γδ T cells present antigen to CD4+ αβ T cells

Collins, Robert A.; Werling, Dirk; Duggan, Sara E.; Bland, A. P.; Parsons, K.R.; Howard, Christopher

doi:10.1002/jlb.63.6.707

Cited by 94 publications

(69 citation statements)

References 30 publications

(52 reference statements)

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“…Positioning in peripheral blood and immediate responsiveness to inflammatory cues ensure their rapid, innate-like involvement in host defense. ␥␦ T-APCs not only mobilize proinflammatory (IFN-␥, TNF-␣, chemokines) and cytotoxic activities (4-6) but also process microbial antigen for induction of CD8 ϩ (as evidenced here) and CD4 ϩ ␣␤ T cell responses (10)(11)(12)(13). This model portrays ␥␦ T cells as forming a vital part in the first-line defense in response to microbial challenges or tumors and emphasizes their exceptional ability to bridge innate and adaptive immunity.…”

Section: Discussionmentioning

confidence: 75%

See 1 more Smart Citation

Cross-presenting human γδ T cells induce robust CD8 ⁺ αβ T cell responses

Brandes

Willimann

Bioley

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

223

229

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Section: Discussionmentioning

confidence: 75%

“…Of note, antigen-presenting ␥␦ T cells have also been reported in cows (11); pigs (12); and, most recently, mice (13). Reactivity to HMB-PP-expressing microbes and certain tumors suggested to us a role for human ␥␦ T-APCs in the induction of pathogen/tumor-specific CD8 ϩ T effector cells.…”

mentioning

confidence: 94%

Cross-presenting human γδ T cells induce robust CD8 ⁺ αβ T cell responses

Brandes

Willimann

Bioley

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

223

229

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show abstract

“…␥␦ T cells react directly with unprocessed Ag (62) and mediate effector functions including cytokine production, cytotoxicity, and presentation of Ag to ␣␤ T cells (63)(64)(65). Pulmonary ␥␦ T cells comprise a heterogeneous population that are found both in normal mice and in a variety of infectious models (66 -68).…”

Section: Figurementioning

confidence: 99%

Subset-Specific Reductions in Lung Lymphocyte Accumulation Following Intratracheal Antigen Challenge in Endothelial Selectin-Deficient Mice

Curtis

Sonstein²,

Craig

et al. 2002

The Journal of Immunology

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We previously demonstrated induction and expression of CD62E and CD62P in the lungs of mice primed and then challenged with intratracheal (i.t.) SRBC. The current study examined accumulation of endogenous lymphocytes in the lungs of endothelial E- and P-selectin-deficient (E−P−) mice after i.t. SRBC challenge. Compared with syngeneic wild-type (wt) mice, E−P− mice showed an 85–95% decrease in CD8+ T cells and B cells in the lungs at both early and late time points. In contrast, CD4+ T cell accumulation was reduced by ∼60% early, but equivalent to wt levels later. Surprisingly, many γδ T cells were found in lungs and blood of E−P− mice but were undetectable in the lungs and blood of wt mice. Absolute numbers of peripheral blood CD4, CD8, and B lymphocytes in E−P− mice equaled or exceeded the levels in wt mice, particularly after challenge. Trafficking studies using αβ T lymphoblasts confirmed that the recruitment of circulating cells after challenge was markedly reduced in E−P− mice. Furthermore, Ag priming occurred normally in both the selectin-deficient and wt mice, because primed lymphocytes from both groups transferred Ag sensitivity into naive wt mice. Lung production of mRNA for six CC and two CXC chemokines after challenge was equivalent by RT-PCR analysis in wt and E−P− mice. Therefore, reduced lung accumulation of αβ T cells and B cells in E−P− mice did not result from reduced delivery of circulating lymphocytes to the lungs, unsuccessful Ag priming, or defective pulmonary chemokine production. Selectin-dependent lymphocyte recruitment into the lungs following i.t.-SRBC challenge is subset specific and time dependent.

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“…5). It is also known that cultured WC1 ϩ ␥␦ T cells can act as APCs for ␣␤ T cells (33). In contrast, WC1…”

Section: Discussionmentioning

confidence: 99%

Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H3

Nagai

Aso

Ogasawara

et al. 2008

The Journal of Immunology

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Stem/Progenitor cells in the postnatal pituitary gland are embedded in a marginal cell layer around Rathke’s pouch. However, the nature and behavior of anterior pituitary progenitor cells remain unclear. We established bovine anterior pituitary progenitor cell line (BAPC)-1 from the anterior pituitary gland, which expressed stem/progenitor cell-related genes and several inflammatory cytokines. To characterize and localize these pituitary progenitor cells, we produced a mAb (12B mAb) against BAPC-1. The 12B mAb recognized the 4Ig-B7-H3 molecule, which is a costimulatory molecule and negative regulator in T cell activation. WC1+ γδ T cells in young bovine PBMC express the 4Ig-B7-H3 molecule, but few or no 4Ig-B7-H3-immunoreactive cells are expressed in PBMC in adult cattle. The 12B-immunoreactive cells in the bovine anterior pituitary gland were localized around Rathke’s pouch and expressed IL-18 and MHC class II. However, the number of 12B-immunoreactive cells was lower in adult than in young cattle. BAPC-1 expressed IL-18 and MHC class II, and demonstrated phagocytotic activity. BAPC-1 also had the ability to promote CD25 expression in PBMC after 5 days of coculture, and blocking 4Ig-B7-H3 × 12B mAb enhanced their expression of CD25. In addition, the 12B-immunoreactive cells were observed around the pars tuberalis closely bordering the median eminence and in the blood vessels of the primary portal plexus in the anterior pituitary gland. These results suggest that an established BAPC-1 may originate from these progenitor cells, and that the progenitor cells with 4Ig-B7-H3 may play a critical role in the immunoendocrine network.

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γδ T cells present antigen to CD4+ αβ T cells

Cited by 94 publications

References 30 publications

Cross-presenting human γδ T cells induce robust CD8 ⁺ αβ T cell responses

Cross-presenting human γδ T cells induce robust CD8 ⁺ αβ T cell responses

Subset-Specific Reductions in Lung Lymphocyte Accumulation Following Intratracheal Antigen Challenge in Endothelial Selectin-Deficient Mice

Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H3

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γδ T cells present antigen to CD4+ αβ T cells

Cited by 94 publications

References 30 publications

Cross-presenting human γδ T cells induce robust CD8 + αβ T cell responses

Cross-presenting human γδ T cells induce robust CD8 + αβ T cell responses

Subset-Specific Reductions in Lung Lymphocyte Accumulation Following Intratracheal Antigen Challenge in Endothelial Selectin-Deficient Mice

Anterior Pituitary Progenitor Cells Express Costimulatory Molecule 4Ig-B7-H3

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Cross-presenting human γδ T cells induce robust CD8 ⁺ αβ T cell responses

Cross-presenting human γδ T cells induce robust CD8 ⁺ αβ T cell responses