δ-Tocotrienol in Combination with Resveratrol Improves the Cardiometabolic Risk Factors and Biomarkers in Patients with Metabolic Syndrome: A Randomized Controlled Trial

The protective role of resveratrol in diabetic wound healing

“…As for human clinical trials, 16 clinical trials, including 698 subjects, have also confirmed the antihyperglycemia effect of resveratrol from 2008 to 2023. Experimental participants were administrated orally with resveratrol or trans‐resveratrol or resveratrol capsules at a dose of 10 mg−3 g/day for 2–24 weeks, and the levels of their blood glucose were reduced significantly compared with placebo groups (Fatima et al, 2023; Öztürk et al, 2017) (clinical trials can be searched in ClinicalTrials. gov on resveratrol).…”

Targeting ferroptosis: New perspectives of Chinese herbal medicine in the treatment of diabetes and its complications

“…Besides, berberine combined with probiotics significantly reduces postprandial hyperlipidemia and CVD risk in patients with diabetes [ 75 ]. Resveratrol andδ-tocotrienol mixture supplementations improved cardiometabolic risk factors and biomarkers of inflammation and oxidative stress in patients with Metabolic syndrome [ 76 ]. The specific mechanism is not yet very clear.…”

“… A random, placebo-controlled, and multicenter clinical trial Significantly reduce postprandial hyperlipidemia and CVD risk in patients with diabetes. Fatima, Safia et al [ 76 ] δ-tocotrienol and resveratrol mixture Patients with metabolic syndrome (n = 41） 24 weeks A randomized placebo-controlled study Reduce the waist circumference, blood pressure, and FPG. Partial abbreviation: T2DM: type 2 diabetes mellitus; DR: diabetic retinopathy; FG：fasting glucose; 2hPPG: 2-h post-prandial blood glucose; HbA1c: the hemoglobin A1c; TC: total cholesterol; LDL-C: low-density lipoprotein cholesterol; HDL-C: high-density lipoprotein cholesterol; CVD: cardiovascular disease.…”

Comparative efficacy of tocotrienol and tocopherol (vitamin E) on atherosclerotic cardiovascular diseases in humans

“…12 TCTs have been revealed to have better antioxidant capability compared to TCPs. 13 In view of cardiometabolic effects, research has shown the role of TCTs as a supplement with cholesterol-lowering properties. 14 Apart from it, many randomised controlled trials (RCTs) have explored the effect of TCT in patients having dyslipidaemia, and different metabolic disorders, like diabetes mellitus (DM) and non-alcoholic fatty liver disease (NAFLD), reporting a range of effects.…”

“…14 Apart from it, many randomised controlled trials (RCTs) have explored the effect of TCT in patients having dyslipidaemia, and different metabolic disorders, like diabetes mellitus (DM) and non-alcoholic fatty liver disease (NAFLD), reporting a range of effects. 13 In view of dyslipidaemia contributing to ASCVD, and the role of TCPs and TCTs in decreasing serum lipid parameters with varying results, it is necessary to review the available evidence to compare the efficacy of both supplements in the management of CVDs. To the best of our best knowledge, there is no systematic review in literature that has compared the efficacy of TCP and TCT supplements in the management of CVDs.…”