γδT cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface

Uchida, Ryo; Ashihara, Eishi; Satô, Kiyoshi; Kimura, Shinya; Kuroda, Junya; Takeuchi, Miki; Kawata, Eri; Taniguchi, Kyoko; Okamoto, Masashi; Shimura, Kazuho; Kiyono, Yasushi; Shimazaki, Chihiro; Taniwaki, Masafumi; Maekawa, Taira

doi:10.1016/j.bbrc.2007.01.031

Cited by 56 publications

(56 citation statements)

References 19 publications

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“…The cells have antigen recognition properties and effect the regulation of immune response through cell contact dependent mechanism and secretion of cytokines (Uchida et al, 2007). Previous studies have reported that Τ cells cultured from human peripheral blood may be vital in anticancer surveillance (Campillo et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

Quercetin potentiates the effect of γδ T cells via modulating the expressions of Granzyme B, perforin and IFN-γ and also regulates the Wnt/β-catenin signalling pathway in human colon cancer cells

Lu¹,

Peng²,

Hu³

et al. 2015

Bangladesh J Pharmacol

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<p>Cancer accounts as one of the leading causes of morbidity and mortality. Recent studies focus on the efficiency of phytochemicals in cancer therapy. Influence of quercetin, a flavonoid on the effect of γδ T cells and Wnt/β-catenin signalling pathway in human colon cancer cells (HT55 and HCT116) was investigated. Quercetin at 15-120 µM was observed to markedly reduce the viability of HT55 and HCT116 cells. Quercetin exposure significantly increased γδ T cell proliferation and also raised the expressions of granzyme B (Gra B), perforin (PFP), and interferon- γ (IFN-γ) in γδ T cells. Reduced β-catenin expression with increased expressions of phosphorylated- β-catenin, axin1 and 2 were observed in HT55 and HCT116 cells on exposure to quercetin. However β-actin expression was found to be not much altered. The results suggest that quercetin was able to efficiently potentiate the effect of γδ T cells and modulate Wnt/β-catenin signalling pathway.</p><p> </p>

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Section: Discussionmentioning

confidence: 99%

Quercetin potentiates the effect of γδ T cells via modulating the expressions of Granzyme B, perforin and IFN-γ and also regulates the Wnt/β-catenin signalling pathway in human colon cancer cells

Lu¹,

Peng²,

Hu³

et al. 2015

Bangladesh J Pharmacol

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“…If the threshold icer is CA$100,000 per qaly, the estimated probability that zoledronic acid is where sres are typically defined as hypercalcemia, pathologic fracture, spinal cord compression, and radiotherapy to bone 2 . Several bisphosphonates have also demonstrated anticancer activity in preclinical models [3][4][5][6][7][8] . A randomized controlled trial comparing conventional chemotherapy therapy alone with zoledronic acid 4 mg intravenously once every 28 days plus conventional chemotherapy in 94 previously untreated multiple myeloma patients reported a significant benefit on overall survival (os) with the addition of zoledronic acid 9 .…”

Section: Resultsmentioning

confidence: 99%

Cost-Effectiveness of Zoledronic Acid Compared with Clodronate in Multiple Myeloma

et al. 2012

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phd § cost-effective is 80%. Assuming that the benefits of zoledronic acid on pfs and os diminish over 5 years beginning at the end of year 5, the icer is CAN$63,027 per qaly gained. If the benefits of zoledronic acid on pfs and os are assumed to persist for 5 years only, the icer is CAN$76,948 per qaly gained. ConclusionsCompared with clodronate, zoledronic acid represents a cost-effective treatment alternative in patients with multiple myeloma.

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“…Subsequent to these seminal papers, other groups have shown that MM Vc9Vd2 T cells can be induced to recognize and kill myeloma and lymphoma cells upon stimulation with NBPs or s-pAgs such as IPP and BrHPP [6,7,46,48,49]. We have shown that ZA induced the activation and proliferation of peripheral blood Vc9Vd2 T cells via autologous monocytes, which serve as endogenous IPP producers, and by enhancing the immunosensitivity of myeloma cells to Vc9Vd2 T cells.…”

Section: Preclinical Evidences Of Antitumor Vc9vd2 T Cell Activity Inmentioning

confidence: 95%

“…The intracellular cell adhesion molecule-1 (ICAM-1) is another cell surface molecule playing a key role in Vc9Vd2 T cell-mediated myeloma cell recognition and killing [46]. Uchida et al have shown that the susceptibility of RPMI 8226 and U266 myeloma cell lines to the cytotoxic activity of Vc9Vd2 T cells requires both recognition of the Mev pathway metabolites, and expression of ICAM-1.…”

Section: Expression Of Nkg2d Ligands and Other Tcr-independent Targetmentioning

confidence: 99%

Vγ9Vδ2 T cell-based immunotherapy in hematological malignancies: from bench to bedside

Castella

Vitale

Coscia

et al. 2011

Cell. Mol. Life Sci.

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Many hematological malignancies consist of tumor cells that are spontaneously recognized and killed by Vγ9Vδ2 T cells. These tumor cells generate high amounts of intracellular phosphorylated metabolites mimicking the natural ligands and display a wide range of stress-induced self-ligands that are recognized by Vγ9Vδ2 T cells via TCR-dependent and TCR-independent mechanisms. The intrinsic features of Vγ9Vδ2 T cells and that of tumor cells of hematological origin constitute an ideal combination from which to develop Vγ9Vδ2 T cell-based immune interventions. In this review, we will discuss the rationale, preclinical and clinical data in favor of this therapeutic strategy and the future perspectives of its development.

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γδT cells kill myeloma cells by sensing mevalonate metabolites and ICAM-1 molecules on cell surface

Cited by 56 publications

References 19 publications

Quercetin potentiates the effect of γδ T cells via modulating the expressions of Granzyme B, perforin and IFN-γ and also regulates the Wnt/β-catenin signalling pathway in human colon cancer cells

Quercetin potentiates the effect of γδ T cells via modulating the expressions of Granzyme B, perforin and IFN-γ and also regulates the Wnt/β-catenin signalling pathway in human colon cancer cells

Cost-Effectiveness of Zoledronic Acid Compared with Clodronate in Multiple Myeloma

Vγ9Vδ2 T cell-based immunotherapy in hematological malignancies: from bench to bedside

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