κ-carrageenan-C-phycocyanin based smart injectable hydrogels for accelerated wound recovery and real-time monitoring

Dev, Atul; Mohanbhai, Soni Jignesh; Kushwaha, Avinash Chandra; Sood, Ankur; Sardoiwala, Mohammed Nadim; Choudhury, Subhasree Roy; Karmakar, Surajit

doi:10.1016/j.actbio.2020.03.023

Cited by 74 publications

(36 citation statements)

References 51 publications

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“…Thus, biocompatibility evaluation is an important indicator of the safety of drug delivery systems and scaffolds. The assessment applied to polysaccharides-based hydrogels usually involves chemical analysis, tissue cultures, and animal tests [ 7 , 8 , 249 , 250 , 251 , 252 , 253 , 254 , 255 ]. However, risk-free drug delivery systems do not exist, so those tests aim to screen systems or materials with maximum benefits and minimum risks.…”

Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

“…Mice in the experimental group were injected with hydrogel solutions, while those in the control group were injected with a placebo [ 249 ]. Furthermore, a hemocompatibility test is required to evaluate the blood compactivity of hydrogel devices that contact blood directly [ 8 , 254 , 255 ]. The hemolysis testing method measures the damage to red blood cells caused by the samples, and the thrombus testing method detects the formation of blood coagulation [ 257 ].…”

Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

“…The gelation time was determined as the time when the mixture stopped flowing upon the tube inversion. Additionally, oscillatory experiments and creep tests of rheological characterization have been employed to evaluate their injectability and stability [ 8 , 223 ].…”

Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

“…In 1960, Wichterle and Lim published a landmark article in the scientific journal, Nature , in which synthetic poly(2-hydroxyethyl methacrylate) gels were designed as soft contact lenses [ 4 ]. These promising materials have been widely applied in the fields of biotechnology, including drug delivery [ 1 , 2 ], tissue engineering [ 5 , 6 ], wound dressing [ 7 , 8 ], agrochemicals application [ 9 , 10 ], separation [ 11 , 12 ], food packaging [ 13 , 14 ], and cosmetics and personal care products [ 15 , 16 ]. The hydrophilic polymer structures can be designed using physical and/or chemical crosslinking methods.…”

Section: Introductionmentioning

confidence: 99%

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Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Lin

Jiao²,

Kermanshahi-pour

2022

Marine Drugs

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Hydrogels are three-dimensional crosslinked hydrophilic polymer networks with great potential in drug delivery, tissue engineering, wound dressing, agrochemicals application, food packaging, and cosmetics. However, conventional synthetic polymer hydrogels may be hazardous and have poor biocompatibility and biodegradability. Algal polysaccharides are abundant natural products with biocompatible and biodegradable properties. Polysaccharides and their derivatives also possess unique features such as physicochemical properties, hydrophilicity, mechanical strength, and tunable functionality. As such, algal polysaccharides have been widely exploited as building blocks in the fabrication of polysaccharide-based hydrogels through physical and/or chemical crosslinking. In this review, we discuss the extraction and characterization of polysaccharides derived from algae. This review focuses on recent advances in synthesis and applications of algal polysaccharides-based hydrogels. Additionally, we discuss the techno-economic analyses of chitosan and acrylic acid-based hydrogels, drawing attention to the importance of such analyses for hydrogels. Finally, the future prospects of algal polysaccharides-based hydrogels are outlined.

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Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Section: Performance Of Seaweed Polysaccharide-based Hydrogelsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Lin

Jiao²,

Kermanshahi-pour

2022

Marine Drugs

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“…At present, the rheological properties and microstructure of protein-polysaccharide gels have been extensively studied [ 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ], but there was little research on the nonlinear rheological properties of phycocyanin and phycocyanin-polysaccharide gels [ 34 ]. Therefore, this article focuses on phycocyanin-polysaccharide gel, which is of great significance for studying nonlinear rheological properties and microstructure.…”

Section: Introductionmentioning

confidence: 99%

Effects of κ-Carrageenan and Guar Gum on the Rheological Properties and Microstructure of Phycocyanin Gel

Lei

Zhao

et al. 2022

Foods

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The effects of two polysaccharides on the performance and microstructure of phycocyanin gels were studied by choosing anionic polysaccharides (κ-carrageenan) and neutral polysaccharides (guar gum). The linear and nonlinear rheological properties and microstructure of the phycocyanin-polysaccharide composite gel were evaluated. The results show that both κ-carrageenan and guar gum can enhance the network structure of phycocyanin gel and weaken the frequency dependence. The sample with 0.4% κ-carrageenan has the highest gel strength. All samples exhibited Type I behavior (inter-cycling strain-thinning) and mainly elastic behavior. As the concentration of κ-carrageenan increases, hydrophobic interactions and disulfide bonds play an essential role in maintaining the three-dimensional structure of the gel. Too high a concentration of guar gum hinders the formation of protein disulfide bonds. This research can provide a theoretical basis for designing and developing new food products based on phycocyanin and different polysaccharides with ideal texture in the food industry.

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Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

Mao

Chen

Cai

et al. 2021

Adv Funct Materials

107

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Macrophage immunotherapy is an emerging treatment strategy that modulates the immune system to promote wound healing. The functionality and regeneration of tissue depend on spatially and temporally regulating the biophysical and biochemical microenvironmental with poorly understood mechanisms. Biomaterials are carefully crafted to display and deliver macrophage regulatory signals in a precise and near‐physiological way, serving as powerful artificial microenvironments in which to explore and direct the fate of macrophages. The review starts with discussing the classification and function of macrophages, and then introduces the polarization of macrophages in different microenvironments of conventional wounds and chronic wounds. Recent advances in biomaterials that balance the phenotypes of macrophages in wound healing are emphasized. Finally, looking ahead, the potential ability of biomaterial scaffolds to modulate immune signaling to produce an environment conducive to regeneration is discussed.

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κ-carrageenan-C-phycocyanin based smart injectable hydrogels for accelerated wound recovery and real-time monitoring

Cited by 74 publications

References 51 publications

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Algal Polysaccharides-Based Hydrogels: Extraction, Synthesis, Characterization, and Applications

Effects of κ-Carrageenan and Guar Gum on the Rheological Properties and Microstructure of Phycocyanin Gel

Advanced Biomaterials for Regulating Polarization of Macrophages in Wound Healing

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