γδ T cells and the PD-1/PD-L1 axis: a love–hate relationship in the tumor microenvironment
Jian Liu,
Min Wu,
Yifan Yang
et al.
Abstract:Gamma delta (γδ) T cells demonstrate strong cytotoxicity against diverse cancer cell types in an MHC-independent manner, rendering them promising contenders for cancer therapy. Although amplification and adoptive transfer of γδ T cells are being evaluated in the clinic, their therapeutic efficacy remains unsatisfactory, primarily due to the influence of the immunosuppressive tumor microenvironment (TME). Currently, the utilization of targeted therapeutic antibodies against inhibitory immune checkpoint (ICP) mo… Show more
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