π–π conjugation promoted nanocatalysis for cancer therapy based on a covalent organic framework

Abstract

The production of reactive oxygen species (ROS) to elicit lethal cellular oxidative damage is an attractive pathway to kill cancer, but it is still hindered by the low ROS production...

Bioinspired Electron Polarization of Nanozymes with a Human Self‐Generated Electric Field for Cancer Catalytic Therapy

“…[ 18 ] COF‐CNT was prepared according to the previously reported method with slight modifications. [ 17 ] The detailed protocol is provided in the Supporting Information. To synthesize PC, COF‐CNT (1 mg mL −1 ) was added to the PEDOT:PSS solution, and the subsequent procedure was the same as that employed for PEDOT:PSS.…”

“…First, we rationally fabricated a 1D metal/covalent organic framework (COF) coated on a carbon nanotube (denoted as COF‐CNT) as a prototypical example of an efficient nanozyme. [ 17 ] In COF‐CNT, ferriporphyrin (TAPP‐Fe) was used as a building module of COF, and 2,5‐dihydroxyterephthalaldehyde (DHPA) was employed as the linker, forming imine bonds with TAPP‐Fe ( Figure A). TAPP‐Fe has a molecular structure analogous to that of heme, in which atomically dispersed Fe as the catalytic active center is coordinated in the middle of the porphyrin ring.…”

Nanomedicine Strategies for Heating “Cold” Ovarian Cancer (OC): Next Evolution in Immunotherapy of OC

“…MIL‐88A was used as a safe and efficient MC carrier because MIL‐88A efficiently bonded DNA by Fe 3+ ‐phosphate coordination and electrostatic interactions. [ 118 , 119 , 120 ] After an intraperitoneal injection of MC‐MIL‐88A, catumaxomab highly and consistently expressed with the peak concentration of 77.3 ng mL −1 (serum) and 51.0 ng mL −1 (ascites) in the OC xenograft model (Figure 8C ). At OC sites, MC‐MIL‐88A effectively increased CD3+ T cell infiltration, and the median survival time of model mice was extended from 26 to 39 days.…”

Piezotronic Effect-Augmented Cu2–xO–BaTiO3 Sonosensitizers for Multifunctional Cancer Dynamic Therapy

“…Functional nanomaterials-enabled dynamic therapies can trigger the death of target cells through the generation of excessive toxic reactive oxygen species (ROS), showing prominent advantages of noninvasiveness and high selectivity for cancer therapy. − Among the different methods to generate ROS, photodynamic therapy (PDT) that mainly relies on photosensitizers (PSs) and light irradiation to generate singlet oxygen ( 1 O 2 ) has been successfully applied in clinical treatment of skin cancer and esophageal cancer. , Nevertheless, the limited tissue penetration depth of light restricts its application in the treatment of deep and large tumors. Chemodynamic therapy (CDT) has been developed more recently, which utilizes endogenous hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment (TME) to produce hydroxyl radicals (•OH) through transition metal containing nanomaterial-catalyzed Fenton or Fenton-like reactions. , However, the insufficient acidity and H 2 O 2 in the TME limit the Fenton reaction rate and therapeutic efficiency, , which is the main stumbling block of CDT.…”

“…1−5 Among the different methods to generate ROS, photodynamic therapy (PDT) that mainly relies on photosensitizers (PSs) and light irradiation to generate singlet oxygen ( 1 O 2 ) has been successfully applied in clinical treatment of skin cancer and esophageal cancer. 6,7 Nevertheless, the limited tissue penetration depth of light restricts its application in the treatment of deep and large tumors. Chemodynamic therapy (CDT) has been developed more recently, which utilizes endogenous hydrogen peroxide (H 2 O 2 ) in the tumor microenvironment (TME) to produce hydroxyl radicals (•OH) through transition metal containing nanomaterial-catalyzed Fenton or Fenton-like reactions.…”