Δ9-Tetrahydrocannabinol (Δ9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques

Simon, Liz; Song, Keijing; Stouwe, Curtis Vande; Hollenbach, Andrew D.; Amedee, Angela M.; Mohan, Mahesh; Winsauer, Peter J.; Molina, Patricia E.

doi:10.1007/s11481-015-9645-6

“…We have shown the top TFs and its related diseases for rhesus inter-species in Table 5 . Besides these, mml-miR-338-5p, mml-miR-218, mml-miR-495, mml-miR-203, mml-miR-590-3p, mml-miR-596, mml-miR-548p, and mml-miR-524-5p have connection with “an auto immune disease like SIV” [ 52 ], Huntintong’s Disease [ 53 ], Age mediated skeletal muscle contamination [ 54 ], Enhances Coxsackievirus B3 replication [ 55 ], Neuro inflammation Disorder [ 56 ], Schizophernia [ 57 ], monkey hippocampus effected [ 58 ], and Amyotrophic lateral sclerosis [ 59 ], respectively. Table 6 describes the details information about the relation between the top miRNAs and diseases for rhesus intra-species study.…”

Section: Resultsmentioning

confidence: 99%

“… MiRNAs Number o connected gene-modules Number of targeted genes Name of the connected gene-modules (number of targeted genes in the modules) Disease and Disease-verified information of miRNAs Status of miRNAs 1 mml-miR-338-5p 2 33 Blue (6), Turquoise (27). An auto immune disease like SIV [ 52 ] Known 2 mml-miR-218 2 25 Blue (6), Turquoise (19). Huntintong’s Disease [ 53 ] Known 3 mml-miR-768-3p 2 25 Blue (9), Turquoise (16).…”

Section: Resultsmentioning

confidence: 99%

Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

Maulik

¹

,

Sen

²

,

Mallik

³

et al. 2018

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BackgroundStudy of epigenetics is currently a high-impact research topic. Multi stage methylation is also an area of high-dimensional prospect. In this article, we provide a new study (intra and inter-species study) on brain tissue between human and rhesus on two methylation cytosine variants based data-profiles (viz., 5-hydroxymethylcytosine (5hmC) and 5-methylcytosine (5mC) samples) through TF-miRNA-gene network based module detection.ResultsFirst of all, we determine differentially 5hmC methylated genes for human as well as rhesus for intra-species analysis, and differentially multi-stage methylated genes for inter-species analysis. Thereafter, we utilize weighted topological overlap matrix (TOM) measure and average linkage clustering consecutively on these genesets for intra- and inter-species study.We identify co-methylated and multi-stage co-methylated gene modules by using dynamic tree cut, for intra-and inter-species cases, respectively. Each module is represented by individual color in the dendrogram. Gene Ontology and KEGG pathway based analysis are then performed to identify biological functionalities of the identified modules. Finally, top ten regulator TFs and targeter miRNAs that are associated with the maximum number of gene modules, are determined for both intra-and inter-species analysis.ConclusionsThe novel TFs and miRNAs obtained from the analysis are: MYST3 and ZNF771 as TFs (for human intra-species analysis), BAZ2B, RCOR3 and ATF1 as TFs (for rhesus intra-species analysis), and mml-miR-768-3p and mml-miR-561 as miRs (for rhesus intra-species analysis); and MYST3 and ZNF771 as miRs(for inter-species study). Furthermore, the genes/TFs/miRNAs that are already found to be liable for several brain-related dreadful diseases as well as rare neglected diseases (e.g., wolf Hirschhorn syndrome, Joubarts Syndrome, Huntington’s disease, Simian Immunodeficiency Virus(SIV) mediated enchaphilits, Parkinsons Disease, Bipolar disorder and Schizophenia etc.) are mentioned.Electronic supplementary materialThe online version of this article (doi:10.1186/s12863-017-0574-7) contains supplementary material, which is available to authorized users.

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“…Another very important aspect regarding the impact of CB1 and CB2 receptors on the metabolism is given by the modulating properties of the CB1 on lypogenesis and on the control of the glucose levels. Some studies have shown that through the interaction of CB1 and 2-AG receptors, as well as with AES, one can increase the glucose metabolism, activate mitochondrial biosynthesis, and reduce adiponectin production [54,61,62]. Table 1.…”

Section: The Expression Of Cannabinoid Signaling System In Sepsismentioning

confidence: 99%

Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis

Dinu

¹

,

Rogobete

²

,

Bratu

³

et al. 2020

Cells

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Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levels. The aim of this review paper was to present, in detail, the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, we wish to present the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression.

