ω-6/ω-3 fatty acid ratio as an essential predictive biomarker in the management of type 2 diabetes mellitus

Shetty, Shilpa; N, Suchetha Kumari; Shetty, Praveen

doi:10.1016/j.nut.2020.110968

Cited by 30 publications

(28 citation statements)

References 31 publications

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“…In the current study, we observed that PUFAR was positively related to the presence of DM (Supplementary Table 5). This finding was consistent with previous reports [29] while quite contrary to the negative relationship between PUFAR and DR illustrated in our study. It has been generally accepted that high PUFAR promotes the pathogenesis of many chronic diseases [31] .…”

Section: Discussionsupporting

confidence: 93%

“…Two clinical trials confirmed that LA-rich diet could inhibit the development of microangiopathy or the deterioration of DR [12,13]. While a crosssectional study observed that higher LA was positively associated with the risk of DM [29]. This variability between findings can variously be attributed to the complex interplay of metabolic factors and their different disease statuses.…”

Section: Discussionmentioning

confidence: 96%

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Serum ω-6/ω-3 polyunsaturated fatty acids ratio and diabetic retinopathy: A propensity score matching based case-control study in China

et al. 2021

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Background Optimal ω-6/ω-3 polyunsaturated fatty acids ratio (PUFAR) is reported to exert protective effects against chronic diseases. However, data on PUFAR and diabetic retinopathy (DR) remains scarce. We aimed to thoroughly quantify whether and how PUFAR was related to DR as well as its role in DR detection. Methods This two-centre case-control study was conducted from August 2017 to June 2018 in China, participants were matched using a propensity score matching algorithm. We adopted multivariable logistic regression models and restricted cubic spline analyses to estimate the independent association of PUFAR with DR, adjusting for confounders identified using a directed acyclic graph. The value of PUFAR as a biomarker for DR identification was further evaluated by receiver operating characteristic analyses and Hosmer-Lemeshow tests. Findings An apparent negative relationship between PUFAR and DR was observed. Adjusted odds of DR decreased by 79% (OR: 0·21, 95% CI: 0·10–0·40) with an interquartile range increase in PUFAR. Similar results were also obtained in tertile analysis. As compared to those in the 1st tertile of PUFAR, the adjusted odds of DR decreased by 76% (OR: 0·24, 95% CI: 0·08–0·66) and 93% (OR: 0·07, 95% CI: 0·03–0·22) for subjects in the 2nd and 3rd tertiles, respectively. Good calibration and discrimination of the PUFAR associated predictive model were detected and PUFAR = 35 would be an ideal cut-off value for DR identification. Interpretation Our results suggest that serum PUAFR is inversely associated with DR. Although PUFAR-alteration is not observed amongst different stages of DR, it can serve as an ideal biomarker in distinguishing patients with DR from those without DR. Funding This study was funded by Natural Science Foundation of Zhejiang Province, Zhejiang Basic Public Welfare Research Project, the Major Project of the Eye Hospital of Wenzhou Medical University, and the Academician's Science and Technology Innovation Program in Zhejiang province. Part of this work was also funded by the National Nature Science Foundation of China, and Research Project for College Students in Wenzhou Medical University.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 96%

Serum ω-6/ω-3 polyunsaturated fatty acids ratio and diabetic retinopathy: A propensity score matching based case-control study in China

et al. 2021

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“…It is reported that D6D, elongase and D5D play a key role in the metabolic pathway of LA ( 29 ). Abundant evidences containing animal experiment ( 30 ), cross-sectional research ( 23 ) and cohort study ( 24 ) reveal that abnormal PUFAs metabolism in diabetic patients is closely related to the activities of desaturation and elongase depending on the comparison between diabetic patients and their counterparts. In the current study, the association between the levels of PUFAs and the presence of DR do not achieve significant level.…”

Section: Discussionmentioning

confidence: 99%

“…The content of n-6 PUFAs were expressed as ratios with n-3 PUFAs to correct the influence of n-3 PUFAs. In addition, the activities of desaturase and elongase are closely linked to the metabolism of n-6 PUFAs, so we have also explored the activities of desaturase and elongase, in which these activities are estimated from the product-to-precursor ratios of some individual fatty acids in serum ( 23 ). The 18:3 n-6/18:2 n-6 (GLA/LA), 20:4 n-6/20:3 n-6 (AA/DGLA) and 20:3 n-6/18:3 n-6 (DGLA/GLA) are commonly suggested to represent the activities of D6D, delta 5-desaturase (D5D) and elongase, respectively ( 24 ).…”

