotectors, antioxidants, anticoagulants, vitamins. On discharge from the hospital, there was a slight improvement, but after 2 months, the condition of the left eye worsened again. The pathology of the organ of vision proceeded with the development of complication — secondary neovascular glaucoma of a refractory nature with an outcome to subatrophy of the eyeball. It was facilitated by the comorbid background of the patient: hypertension, type 2 diabetes mellitus, dyslipidemia.Based on the results of the analysis of clinical observations, the specific features of ophthalmological changes, their severity and dynamics on the background of comorbidity and the received therapy were established. The relationship between COVID-19 infection and complications of the organ of vision has been shown.

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“…Использование в лечении ЧДБ детей препарата ВИФЕРОН ® как местно (в виде геля или мази), так и системно (ректальные суппозитории) в высоких или средних дозах 300 000-500 000 МЕ в начале заболевания, с последующим их снижением в 1,5-2 раза каждые 2-3 недели, позволило получить положительную динамику клинической картины: частота ОРВИ снижалась с 10-18 до 2-3 в году, сокращалось число бактериальных осложнений в 4-6 раз, ускорялось достижение клинической ремиссии в 6-8 раз, а длительность ремиссии увеличилась в 8-10 раз -с 7-10 дней до 100-150 дней. Положительные клинические эффекты, как правило, сопровождались соответствующими изменениями показателей иммунной системы [6,11].…”

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Еxternal forms of recombinant interferon alfa-2b - ointment and gel in the treatment of acute respiratory viral infections and influenza in children

et al. 2020

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The review article presents the results of numerous studies on the effectiveness and safety of the newly developed forms of the human recombinant interferon alpha- 2b drug, ointment and gel, intended for the treatment and prevention of acute respiratory viral infections and influenza in children. Еxternal forms of the drug retain immunomodulatory, antiviral and antiproliferative effects. The dosage form of the preparation of interferon alpha-2b VIFERON® in the form of a gel or ointment allows to achieve a prolonged action due to good absorption, especially the gel, which increases its effectiveness, and also has a moisturizing effect and rarely causes allergies. All of the above properties justify the inclusion of the drug interferon alpha-2b VIFERON® in the form of a gel or ointment in the complex treatment of influenza and acute respiratory viral infections in children.

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Cited by 3 publications

References 0 publications

Features of change of immune status indicators in individuals with active and latent forms of herpes-virus infections

Features of change of immune status indicators in individuals with active and latent forms of herpes-virus infections

Acute Vascular Pathology of the Eye as a Complication of the Past COVID-19 Infection. Clinical Observations

Еxternal forms of recombinant interferon alfa-2b - ointment and gel in the treatment of acute respiratory viral infections and influenza in children

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