μ-Opioids disinhibit and κ-opioids inhibit serotonin efflux in the dorsal raphe nucleus

Tao, Rui; Auerbach, Sidney B.

doi:10.1016/j.brainres.2005.04.076

Cited by 49 publications

(34 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…U50,488-induced CPA was blocked by intra-dorsal raphe nuclei (DRN) microinjections of nor-BNI, suggesting that DRN KOR activation is necessary for U50,488-mediated aversion [256]. [257,258]. As previously mentioned, KOR and D2 autoreceptors regulate monoamine function by affecting monoamine transporter function.…”

Section: Kor-serotonin (5-ht) Interactions and Conditioned Aversionmentioning

confidence: 85%

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

Tejeda

Shippenberg

Henriksson

2011

Cell. Mol. Life Sci.

145

144

View full text Add to dashboard Cite

The dynorphin/κ-opioid receptor system has been implicated in the pathogenesis and pathophysiology of several psychiatric disorders. In the present review, we present evidence indicating a key role for this system in modulating neurotransmission in brain circuits that subserve mood, motivation, and cognitive function. We overview the pharmacology, signaling, post-translational, post-transcriptional, transcriptional, epigenetic and cis regulation of the dynorphin/κ-opioid receptor system, and critically review functional neuroanatomical, neurochemical, and pharmacological evidence, suggesting that alterations in this system may contribute to affective disorders, drug addiction, and schizophrenia. We also overview the dynorphin/κ-opioid receptor system in the genetics of psychiatric disorders and discuss implications of the reviewed material for therapeutics development.

show abstract

Section: Kor-serotonin (5-ht) Interactions and Conditioned Aversionmentioning

confidence: 85%

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

Tejeda

Shippenberg

Henriksson

2011

Cell. Mol. Life Sci.

145

144

View full text Add to dashboard Cite

show abstract

“…Site-specific administration of the KOR agonist U50,488 into the DR decreased extracellular serotonin by approximately 30% (Tao & Auerbach 2005). Behaviorally, KORs in the DR have been shown to be necessary for stress related behaviors.…”

Section: Circuitrymentioning

confidence: 99%

Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

Crowley

Kash

2015

Progress in Neuro-Psychopharmacology and Biological Psychiatry

103

View full text Add to dashboard Cite

Kappa opioid receptors (KORs) in the central nervous system have been known to be important regulators of a variety of psychiatry illnesses, including anxiety and addiction, but their precise involvement in these behaviors is complex and has yet to be fully elucidated. Here, we briefly review the pharmacology of KORs in the brain, including KOR's involvement in anxiety, depression, and alcohol addiction. We also review the known neuronal circuitry impacted by KOR signaling, and interactions with corticotrophin-releasing factor (CRF), another key peptide in anxiety-related illnesses, as well as the role of glucocorticoids. We suggest that KORs are a promising therapeutic target for a host of neuropsychiatric conditions.

show abstract

“…Stress and opioids converge on the DRN to regulate 5-HT neurotransmission [26]. It has been demonstrated that the DRN neurons express the major opioid receptors; mu-opioid receptors inhibit GABAergic synaptic input and thus disinhibit 5-HT neurons in the DRN [27]. The LC, which represents the major noradrenergic cluster in the brain, contains a high density of somatodendritic mu-opioid receptors.…”

Section: Discussionmentioning

confidence: 99%

ERK1/2 Phosphorylation in the Rat Supraoptic Nucleus, Dorsal Raphe Nucleus, and Locus Coeruleus Neurons Following Noxious Stimulation to the Hind Paw

Donnerer

Liebmann²

2015

Pharmacology

View full text Add to dashboard Cite

Phospho-ERK1/2 (pERK1/2) fluorescence-immunohistochemistry is specifically well suited to mirror neuronal activity in the pain pathway at the cellular level. This study employed this method to visualize neuronal activity in 3 rat CNS nuclei following an acute noxious stimulation. The rat hind paw was stimulated either by heat or by a sequence of mustard oil and heat. Two min after the thermal stimulation or after the combined mustard oil and thermal stimulation, there was a significant increase in cells showing pERK1/2 immunoreactivity in the supraoptic nucleus (SON), in the dorsal raphe nucleus (DRN), and in the locus coeruleus (LC). Pretreatment with the opioid analgesic morphine or the N-methyl-D-aspartate antagonist MK-801 markedly attenuated ERK1/2 phosphorylation. These findings support the concept that the SON, the DRN, and the LC are integrated into pain processing at the hypothalamic and brain stem level.

show abstract

μ-Opioids disinhibit and κ-opioids inhibit serotonin efflux in the dorsal raphe nucleus

Cited by 49 publications

References 34 publications

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

The dynorphin/κ-opioid receptor system and its role in psychiatric disorders

Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

ERK1/2 Phosphorylation in the Rat Supraoptic Nucleus, Dorsal Raphe Nucleus, and Locus Coeruleus Neurons Following Noxious Stimulation to the Hind Paw

Contact Info

Product

Resources

About