Section: Design and Methodsmentioning

confidence: 99%

Association of n-6 PUFAs with the risk of diabetic retinopathy in diabetic patients

Wang

Zuo

et al. 2020

Endocrine Connections

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Diabetic retinopathy (DR), the most common microvascular complication of diabetes and leading cause of visual impairment in adults worldwide, is suggested to be linked to abnormal lipid metabolism. The present study aims to comprehensively investigate the relationship between n-6 polyunsaturated fatty acids (PUFAs) and DR. This was a propensity score matching based case-control study, including 69 pairs of DR patients and type 2 diabetic patients without DR with mean age of 56.7 ± 9.2 years. Five n-6 PUFAs were determined by UPLC-ESI-MS / MS system. Principle component regression (PCR) and multiple conditional logistic regression models were used to investigate the association of DR risk with n-6 PUFAs depending on independent training and testing sets, respectively. According to locally weighted regression model, we observed obvious negative correlation between levels of five n-6 PUFAs (linoleic acid, γ-linolenic acid, eicosadienoic acid, dihomo-γ-linolenic acid and arachidonic acid) and DR. Based on multiple PCR model, we also observed significant negative association between the five n-6 PUFAs and DR with adjusted OR (95% CI) as 0.62 (0.43,0.87). When being evaluated depending on the testing set, the association was still existed, and PCR model had excellent classification performance, in which area under the curve (AUC) was 0.88 (95%CI: 0.78, 0.99). In addition, the model also had valid calibration with a non-significant Hosmer-Lemeshow Chi-square of 9.44 (P = 0.307) in the testing set. n-6 PUFAs were inversely associated with the presence of DR, and the principle component could be potential indicator in distinguishing DR from other T2D patients.

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“…Based on the above, the present study aimed to evaluate the effect of information on the addition of omega-3 and its health benefits on acceptance in hedonic thresholds of compromised acceptance and hedonic rejection, in dairy desserts, flan type, strawberry flavor added with Omega 3 (EPA e DHA). Importantly, omega-3 plays important roles in the development and functioning of organs, in addition to being a precursor of anti-inflammatory mediators, and acts in the prevention of heart disease Research, Society and Development, v. 10, n. 15, e289101522660, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i15.22660 3 (Maki et al, 2017;Maurício et al, 2017;Adkins & Kelley 2010), diabetes (Shilpa et al, 2020), Alzheimer's (Yan et al, 2020Belkouch et al, 2016), anemia (Daak et al, 2020) and Parkinson's (Tamtaji et al, 2019), in addition to cancer control (Abedi et al, 2020;Story, 2020)and cholesterol reduction (Olson & Aryana, 2017;Comunian & Favaro-Tindade, 2016;Let et al, 2007). However, because it gives an unpleasant taste to foods, its insertion becomes a challenge for the food industry.…”

Section: Introductionmentioning

confidence: 99%

Effect of a health claim on consumer acceptance of milk-based dessert containing omega-3

Madalão

Simiqueli

Filho

et al. 2021

RSD

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This study was to evaluate the influence of information on the addition of omega-3 and its health benefits in the acceptance of dairy dessert. The hedonic thresholds methodology was applied in two trials: blind and open-label. In the blind trial, no information was provided to consumers regarding the formulation of the flans. In the open-label trial, consumers received the information on the addition of omega-3 and its health benefits. The value of compromised acceptance threshold (CAT) was not influenced by the information on the addition of omega-3 and its health benefits. However, there was a high increase in the value of hedonic rejection threshold (HRT) when the consumers were informed of the benefits of omega-3, and it was possible to increase the addition of the compound in the flans by up to 21.03% without causing product rejection, confirming the positive effect of information on health benefits in accptance.

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ω-6/ω-3 fatty acid ratio as an essential predictive biomarker in the management of type 2 diabetes mellitus

Cited by 30 publications

References 31 publications

Serum ω-6/ω-3 polyunsaturated fatty acids ratio and diabetic retinopathy: A propensity score matching based case-control study in China

Serum ω-6/ω-3 polyunsaturated fatty acids ratio and diabetic retinopathy: A propensity score matching based case-control study in China

Association of n-6 PUFAs with the risk of diabetic retinopathy in diabetic patients

Effect of a health claim on consumer acceptance of milk-based dessert containing omega-3

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