Μultiple myeloma developing after imatinib mesylate therapy for chronic myeloid leukemia

Development of Multiple Myeloma in a Patient with Chronic Myeloid Leukemia While on Treatment with Imatinib Mesylate for 65 Months

“…We report here on only the third case of the development of MM in a patient with CML on treatment with imatinib mesylate [8,9], and to our knowledge, this is the first case in a patient who received imatinib as first-line treatment.…”

Uncommon case of chronic myeloid leukemia with multiple myeloma

“…Thus, the abnormal cell types in CML and MM are quite different, being myeloid and lymphoplasmacytic cells, respectively. The coexistence of CML and MM is an extremely uncommon event that has previously been reported in only 12 cases [1][2][3][4][5][6][7][8][9][10][11][12]. In this report, we describe a patient who developed asymptomatic MM while being treated for CML with imatinib mesylate.…”

“…We suspect that the clinical course of this patient was mainly affected by imatinib mesylate, but we cannot rule out the possibility that the pathophysiological effects of one disease may have contributed to the other. In the literature, three of the four patients who first had CML and then MM received imatinib mesylate before MM was diagnosed [5][6][7]. Furthermore, MM was reported to have developed in an imatinib mesylate-treated patient with a gastrointestinal stromal tumor [26].…”

“…Twelve cases in which CML and MM coexisted have been reported in the literature (Table 1) [1][2][3][4][5][6][7][8][9][10][11][12]. A case of chronic neutrophilic leukemia [14][15][16][17] that was negative for the Ph chromosome and had a high NAP score, and a case of monoclonal gammopathy of undetermined significance [18,19], were excluded from this category.…”

“…A case of chronic neutrophilic leukemia [14][15][16][17] that was negative for the Ph chromosome and had a high NAP score, and a case of monoclonal gammopathy of undetermined significance [18,19], were excluded from this category. In four of the 12 previous cases (patients [1][2][3][4], CML and MM were diagnosed simultaneously; the diagnosis of CML preceded that of MM in four cases (patients [5][6][7][8], and the diagnosis of MM preceded that of CML in the remaining four cases (patients 9-12). In the latter eight cases, the interval between the diagnosis of each disease ranged from 1 year and 2 months to 9 years and 5 months.…”