ω-Conotoxin increases sleep time following ethanol injection

Brown, Laurie M.; Sims, Joanne S.; Randall, Patrick K.; Wilcox, Richard E.; Leslie, Steven W.

doi:10.1016/0741-8329(93)90097-8

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…Despite this, a previous study investigating the role of N-type calcium channels in hypnotic responses to ethanol showed that intraventricular administration of ω -conotoxin GVIA prolonged the ethanol-induced loss of the righting reflex when given 4 h before ethanol in food-deprived rats (Brown et al, 1993). The discrepancy between the data obtained in that study and our data presented here may be related to the fact that ω -conotoxin GVIA exhibits some off-target activities, including inhibition of L-type calcium channels (McCleskey et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

A Blocker of N- and T-type Voltage-Gated Calcium Channels Attenuates Ethanol-Induced Intoxication, Place Preference, Self-Administration, and Reinstatement

et al. 2008

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There is a clear need for new therapeutics to treat alcoholism. Here, we test our hypothesis that selective inhibitors of neuronal calcium channels will reduce ethanol consumption and intoxication, based on our previous studies using knock-out mice and cell culture systems. We demonstrate that pretreatment with the novel mixed N-type and T-type calcium channel antagonist 1-(6,6-bis(4-fluorophenyl)hexyl)-4-(3,4,5-trimethoxybenzyl)piperazine (NP078585) reduced ethanol intoxication. NP078585 also attenuated the reinforcing and rewarding properties of ethanol, measured by operant self-administration and the expression of an ethanol conditioned place preference, and abolished stress-induced reinstatement of ethanol seeking. NP078585 did not affect alcohol responses in mice lacking N-type calcium channels. These results suggest that selective calcium channel inhibitors may be useful in reducing acute ethanol intoxication and alcohol consumption by human alcoholics.

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Section: Discussionmentioning

confidence: 99%

A Blocker of N- and T-type Voltage-Gated Calcium Channels Attenuates Ethanol-Induced Intoxication, Place Preference, Self-Administration, and Reinstatement

et al. 2008

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“…46) Cf. Leslie Brown (1993) and Jacob Grimm (1897). 47) Leslie Brown (1993), 580. community of interest.…”

Section: Th E Lexicographical Expanse Of the Conceptsmentioning

confidence: 99%

“…Leslie Brown (1993) and Jacob Grimm (1897). 47) Leslie Brown (1993), 580. community of interest. It has retained the eighteenth century meaning of "a body of people organised into a political, municipal or social unity; a state or commonwealth," suggesting sub-entities of a larger society, as in the breakdown of a nation into separate communities.…”

Section: Th E Lexicographical Expanse Of the Conceptsmentioning

confidence: 99%

“…49 In her magisterial work on communitarian politics, Elisabeth Frazer presents one of the problems of defi ning community: apologising for her Oxonian preoccupation with language, she notes that it is unclear whether "community" should entail either: a bounded geographical area; a dense network of non-contractual relations including those of kinship, friendship and cultural membership; a network, dense or otherwise, of multiplex relations a particular quality of identifi cation on the part of members with place, or culture, or way of life, or tradition -usually involving emotional attachment, loyalty, solidarity or unity, and/or a sense that the community makes the person what they are; 48) 1884, Standard, 29 Feb. 2/4., Amy Levy in Rueben Sachs i, 2, quoted Leslie Brown (1993), 580-582. 49) Leslie Brown (1993), 582. shared symbols, meanings, values, language, norms; shared interests such as occupational interests (as in a "fi shing community") or political and cultural interests (as in "the gay community").…”

Section: Th E Lexicographical Expanse Of the Conceptsmentioning

confidence: 99%

“…After the founding of the Universal Communitarian Association and of the London Communist Propaganda Society by Goodwyn Barmby in 1841, Miall interestingly accused "communitarians, or societarians of modern days" of being "intent on fashioning a new moral world by getting rid of all individuality of feeling." 62 In 1926, that is, before the advent of the Th ird Reich, Aldous Huxley presciently blazoned the triad "Community, Identity, Stability" upon the shield of the World State in Brave New World, presenting "community" as the sum total of "identity" in the service of "stability," as a means generated through collective identifi cation aimed primarily at stabilising power. 63…”

Section: Th E Concepts As Catchwordsmentioning

confidence: 99%

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Gemeinschaft und Gesellschaft

Bond¹

2009

Contributions to the History of Concepts

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Ferdinand Tönnies's oeuvre Gemeinschaft und Gesellschaft, published in 1887, has been seminal for the social and human sciences in general, and is no less interesting for intellectual historians and theoreticians of concept formation in particular. Tönnies subscribed to the belief that terms could be rendered less ambiguous, defi ning the words Gemeinschaft and Gesellschaft more narrowly than their contemporary usage. In so doing, he sought to reconcile a heterogeneous agenda initially consisting in off ering a diagnosis of vast historical developments and later consisting in providing heuristic tools to analyze individual relationships. Th is article examines the origins of the concepts and their politicized transformation prior to and subsequent to the publication of his work. As such, it takes on the transformation of Gemeinschaft during the romantic era and its revival by Germany's nationalist right wing and contrasts it with its appropriation by left-leaning communitarian movements in the English-speaking world. Th e polysemy of the terms in the German language accounts for their semantic evolution, for amalgamations of meanings within Tönnies's conceptual system, and for conundrums in translating the work into English or French. Although the terms were erroneously supposed to have been immediately applicable as ideal types, their adaptation, inter alia by Max Weber or by Talcott Parsons in the form of pattern variables, has been important in the reception of Tönnies's work in the social sciences.

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Effects of Ethanol on Voltage-Dependent Calcium Channel Function

Leslie¹

1995

The Pharmacology of Alcohol Abuse

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ω-Conotoxin increases sleep time following ethanol injection

Cited by 5 publications

References 32 publications

A Blocker of N- and T-type Voltage-Gated Calcium Channels Attenuates Ethanol-Induced Intoxication, Place Preference, Self-Administration, and Reinstatement

A Blocker of N- and T-type Voltage-Gated Calcium Channels Attenuates Ethanol-Induced Intoxication, Place Preference, Self-Administration, and Reinstatement

Gemeinschaft und Gesellschaft

Effects of Ethanol on Voltage-Dependent Calcium Channel Function

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