Επίδραση Της Ινσουλίνης Και Της Γλυκόζης Σε Ενδοκυτταρικούς Μηχανισμούς Μεταβίβασης Σήματος Και Στις Αθηρογόνες Ιδιότητες Των Μονοκυττάρων. Ρόλος Των Υποδοχέων Πολλαπλασιασμού Των Περοξυσωματίων (PPAR)

Abstract

Peripheral blood monocytes are playing a central role in atherosclerosis development. These cells bind in the vassal epithelium and migrate to the subendothelial space, where monocytes phagocytose oxidized low-density lipoproteins (oxLDL) through CD36 scavenger receptors and turn into foam cells. Foam cells formation is the first step in atherosclerosis development. Monocytes exposure in oxLDL activates the transcription of peroxisome proliferators-activated receptors γ (PPARγ). High glucose concentrations, insulin and a PPARγ agonist, rosiglitazone, are involved in the first steps of atherosclerosis development. Also, stimulation of monocyte Na + /H + exchanger (NHE1) activity, which is an important