ΔNp63α promotes cigarette smoke-induced renal cancer stem cell activity via the Sonic Hedgehog pathway
Yuxiang Zhao,
Nannan Ma,
Wanngyu Wu
et al.
Abstract:Cigarette smoke (CS) has been generally recognized as a chief carcinogenic factor
in renal cell carcinoma (RCC). The stimulative effect of CS on renal cancer stem
cells (RCSCs) has been described previously. The Sonic Hedgehog (SHH) pathway
plays an essential role in self-renewal, cell growth, drug resistance,
metastasis, and recurrence of cancer stem cells (CSCs). Renal cancer-related
gene ΔNp63α is highly expressed in renal epithelial tissues and contributes to
the RCSCs characteristics of tumors. The aim of… Show more
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