Агрегатометрия В Диагностике Тромбоцитопатий У Детей

Ярец, Ю. И.; Ромашевская, И. П.; Ходулева, С. А.; Малишевская, И.А.; Демиденко, А. Н.; Мицура, Е. Ф.

doi:10.34883/pi.2021.7.4.013

Гематология. Трансфузиология. Восточная Европа 2021

DOI: 10.34883/pi.2021.7.4.013

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Агрегатометрия В Диагностике Тромбоцитопатий У Детей

Ю. И. Ярец¹,

И. П. Ромашевская²,

С. А. Ходулева³

et al.

Abstract: Диагностика тромбоцитопатий (ТП) имеет свои сложности. Чаще всего ТП проявляются носовыми кровотечениями, меноррагиями и другими кровотечениями слизистых. Поэтому при наличии в анамнезе кровотечений по микроциркуляторному типу необходимо проводить подробный сбор анамнеза и соответствующие диагностические исследования. Оценку функциональной активности тромбоцитов в большинстве случаев осуществляют методом агрегометрии. Современной лабораторной технологией является импедансная агрегатометрия, которая позволяет п… Show more

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2024

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The results of the cross-sectional study of platelet aggregative function in children with hemorrhagic syndrome

Gordeeva,

Dobrotok,

Volkova

et al. 2024

Pediatr. farmakol.

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Background. Early diagnosis of thrombocytopathies in children is a relevant objective of pediatrics. Diagnostics helps prevent the development of bleeding, chronic posthemorrhagic anemia, reduces the risk of thrombosis.The aim of the study is an assessment of the incidence of platelet aggregation disorders in children with manifestations of hemorrhagic syndrome against the background of chronic pathology.Methods. The study was conducted on the basis of the Research Institute of Pediatrics and Children’s Health, Scientific Center No. 2, Petrovsky National Research Centre of Surgery in the period from January — until December 2022. 62 children were included in the study, of which 50 children were selected (21 boys and 29 girls) aged 2 years 3 months to 17 years 11 months. The median age was 9.4 (7.2; 13.4). Aggregometry was performed using an impedance semiautomatic aggregometer in whole blood.Results. Depending on the diagnosis, the children were divided into the following groups: cardiovascular diseases (CVD), lysosomal storage disorders (LSD), monogenic hereditary diseases (MHD), children with dysplastic syndrome (DS), children with pathology of the nervous system (NS). Hypoaggregation with thrombin-activating peptide (TRAP test) was detected in 28% of cases (n = 14), more often in children from the group with MHD — 10% (n = 5) and with the presenceof DS — 10% (n = 5). Hypoaggregation with adenosine diphosphate (ADP test) was detected in 20% of cases (n = 10), with arachidonic acid (ASPI test) was detected in 14% (n = 7). Hyperaggregation with the TRAP test was detected in 12% (n = 6), with the ADP test detected in 8% of cases (n = 4). Hyperaggregation with ASPI test was detected in 18% of cases (n = 9).Conclusion. The analyzed results of laboratory tests of platelet aggregation function, hypoaggregation with inducers was observed in more than half of the children, hyperaggregation was observed was present in almost half of the patients.

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The results of the cross-sectional study of platelet aggregative function in children with hemorrhagic syndrome

Gordeeva,

Dobrotok,

Volkova

et al. 2024

Pediatr. farmakol.

View full text Add to dashboard Cite

show abstract

Study of Platelet Aggregation Function in Children Undergoing COVID-19. Initial Results

Gordeeva,

Namazova-Baranova,

Dobrotok

et al. 2024

Annals RAMS

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Background. There is evidence that platelet dysfunction in new-type coronavirus infection can lead to both thrombotic and hemorrhagic events: hypercoagulation syndrome leading to thrombosis is one of the most threatening complications of COVID-19; equally important is the hemorrhagic syndrome that can be observed after this disease. The study of platelet aggregation function in children with new-onset coronavirus infection is highly relevant: the results of aggregometry in pediatric practice may help to predict the development of complications from vascular and platelet hemostasis. Aims — to evaluate the direction of changes in platelet haemostasis in children undergoing COVID-19. Methods. In the first phase of the work, we clarified the normal values of platelet aggregation in children with different inducers in whole blood by impedance testing (based on examination data from 105 conditionally healthy children who had not had COVID-19). At the second (main) phase of the study we conducted a single-stage prospective study including 250 pediatric patients residing in the Russian Federation: 143 children suffered mild COVID-19, while the comparison group consisted of 107 patients who had not been ill with a new-type coronavirus infection. All children (those who had COVID-19 and those who had no disease) underwent a comprehensive examination, which included: physical examination, aggregometry and laboratory tests (to rule out acute inflammatory process and hemogram abnormalities potentially affecting platelet aggregation rates). Results. Almost half of the patients after COVID-19 had platelet aggregation abnormalities. At the same time, in every third child there were combined multidirectional disorders in the form of hypo- and hyperaggregation with different inducers, in contrast to the group of children who did not have COVID19 (p 0.05). In the COVID19 group aggregation abnormalities with arachidonic acid were most frequently detected: almost every second patient had hyperaggregation and every fourth patient had hypoaggregation, which was statistically significantly different from the non-disease group (p 0.05). Analysis of the results depending on the time interval after the disease (1–3 months, 3–6, 6–12 months, more than 12 months) showed platelet hyperaggregation with all inducers at 1–3 months, and there was a tendency to reduce aggregation with thrombin and ADP, but hyperaggregation with arachidonic acid persisted for one year after the disease. At an interval of more than one year after COVID-19 every second patient showed a decrease in platelet function (hypoaggregation with all inducers). No statistically significant differences by gender were observed depending on the time interval after the infection. Conclusions. The results of the study demonstrate the vectors of impaired vascular and platelet hemostasis in children with mild COVID-19: The time intervals of platelet dysfunction after the disease have been determined. The results of the study may help to develop a surveillance strategy for children who have had a new type of coronavirus infection to prevent the development of complications from vascular and platelet hemostasis.

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Агрегатометрия В Диагностике Тромбоцитопатий У Детей

Cited by 2 publications

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The results of the cross-sectional study of platelet aggregative function in children with hemorrhagic syndrome

The results of the cross-sectional study of platelet aggregative function in children with hemorrhagic syndrome

Study of Platelet Aggregation Function in Children Undergoing COVID-19. Initial Results

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