γδ T Lymphocytes as a Double-Edged Sword—State of the Art in Gynecological Diseases

Pawłowska, Anna; Natochina, Yelizaveta; Zardzewiały, Witold; Skiba, Wiktoria; Włodarczyk, Karolina; Maciejczyk, Aleksandra; Suszczyk, Dorota; Wertel, Iwona

doi:10.3390/ijms232314797

Cited by 3 publications

(1 citation statement)

References 83 publications

(180 reference statements)

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“…They have been verified to have potent anti-tumor activity, implying their promising usage in clinical treatments for patients with malignant tumors ( 1 , 18 , 19 ). Vδ1 + and Vδ3 + γδT cells, on the other hand, are more common in peripheral tissues ( 20 ). Most Vδ1 + γδT cells are found in the epithelial tissues, for instance, the intestine and the skin.…”

Section: Introductionmentioning

confidence: 99%

γδT cells in oral tissue immune surveillance and pathology

Chen

Du²,

Liu³

et al. 2023

Front. Immunol.

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The oral mucosa’s immune system is composed of tissue-resident and specifically recruited leukocytes that could effectively tolerate a wide range of microbial and mechanical assaults. Shortly after CD4+ helper T cells (TH17 cells) that produce interleukin 17 (IL-17) were identified, it was discovered that γδT cells could also induce substantial levels of this pro-inflammatory cytokine. In the past decades, it has become clear that due to a complicated thymic program of development, γδT cells frequently serve as the primary sources of IL-17 in numerous models of inflammatory diseases while also assisting in the maintenance of tissue homeostasis in the skin and intestine. But it wasn’t until recently that we took thorough insight into the complex features of γδT cells in the oral mucosa. Most gingival intraepithelial γδT cells reside in the junctional epithelium adjacent to the dental biofilm, suggesting their potential role in regulating oral microbiota. However, inconsistent results have been published in this regard. Similarly, recent findings showed contradictory data about the role of γδT lymphocytes in experimental periodontitis based on different models. In addition, conflicting findings were presented in terms of alveolar bone physiology and pathology underlying the oral mucosa. This review provided an overview of current knowledge and viewpoints regarding the complex roles played by oral-resident γδT cells in host-microbiota interactions, gingivitis and periodontitis, bone physiology and pathology.

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Section: Introductionmentioning

confidence: 99%

γδT cells in oral tissue immune surveillance and pathology

Chen

Du²,

Liu³

et al. 2023

Front. Immunol.

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Landscape of unconventional γδ T cell subsets in cancer

Azimnasab-sorkhabi,

Soltani-asl,

Soleiman Ekhtiyari

et al. 2024

Mol Biol Rep

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Identification of STEAP3-based molecular subtype and risk model in ovarian cancer

et al. 2023

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Background Ovarian cancer (OC) is one of the most common malignancies in women. It has a poor prognosis owing to its recurrence and metastasis. Unfortunately, reliable markers for early diagnosis and prognosis of OC are lacking. Our research aimed to investigate the value of the six-transmembrane epithelial antigen of prostate family member 3 (STEAP3) as a prognostic predictor and therapeutic target in OC using bioinformatics analysis. Methods STEAP3 expression and clinical data were acquired from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx), and Gene Expression Omnibus (GEO). Unsupervised clustering was used to identify molecular subtypes. Prognosis, tumor immune microenvironment (TIME), stemness indexes, and functional enrichment analysis were compared between two definite clusters. Through the least absolute shrinkage and selection operator (LASSO) regression analysis, a STEAP3-based risk model was developed, and the predictive effectiveness of this signature was confirmed using GEO datasets. A nomogram was used to predict the survival possibility of patients. Additionally, TIME, tumor immune dysfunction and exclusion (TIDE), stemness indexes, somatic mutations, and drug sensitivity were evaluated in different risk groups with OC. STEAP3 protein expression was detected using immunohistochemistry (IHC). Results STEAP3 displayed marked overexpression in OC. STEAP3 is an independent risk factor for OC. Based on the mRNA levels of STEAP3-related genes (SRGs), two distinct clusters were identified. Patients in the cluster 2 (C2) subgroup had a considerably worse prognosis, higher immune cell infiltration, and lower stemness scores. Pathways involved in tumorigenesis and immunity were highly enriched in the C2 subgroup. A prognostic model based on 13 SRGs was further developed. Kaplan-Meier analysis indicated that the overall survival (OS) of high-risk patients was poor. The risk score was significantly associated with TIME, TIDE, stemness indexes, tumor mutation burden (TMB), immunotherapy response, and drug sensitivity. Finally, IHC revealed that STEAP3 protein expression was noticeably elevated in OC, and overexpression of STEAP3 predicted poor OS and relapse-free survival (RFS) of patients. Conclusion In summary, this study revealed that STEAP3 reliably predicts patient prognosis and provides novel ideas for OC immunotherapy.

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γδ T Lymphocytes as a Double-Edged Sword—State of the Art in Gynecological Diseases

Cited by 3 publications

References 83 publications

γδT cells in oral tissue immune surveillance and pathology

γδT cells in oral tissue immune surveillance and pathology

Landscape of unconventional γδ T cell subsets in cancer

Identification of STEAP3-based molecular subtype and risk model in ovarian cancer

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