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“…Biochemical processes for the biosynthesis of microRNAs. microRNA-124 interactions [130][131][132], microRNA-181 interactions [133][134], microRNA-10a interactions [135][136][137], microRNA-21 interactions [138][139][140][141][142], microRNA-92a interactions [142][143], microRNA-125b, microRNA-130a, microRNA-210 [144][145][146][147][148].…”

Section: Micrornas Expression In Sepsis-induced By Cannabinoid Signalmentioning

confidence: 99%

Cannabis Sativa Revisited - Crosstalk between microRNAs Expression, Inflammation, Oxidative Stress and Endocannabinoid Response System in Critically Ill Patients with Sepsis

Rogobete¹,

Bratu²,

Bedreag³

et al. 2019

Preprint

0

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Critically ill patients with sepsis require a multidisciplinary approach, as this situation implies multiorgan distress, with most of the bodily biochemical and cellular systems being affected by the condition. Moreover, sepsis is characterized by a multitude of biochemical interactions and by dynamic changes of the immune system. At the moment, there is a gap in our understanding of the cellular, genetic, and molecular mechanisms involved in sepsis. One of the systems intensely studied in recent years is the endocannabinoid signaling pathway, as light was shed over a series of important interactions of cannabinoid receptors with biochemical pathways, specifically for sepsis. Furthermore, a series of important implications on inflammation and the immune system that are induced by the activity of cannabinoid receptors stimulated by the delta-9-tetrahydrocannabinol (Δ9-THC) and cannabidiol (CBD) have been noticed. One of the most important is their ability to reduce the biosynthesis of pro-inflammatory mediators and the modulation of immune mechanisms. Different studies have reported that cannabinoids can reduce oxidative stress at mitochondrial and cellular levelsThe aim of this review paper was to present, in detail, the important mechanisms modulated by the endocannabinoid signaling pathway, as well as of the molecular and cellular links it has with sepsis. At the same time, we wish to present the possible implications of cannabinoids in the most important biological pathways involved in sepsis, such as inflammation, redox activity, immune system, and epigenetic expression. cascade and in the evolution of sepsis are represented by the inflammatory response, immune response, and redox activity, followed by the involvement of cellular defects, which all lead to severe organ dysfunction. Adding to this phenomenon are severe respiratory infections; tissue hypoxia; acute kidney injury (AKI); metabolic imbalances; and, last but not least, derangements of the biological system as a whole. Through the augmentation of the inflammatory status and through the concomitant derangement of several organ functions, a high percentage of critical patients with sepsis develop multiple organ dysfunction syndrome (MODS), and finally death [8,[10][11][12].Numerous biochemical and cellular systems involved in sepsis pathogenesis have been studied, both in order to better understand these complex mechanisms, and in the hope of finding new therapeutic targets. The endocannabinoid response system is one of them. Recent studies have shown the involvement of specific endocannabinoid receptors, such as endocannabinoid CB1 receptor and CB2 receptor, as well as their link with important processes in sepsis, such as the immune response, inflammatory response, and redox activity [13]. Furthermore, a series of implications on the epigenetic processes have also been proven, through the change in the microRNAs expression, the microRNAs responsible for the modulation of the immune, and inflammatory systems [14]. It was also shown that by stimulatin...

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Δ9-Tetrahydrocannabinol (Δ9-THC) Promotes Neuroimmune-Modulatory MicroRNA Profile in Striatum of Simian Immunodeficiency Virus (SIV)-Infected Macaques

Cited by 21 publications

References 69 publications

Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

Detecting TF-miRNA-gene network based modules for 5hmC and 5mC brain samples: a intra- and inter-species case-study between human and rhesus

Cannabis Sativa Revisited—Crosstalk between microRNA Expression, Inflammation, Oxidative Stress, and Endocannabinoid Response System in Critically Ill Patients with Sepsis

Cannabis Sativa Revisited - Crosstalk between microRNAs Expression, Inflammation, Oxidative Stress and Endocannabinoid Response System in Critically Ill Patients with Sepsis

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