η6-Arene complexes of ruthenium and osmium with pendant donor functionalities

Reiner, Thomas; Waibel, Markus; Marziale, Alexander N.; Jantke, Dominik; Kiefer, Florian; Fässler, Thomas F.; Eppinger, Jörg

doi:10.1016/j.jorganchem.2010.08.008

Cited by 22 publications

(8 citation statements)

References 67 publications

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“…The dinuclear dichloro-bridged complexes [(η 5 -Cp*)IrCl 2 ] 2 ( dimer 1 ) and [(η 5 -Cp xbiph )IrCl 2 ] 2 ( dimer 2 ) were synthesized by microwave heating of IrCl 3 and relative cyclopentadienyl ligand in absolute methanol . Dimeric μ-chloro-bridged complexes [(η 6 -bz-PA)RuCl 2 ] 2 (dimer 3) , [(η 6 -bz-BA)RuCl 2 ] 2 ( dimer 4) and [(η 6 - p -cym)RuCl 2 ] 2 (dimer 5 ) are readily formed upon conversion of 3′-(2,5-dihydrophenyl)propanol, 4′-(2,5-dihydrophenyl)butanol, and α-terpinene, respectively, with RuCl 3 under refluxing in absolute methanol (Scheme ). Complexes 1 – 5 were synthesized by reactions between the ligand BINAP and the dinuclear iridium/ruthenium precursors dimers 1 – 5 in methanol at ambient temperature.…”

Section: Resultsmentioning

confidence: 99%

Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing P^P-Chelating Ligands: A New Class of Potent Anticancer Agents with Unusual Redox Features

Tian

et al. 2018

Inorg. Chem.

109

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A series of half-sandwich Ir pentamethylcyclopentadienyl and Ru arene complexes containing P^P-chelating ligands of the type [(Cp/arene)M(P^P)Cl]PF, where M = Ir, Cp is pentamethylcyclopentadienyl (Cp*), or 1-biphenyl-2,3,4,5-tetramethyl cyclopentadienyl (Cp); M = Ru, arene is 3-phenylpropan-1-ol (bz-PA), 4-phenylbutan-1-ol (bz-BA), or p-cymene (p-cym), and P^P is 2,20-bis(diphenylphosphino)-1,10-binaphthyl (BINAP), have been synthesized and fully characterized, three of them by X-ray crystallography, and their potential as anticancer agents explored. All five complexes showed potent anticancer activity toward HeLa and A549 cancer cells. The introduction of a biphenyl substituent on the Cp* ring for the iridium complexes has no effect on the antiproliferative potency. Ruthenium complex [(η-p-cym)Ru(P^P)Cl]PF (5) displayed the highest potency, about 15 and 7.5 times more active than the clinically used cisplatin against A549 and HeLa cells, respectively. No binding to 9-MeA and 9-EtG nucleobases was observed. Although these types of complexes interact with ctDNA, DNA appears not to be the major target. Compared to iridium complex [(η-Cp*)Ir(P^P)Cl]PF (1), ruthenium complex (5) showed stronger ability to interfere with coenzyme NAD/NADH couple through transfer hydrogenation reactions and to induce ROS in cells, which is consistent with their anticancer activities. The redox properties of the complexes 1, 5, and ligand BINAP were evaluated by cyclic voltammetry. Complexes 1 and 5 arrest cell cycles at the S phase, Sub-G phase and G phase, respectively, and cause cell apoptosis toward A549 cells.

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Section: Resultsmentioning

confidence: 99%

Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing P^P-Chelating Ligands: A New Class of Potent Anticancer Agents with Unusual Redox Features

Tian

et al. 2018

Inorg. Chem.

109

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“…In 2013, based on more information, we presented a bonding scheme for structures in which bismuth polycations act as electron donors . Their coordination chemistry is apparently similar to that of Zintl anions, nido ‐carboranes, and arenes, but differ in detail because of the high atomic number of bismuth. Main‐group elements are well known to act as ligands for transition‐metal elements…”

Section: Introductionmentioning

confidence: 99%

Polyhedral Bismuth Polycations Coordinating Gold(I) with Varied Hapticity in a Homoleptic Heavy‐Metal Cluster

et al. 2016

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Shiny black, air-sensitive crystals of [Au(Bi-8)(2)](AlCl4)(5) were obtained from the reaction of AuCl, BiCl3, and bismuth in the ionic liquid [BMIm] Cl center dot 4AlCl(3) (BMIm = 1-n-butyl-3-methylimidazolium) at 180 degrees C. [Au(Bi-8)(2)](AlCl4)(5) crystallizes in the monoclinic space group P2(1)/n. In the heavy-metal cluster [Au(Bi-8)(2)](5+), two square-antiprismatic Bi-8(2+) polycations coordinate the gold(I) atom in eta(2)-and eta(4)-mode, respectively. Quantum chemical calculations demonstrate that both Bi-8(2+) polycations involve skeletal electrons for the donor bonding, which causes a widening of Bi-Bi distances compared with those in free Bi-8(2+)

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“…Utilizing this information, we were able to solve the structure of the heavily disordered compound Bi 39.67(7) Ru 2 Br 35.0(2) , containing the title cluster. We can now present a consistent bonding scheme for all known bismuth‐ruthenium‐halogenides, which resembles in many aspects the coordination chemistry of arenes,4–6 nido ‐carbaboranes,7 and Zintl anions 8–10…”

Section: Introductionmentioning

confidence: 92%

Cover Picture: Multistimuli‐Responsive Supramolecular Gels: Design Rationale, Recent Advances, and Perspectives (ChemPhysChem 12/2014)

Sun

Huang

et al. 2014

ChemPhysChem

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η6-Arene complexes of ruthenium and osmium with pendant donor functionalities

Cited by 22 publications

References 67 publications

Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing P^P-Chelating Ligands: A New Class of Potent Anticancer Agents with Unusual Redox Features

Half-Sandwich Iridium(III) and Ruthenium(II) Complexes Containing P^P-Chelating Ligands: A New Class of Potent Anticancer Agents with Unusual Redox Features

Polyhedral Bismuth Polycations Coordinating Gold(I) with Varied Hapticity in a Homoleptic Heavy‐Metal Cluster

Cover Picture: Multistimuli‐Responsive Supramolecular Gels: Design Rationale, Recent Advances, and Perspectives (ChemPhysChem 12/2014)

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