ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity

Bi, Xinyun; Li, Fanghong; Liu, Shanshan; Jin, Yan; Zhang, Xin; Yang, Tao; Dai, Yifan; Li, Xiaoxi; Zhao, Allan Z.

doi:10.1172/jci87388

Cited by 100 publications

(118 citation statements)

References 76 publications

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“…Other lipid classes including sphingosine-1-phosphate, omega-3 fatty acids, and resolvins have also been shown to reduce autoimmunity and improve β cell function in NOD mice (16,18,23). However, the results from studies in humans are mixed.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, PAHSA treatment potentiated GSIS ( Figure 1G), which resulted in lower glycemia after glucose gavage ( Figure 1H) compared with vehicle treatment. In addition, PAHSA-treated NOD mice were more glucose tolerant than were vehicle-treated mice, as evidenced by lower glucose excursion during the oral glucose tolerance test (OGTT) and a reduced AUC led to NOD mouse studies, which showed that dietary omega-3 fatty acids or enhancing endogenous production of omega-3 fatty acids reduces the incidence of T1D by blocking the development of autoimmunity and promoting islet regeneration (23). These lipids also prevent lymphocyte infiltration into regenerated islets in NOD mice (23).…”

Section: Introductionmentioning

confidence: 99%

“…In addition, PAHSA-treated NOD mice were more glucose tolerant than were vehicle-treated mice, as evidenced by lower glucose excursion during the oral glucose tolerance test (OGTT) and a reduced AUC led to NOD mouse studies, which showed that dietary omega-3 fatty acids or enhancing endogenous production of omega-3 fatty acids reduces the incidence of T1D by blocking the development of autoimmunity and promoting islet regeneration (23). These lipids also prevent lymphocyte infiltration into regenerated islets in NOD mice (23). Overall, although the results from studies using antiinflammatory lipids in NOD mice are promising, studies in humans who have an increased risk for or established T1D have either been negative or inconclusive, often due to challenges with the experimental design (24).…”

Section: Introductionmentioning

confidence: 99%

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PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

Syed¹,

Celis²,

Mohan³

et al. 2019

Journal of Clinical Investigation

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

Syed¹,

Celis²,

Mohan³

et al. 2019

Journal of Clinical Investigation

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“…Gene n-3 PUFAs induce apoptosis and autophagy in prostate cancer cell lines through the AKT-mTOR signaling pathways [22]. In addition to apoptosis, PUFAs suppress inflammatory process and modulate CD4+ T-cell differentiation [23]. DHA and EPA reduce viability and induce apoptosis in gastric cancer cells through caspase-3.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Omega Fatty Acids on Bcl-2 Gene Expression and Protein Production in Cancerous Gastric Tissue

Ghanbarzadeh

Mohaddes

2017

mcij

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Introduction: Gastric cancer is the fourth common cancer and the second leading cause of death from cancer worldwide. Omega fatty acids are a group of non-saturated fatty acids of long chains derive from linolenic, linoleic and oleic fatty acids. The current study aimed at examining the possible effects of oral administration of omega-3, -6 and -9 fatty acids on gastric cancer cell apoptosis in patients with gastric adenocarcinoma via the evaluation of BCL2 gene and protein expression. Methods: In the present case-control study, a total of 34 patients with gastric cancer referring to the Endoscopy Clinic at Tabriz University of Medical Sciences were selected and divided into 2 groups (n = 17). In group 1, patients were treated by platinum drugs without any supplementation and in group 2, patients were treated by platinum drugs supplemented with omega-3, -6 and -9 fatty acids over 3 courses, which each lasted 3 weeks. After stomach biopsy, RNA extraction, cDNA synthesis and real-time polymerase chain reaction (RT-PCR) were performed. Results:The results showed that Bcl-2 gene and BCL2 protein expression in patients who received omega-3, -6 and -9 fatty acids with chemotherapy was lower than those of the ones who not received omega fatty acids. Also, there was a significant decrease in Bcl-2 gene expression (P < 0.05). Conclusions:The oral administration of omega-3, -6 and -9 fatty acids with the chemotherapeutic drug cis-platinum in patients with gastric adenocarcinoma could decrease Bcl-2 gene expression and BCL2 protein production in the cancerous gastric tissue.

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“…The researches show that the regeneration of pancreatic islets are ultimate goals for the complete cure of type 1 diabetes [30]. Herein, we reviewed the therapeutic effects of iPS cells on type 1 diabetes.…”

Section: Progress In Dm Therapy Researchmentioning

confidence: 99%

Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols

Chen

2017

Journal of Diabetes Research

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Diabetes mellitus is a chronic disease that threatens human health. The disease is caused by a metabolic disorder of the endocrine system, and long-term illness can lead to tissue and organ damage to the cardiovascular, endocrine, nervous, and urinary systems. Currently, the disease prevalence is 11.4%, the treatment rate is 48.2%, and the mortality rate is 2.7% worldwide. Comprehensive and effective control of diabetes, as well as the use of insulin, requires further study to develop additional treatment options. Here, we reviewed the current reprogramming of somatic cells using specific factors to induced pluripotent stem (iPS) cells capable of repairing islet β cell damage in diabetes patients to treat patients with type 1 diabetes mellitus. We also discuss the shortcomings associated with clinical use of iPS cells. Additionally, certain polyphenols found in spices might improve glucose homeostasis and insulin resistance in diabetes patients, thereby constituting promising options for the treatment of type 2 diabetes.

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ω-3 polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity

Cited by 100 publications

References 76 publications

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice

The Effect of Omega Fatty Acids on Bcl-2 Gene Expression and Protein Production in Cancerous Gastric Tissue

Treatment of Diabetes Mellitus Using iPS Cells and Spice Polyphenols

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