Актуальность Удаления Невуса Ядассона У Лиц Молодого Возраста

Гайдина, Т. А.; Дворников, А. С.; Скрипкина, П. А.; Арутюнян, Г. Б.; Реднор, Москва Ооо Компания

doi:10.24075/vrgmu.2018.033

Вестник РГМУ

2018

DOI: 10.24075/vrgmu.2018.033

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Актуальность Удаления Невуса Ядассона У Лиц Молодого Возраста

Т. А. Гайдина¹,

А. С. Дворников²,

П. А. Скрипкина³

et al.

Abstract: Одним из доброкачественных образований кожи является себорейный невус Ядассона (NSJ) -гамартома, локализующаяся преимущественно на коже лица или волосистой части головы и одинаково часто встречающаяся у мужчин и женщин. Плюрипотентные первичные эпителиальные клетки, входящие в структуру NSJ, являются благоприятной средой для развития на его фоне как доброкачественных, так и злокачественных опухолей. Для исключения неопластической трансформации целесообразно удалять NSJ сразу после полового созревания. При нево… Show more

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Differential diagnosis of Brooke–Spiegler syndrome in a young woman with multiple trichoepitheliomas

Gaydina¹,

Дворников²,

Скрипкина³

et al. 2023

Russian Journal of Skin and Venereal Diseases

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BrookeSpiegler syndrome (Brooke-Spiegler syndrome; OMIM #605041) is a rare, autosomal dominant inherited monogenic disease caused by mutations in gene CYLD with its different penetrance. It is clinically manifested by the development of multiple neoplasms of skin appendages such as spiradenoma, cylindroma, spiradenocylindroma and trichoepithelioma. Several phenotypic variants with mutations in gene CYLD have been described in the scientific literature. They are classic BrookeSpiegler syndrome; multiple familial trichoepithelioma syndrome (multiple trichoepitheliomas without cylindromas, spiradenomas, etc.); familial cylindromatosis (multiple cylindromas on the scalp i.e., "turban tumor"); syndrome of multiple spiradenomas or spiradenocylindromas without other neoplasms of the skin appendages. For four diseases associated with CYLD mutations, the prevalence is 1/1 000 000. The scientific literature describes more than 200 cases of BrookeSpiegler syndrome, which is more common in women. Phenotypic manifestations of the CYLD mutation are variable, so there is no reliable statistics on the frequency of occurrence of clinical variants of BrookeSpiegler syndrome. The variety of neoplasms of the skin appendages, the commonality of their histogenesis, the similarity of clinical and histological patterns significantly complicate the diagnosis. Verification of the diagnosis of BrookeSpiegler syndrome is based on histological examination and sequencing of the CYLD gene.

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Differential diagnosis of Brooke–Spiegler syndrome in a young woman with multiple trichoepitheliomas

Gaydina¹,

Дворников²,

Скрипкина³

et al. 2023

Russian Journal of Skin and Venereal Diseases

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Jadassohn's nevus in a newborn: surgical treatment or conservative tactics

Karyakina,

Rekhviashvili,

Bazina

et al. 2024

Russian Journal of Pediatric Surgery

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BACKGROUND: Jadassohn's nevus (seborrheic nevus, nevus of the sebaceous glands) is a hamartoma which is mainly localized on the scalp and face skin. At birth, it looks like a barely noticeable light yellow plaque which significantly increases at the puberty period under androgenic stimulation. The histological picture of Jadasson's nevus is characterized by changes in the epidermis in the form of acanthosis, papillomatosis, hyperkeratosis, and a large number of hyperplastic sebaceous glands. Pluripotent epithelial cells, which are part of the hamartoma, may provoke the growth of secondary benign and malignant tumors. This nevus may be manifested by Schimmelpenning–Feuerstein–Mims syndrome which can damage the nervous system and eyes. Currently, there are no uniform recommendations for the management of patients with Jadassohn's nevus. CLINICAL CASE DESCRIPTION: In this article, we present our own experience of treating two children discussed pathology. The first boy had a radical surgery at the age of 16 days of life because of large dimensions of the nevus and a significant cosmetic defect. Removal of the formation at the neonatal period has prevented the development of rough postoperative scars and promoted good cosmetic outcome due to high elastic and regenerative properties of baby's skin. In the second child, Jadasson's nevus looked like a barely noticeable light yellow plaque; therefore, conservative tactics was chosen for this patient. Both children were consulted by a neurologist and an ophthalmologist who found no pathology in the nervous system and in the vision organs. CONCLUSION: The described two clinical examples demonstrate the need for individual and multidisciplinary approaches in the management of patients with Jadasson's nevus. Active surgical tactics should be applied because of a significant cosmetic defect rather than for the prevention of malignant transformation which is met in less than 1% of cases.

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Treatment of the nevus sebaceous of Jadasson by a copper vapor laser

Ponomarev

Владимирович²,

Topchy

et al. 2020

Vestnik dermatologii i venerologii

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Introduction. Nevus sebaceous of Jadassohn (synonym: nevus of the sebaceous glands) (NSG) presents the congenital malformation of the skin with possible transformation into benign or malignant tumors during the adolescence or adulthood. Commonly appeared on the scalp or neck NSG is frequently concern with cosmetic problems making patients look for opportunities for its removal. Surgical removal of the NSG is related to an elevated risk of scarring. Using ablative lasers has proven to be effective in the removal of small NSG. However, the removal of medium and large NSG with ablative lasers was reported to be linked with a high risk of scarring and recurrence. The removal of the medium-sized NSG with a copper vapor laser (CVL) is described here for the first time. Case report and procedure. Laser removal of NSG (linear sized of 27 mm) was performed in a 25-year-old female patient with Fitzpatrick skin type II during eight CVL treatments. Laser settings were selected as follows: the average power of 1 W at the power ratio of 3:2 radiation at a wavelength of 511 and 578 nm. Pulse duration 20 nanoseconds, reprate 16.6 kHz, exposure duration 200 ms, and the light spot's diameter on the skin 1 mm. Results. After 8 procedures, the skin in the area of the removed NSG acquired a natural color and appearance. During 24 months of follow-up, there was no hyperpigmentation or signs of scars in the irradiated area. No relapses were observed for 24 months after the CVL removal of NSG. Conclusion. The application of non-ablative CVL removal of NSG ensured a desired cosmetic result without side effects.

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Актуальность Удаления Невуса Ядассона У Лиц Молодого Возраста

Cited by 3 publications

References 0 publications

Differential diagnosis of Brooke–Spiegler syndrome in a young woman with multiple trichoepitheliomas

Differential diagnosis of Brooke–Spiegler syndrome in a young woman with multiple trichoepitheliomas

Jadassohn's nevus in a newborn: surgical treatment or conservative tactics

Treatment of the nevus sebaceous of Jadasson by a copper vapor laser

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