Аrterial stiffness and cardiovascular autonomic neuropathy relationship in children and adolescents with type 1 diabetes mellitus

Abstract

Повышение ригидности артериальной стенки у детей и подростков с сахарным диабетом 1 типа и автономной дисфункцией Лаптев Д.Н. ФГБУ Эндокринологический научный центр, Москва(директор -академик РАН И.И. Дедов) 15,7 [14,3; 17,3] лет, длительность СД 6 [2,6; 10] Цель. Определение связи жесткости магистральных артерий с кардиоваскулярной формой автономной нейропатии (КАН) у детей и подростков с сахарным диабетом 1 типа (СД1

Association of arterial stiffness and neuropathy in diabetes: a systematic review and meta-analysis

“…In total, 60 studies were included in the systematic review,26–85 with 43 of those studies including at least one arterial stiffness measurement suitable for meta-analysis 29–31 33–35 37–39 41 42 46 47 52 53 55 57 59–77 79–85. Although various studies adjusted for age, sex, diabetes duration, or SBP in data analysis, the values used in the meta-analyses were not adjusted for, other than those studies that only included participants of one sex 65 75.…”

“…For the purposes of investigating arterial stiffness and neuropathy, we classified 53 of the studies as cross-sectional,26 28–31 33–36 38–62 64–67 69 71 73–85 5 as case-control37 63 68 70 72 and 2 as cohort 27 32. For cross-sectional studies, all participants had diabetes, except Allison et al 26 and Kuo et al ,46 who included participants regardless of diabetes status, as well as Cho et al ,35 who alongside participants with diabetes, also separately analyzed those with no history of disease known to cause PN.…”

“…Of the 59 studies specifying inclusion of participants with diabetes, 38 were carried out in people with type 2 diabetes,27 29 30 32–34 36 39 41–43 45 48 49 51 54–56 59 60 62 64–67 70–72 75–77 79–85 11 in people with type 1 diabetes37 40 44 47 50 53 58 63 69 74 78 and 4 in people with either type 1 or type 2 diabetes31 38 57 73 with Fleischer et al 38 and Moţăţăianu et al 57 reporting separate results for type 1 and type 2 diabetes. Six studies did not specify diabetes type 26 35 46 52 61 68.…”

“…Six studies did not specify diabetes type 26 35 46 52 61 68. Of the 49 studies that reported mean diabetes duration, 26 had a mean diabetes duration of at least 10 years29 31 33 34 36–38 40 41 44 48 50 53 54 56 58 59 62 63 67–69 74 76 78 82 and 22 had a mean diabetes duration of less than 10 years 27 30 32 39 42 43 47 49 55 60 64 65 70 71 73 75 79–81 83–85. Moţăţăianu et al 57 reported mean diabetes duration of 16 years for type 1 diabetes and mean diabetes duration of 7 years for type 2 diabetes.…”

Factors associated with abnormal cardio-ankle vascular index in patients with type 2 diabetes and prediabetes

“…Закономерно, что для адекватной профилактики кардиоваскулярных осложнений необходимо выявлять их ранние предвест-ники. Одним из таких маркеров является повышенная жесткость артерий [2,3]. Традиционно использовавшийся для оценки данного параметра показатель -скорость распространения пульсовой волны -имеет ряд ограни-чений (отсутствие стандартизации, зависимость от опе-ратора, от уровня артериального давления).…”