“…The endogenous opioid system plays a key role in the mammalian reward circuit (e.g., Bozarth & Wise, 1981;DiFeliceantonio & Berridge, 2016;, and accumulating evidence links the opioid receptor (OR) system in the regulation of sexual desire and arousal (e.g., Nummenmaa et al, 2022). Opiates are potent suppressors of sexual behaviors in both humans and animals (e.g., Pfaus & Gorzalka, 1987), and particularly μ-opioid receptor (MOR) agonists decrease human sexual desire and pleasure acutely and following chronic use (Birke et al, 2019).…”