ε-Aminocaproic Acid (EACA)

Gacko, Marek; Worowska, A

doi:10.2478/v10035-008-0059-5

Cited by 2 publications

(3 citation statements)

References 46 publications

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“…It splits C-end amino-acids from peptides and proteins, especially quickly if phenyloalanine residue occurs in the penultimate position, in a weakly acidic environment [12,[19][20][21]. Our results are in accord with this.…”

Section: Resultssupporting

confidence: 86%

“…Cathepsin A participates in protein degradation and activates/inactivates peptic hormones and biologically active peptides [20,22]. This enzyme has no endogenous inhibitors [23] and its peptidizing activity depends on the availability of the substrate, and a pH of between 4.5 and 5.5 [20,23]. In a pH of 7.0-7.5, cathepsin A shows amidazing and esterazing activity [22,24].…”

Section: Resultsmentioning

confidence: 99%

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Cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm

Siergiejuk¹,

Gacko²,

Worowska³

2011

Folia Histochem Cytobiol.

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Abstract:We evaluated the cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm. We compared this activity to that of a retracted blood clot homogenate. Cathepsin A of aneurysm parietal thrombus homogenate and blood clot homogenate showed the highest activity on Z-Phe-Ala. It was lower on Z-Phe-Phe, Z-Glu-Tyr, Z-Glu-Phe, Z-Gly-Phe, and the lowest activity was on Z-Gly-Ala. We conclude that cathepsin A's activity on a parietal thrombus of an aneurysm is much higher than blood clot cathepsin A activity. (Folia Histochemica et

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Section: Resultssupporting

confidence: 86%

Section: Resultsmentioning

confidence: 99%

Cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm

Siergiejuk¹,

Gacko²,

Worowska³

2011

Folia Histochem Cytobiol.

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“…The terminal elimination half-life for AMI-CAR (aminocaproic acid) is $2 to 3 hours. 45 Because reports of basic, experimental, and in vitro studies 27,46,47 suggested that TXA is 7 to 10 times more potent than ε-ACA, 48,49 previous studies have used very high doses of aminocaproic acid (7-10 g) to try to equate the pharmacological effect of both drugs; however, the dose of ε-ACA that is the optimal equivalent to the TXA dose has not been established. Boese et al, 2017 use an equivalence of 7 g of ε-ACA with 1 g of TXA administered intravenously, found that there were no clinically significant differences regarding transfusion rates and blood loss in postoperated patients of a total knee arthroplasty.…”

Section: Discussionmentioning

confidence: 99%

First Comparative Study of the Effectiveness of the Use of Tranexamic Acid against ε-Aminocapróic Acid via the Oral Route for the Reduction of Postoperative Bleeding in TKA: A Clinical Trial

et al. 2019

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Total primary knee replacement results in significant postoperative bleeding. There are reports that 20 to 50% of the patients require a blood transfusion, which has been related to many complications, resulting in the search for strategies to reduce bleeding. The use of oral antifibrinolytics is becoming a low cost and safe way of achieving this goal. The hypothesis of this study was that the use of oral aminocaproic acid could provide similar results to the use of oral tranexamic acid (TXA). The purpose was to compare the effects of oral aminocaproic acid as a hemostatic agent versus the use of oral TXA administered in multiple doses pre and postsurgery in patients undergoing total primary knee replacement. We enrolled 92 patients that were randomly divided into two groups: received three doses of aminocaproic acid (2,000 mg per dose) or three doses of oral TXA (1,300 mg per dose). The drugs were administered according to the following schedule: 2 hours before surgery and 6 and 12 hours after surgery. The variables that were analyzed to compare the effectiveness of the hemostatic agents were total blood loss; hidden blood loss; external blood loss; transfusion rate; intraoperative blood loss; decreases in hemoglobin and hematocrit values; surgical drainage output; visual analogue scale; and surgical complications. There were no significant differences between any of the study variables for the group receiving oral aminocaproic acid and the group receiving oral TXA (p > 0.05), with the exception of patients who received TXA, who presented with more adverse events (p = 0.04). Our study showed that the use of oral aminocaproic acid was similar to its counterpart TXA regarding the evaluated parameters. Although patients who received TXA presented an average of 140 mL less blood loss than patients in the ε-ACA group, the difference did not appear to be clinically important, the transfusion rate was very low, and there were no between-group differences in postoperative complications.

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ε-Aminocaproic Acid (EACA)

Cited by 2 publications

References 46 publications

Cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm

Cathepsin A activity of a parietal thrombus of an abdominal aortic aneurysm

First Comparative Study of the Effectiveness of the Use of Tranexamic Acid against ε-Aminocapróic Acid via the Oral Route for the Reduction of Postoperative Bleeding in TKA: A Clinical Trial

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