ω-conotoxin sensitive voltage-operated calcium channels: Pharmacological and immunological properties

Nicotinic Receptors and Calcium Channels in Small Cell Lung Carcinoma: Functional Role, Modulation, and Autoimmunitya

“…The first papers on SCLC VOCCs concluded that only L‐type VOCCs were present in these cells. 15,16,18 By using more detailed approaches, both we 17,19,22 and others 21,23 have then shown that SCLC cells express multiple VOCC subtypes.…”

“…Some basic electrical properties of SCLC cells have been reported by McCann and collaborators. 13,14 KC1‐induced 45 Ca 2+ influx was then shown by Roberts et al 15 and de Aizpurua et al , 16 while KC1‐induced increase in [Ca 2+ ] i was characterized by Sher et al 17 Ca 2+ (or Ba 2+ ) currents have been studied more recently with the patchclamp technique by Pancrazio et al , 18 Codignola et al , 19 Viglione et al , 20 Barry et al , 21 Sher et al , 22 and Meriney et al 23…”

“…The presence of L‐type VOCCs in SCLC cells was demonstrated by showing DHP's effects on KC1‐induced 45 Ca 2+ influx, 15,16 increase in [Ca 2+ ] i 17 and Ca 2+ currents, 18,19 [ 3 H]‐DHP binding, 15 and the presence of the α 1D mRNA. 19…”

“…SCLC cells express also N‐type VOCCs, as revealed by [ 125 I]‐ω‐Ctx GVIA binding assays, 17ω‐Ctx GVIA effects on KC1‐induced 45 Ca 2+ influx, 16 increase in [Ca 2+ ] i 17 and Ca 2+ currents, 19 and finally the presence of the α 1B mRNA. 19…”