ω‐3 Fatty Acids–Supplemented Parenteral Nutrition Decreases Hyperinflammatory Response and Attenuates Systemic Disease Sequelae in Severe Acute Pancreatitis: A Randomized and Controlled Study

Wang, Xinying; Li, Weiqin; Li, Ning; Li, Jieshou

doi:10.1177/0148607108316189

Cited by 125 publications

(124 citation statements)

References 23 publications

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“…The influence of fish oil on inflammatory processes and on immune function in critically ill patients is not yet clear. Similarly, the impact of fish oil on clinical endpoints like infections, length of ICU and hospital stay, and mortality is not clear, since there are too few studies and those that are available (75)(76)(77) report contradictory findings or do not have a satisfactory design. One important factor, highlighted by the study of Heller et al, is the dose of fish oil required to influence clinical outcomes.…”

Section: Studies Of Parenteral Fish Oil In Critically Ill Patientsmentioning

confidence: 99%

Rationale and use of n-3 fatty acids in artificial nutrition

Calder

2010

Proc. Nutr. Soc.

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Lipids traditionally used in artificial nutrition are based on n-6 fatty acid-rich vegetable oils like soyabean oil. This may not be optimal because it may present an excessive supply of linoleic acid. One alternative to the use of soyabean oil is its partial replacement by fish oil, which contains n-3 fatty acids. These fatty acids influence inflammatory and immune responses and so may be useful in particular situations where those responses are not optimal. Fish oil-containing lipid emulsions have been used in parenteral nutrition in adult patients post-surgery (mainly gastrointestinal). This has been associated with alterations in patterns of inflammatory mediators and in immune function and, in some studies, a reduction in length of intensive care unit (ICU) and hospital stay. Perioperative administration of fish oil may be superior to post-operative. Parenteral fish oil has been used in critically ill adults. Here the influence on inflammatory processes, immune function and clinical endpoints is not clear, since there are too few studies and those that are available report contradictory findings. Fish oil is included in combination with other nutrients in various enteral formulas. In post-surgical patients and in those with mild sepsis or trauma, there is clinical benefit from a formula including fish oil and arginine. A formula including fish oil, borage oil and antioxidants has demonstrated marked benefits on gas exchange, ventilation requirement, new organ failures, ICU stay and mortality in patients with acute respiratory distress syndrome, acute lung injury or severe sepsis.

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Section: Studies Of Parenteral Fish Oil In Critically Ill Patientsmentioning

confidence: 99%

Rationale and use of n-3 fatty acids in artificial nutrition

Calder

2010

Proc. Nutr. Soc.

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“…Estudos experimentais e clínicos têm mostrado o efeito favorável da suplementação de EL rica em ácidos graxos ômega-3 no tratamento da pancreatite aguda [40][41][42][43][44][45][46][47] , no entanto persistem lacunas no conhecimento do comportamento de marcadores inflamatórios perante esta modalidade de tratamento. Em ratos, sob infusão parenteral de emulsão lipídica de óleo de peixe, rica em ômega-3, e posteriormente induzidos à pancreatite aguda, estudamos a sobrevida e cinética de marcadores da resposta inflamatória sistêmica.…”

Section: Discussionunclassified

“…Estudos clínicos e experimentais têm mostrado efeito positivo da infusão parenteral de EL de OP, como fonte de AG n-3, em PA [40][41][42][43][44][45][46] .…”

Section: Influência De El De Op Na Pancreatite Agudaunclassified

“…Nesse sentido, aplicação de terapia nutricional com nutrientes capazes de modular funções imunológicas e inflamatórias torna-se de grande interesse. Ácidos graxos ômega-3, contidos em EL de OP, fazem parte desse grupo de nutrientes e seu uso está associado à manutenção ou melhora de funções imunológicas e modulação favorável de marcadores inflamatórios na PA [40][41][42][43][44][45][46][47] .…”

Section: Racional E Justificativa Do Estudo Racional E Justificativa unclassified

“…O uso de EL de OP com seus potenciais efeitos anti-inflamatórios poderia minimizar a inflamação da PA [40][41][42][43][44][45][46][47] . 14 Neste sentido, o presente estudo pretende, de forma pioneira, avaliar experimentalmente a repercussão da infusão parenteral prévia de EL de OP puro na resposta inflamatória sistêmica e sobrevida em modelo de inflamação aguda representado por PA induzida por taurocolato de sódio a 3%.…”

Section: Racional E Justificativa Do Estudo Racional E Justificativa unclassified

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Repercussão do uso parenteral prévio de emulsão lipídica de óleo de peixe sob a resposta inflamatória sistêmica e sobrevida em modelo experimental de pancreatite aguda

Garla¹

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Pharmacological interventions for acute pancreatitis

Moggia

Koti

Belgaumkar

et al. 2017

Cochrane Database of Systematic Reviews

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Very low-quality evidence suggests that none of the pharmacological treatments studied decrease short-term mortality in people with acute pancreatitis. However, the confidence intervals were wide and consistent with an increase or decrease in short-term mortality due to the interventions. We did not find consistent clinical benefits with any intervention. Because of the limitations in the prognostic scoring systems and because damage to organs may occur in acute pancreatitis before they are clinically manifest, future trials should consider including pancreatitis of all severity but power the study to measure the differences in the subgroup of people with severe acute pancreatitis. It may be difficult to power the studies based on mortality. Future trials in participants with acute pancreatitis should consider other outcomes such as complications or health-related quality of life as primary outcomes. Such trials should include health-related quality of life, costs, and return to work as outcomes and should follow patients for at least three months (preferably for at least one year).

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ω‐3 Fatty Acids–Supplemented Parenteral Nutrition Decreases Hyperinflammatory Response and Attenuates Systemic Disease Sequelae in Severe Acute Pancreatitis: A Randomized and Controlled Study

Cited by 125 publications

References 23 publications

Rationale and use of n-3 fatty acids in artificial nutrition

Rationale and use of n-3 fatty acids in artificial nutrition

Repercussão do uso parenteral prévio de emulsão lipídica de óleo de peixe sob a resposta inflamatória sistêmica e sobrevida em modelo experimental de pancreatite aguda

Pharmacological interventions for acute pancreatitis

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