γδ T‐Cell Subset Distribution in Human Semen From Fertile Donors

Bertotto, A; Spinozzi, Fabrizio; Gerli, Roberto; Bassotti, Gabrio; Fabietti, G.; Castellucci, G; Vagliasindi, C; Vaccaro, R

doi:10.1111/j.1600-0897.1995.tb00935.x

Cited by 6 publications

(4 citation statements)

References 4 publications

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“…The predominant TCR␥␦ ϩ cell subset in the thymus is the V␦1 ϩ T cell subset, which is also the dominant in the spleen and the major T cell population in the intestinal epithelia (15). Furthermore, V␦1 ϩ TCR␥␦ ϩ cells are reported in other peripheral sites such as the nasal mucosa (62), oral epithelia (63), lungs (64), semen (65), and decidua of the placenta during pregnancy (66). Localization of V␦1 TCR␥␦ ϩ cells in some of these peripheral sites is thought to be by a integrin-mediated extravasation capability unique to V␦1 ϩ T cells (67).…”

Section: Discussionmentioning

confidence: 99%

TCRγδ+ and CD161+ Thymocytes Express HIV-1 in the SCID-hu Mouse, Potentially Contributing to Immune Dysfunction in HIV Infection

Gurney

Yang

Wilson

et al. 2002

The Journal of Immunology

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The vast diversity of the T cell repertoire renders the adaptive immune response capable of recognizing a broad spectrum of potential antigenic peptides. However, certain T cell rearrangements are conserved for recognition of specific pathogens, as is the case for TCRγδ cells. In addition, an immunoregulatory class of T cells expressing the NK receptor protein 1A (CD161) responds to nonpeptide Ags presented on the MHC-like CD1d molecule. The effect of HIV-1 infection on these specialized T cells in the thymus was studied using the SCID-hu mouse model. We were able to identify CD161-expressing CD3+ cells but not the CD1d-restricted invariant Vα24/Vβ11/CD161+ NK T cells in the thymus. A subset of TCRγδ cells and CD161-expressing thymocytes express CD4, CXCR4, and CCR5 during development in the thymus and are susceptible to HIV-1 infection. TCRγδ thymocytes were productively infectable by both X4 and R5 virus, and thymic HIV-1 infection induced depletion of CD4+ TCRγδ cells. Similarly, CD4+CD161+ thymocytes were depleted by thymic HIV-1 infection, leading to enrichment of CD4−CD161+ thymocytes. Furthermore, compared with the general CD4-negative thymocyte population, CD4−CD161+ NK T thymocytes exhibited as much as a 27-fold lower frequency of virus-expressing cells. We conclude that HIV-1 infection and/or disruption of cells important in both innate and acquired immunity may contribute to the overall immune dysfunction seen in HIV-1 disease.

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Section: Discussionmentioning

confidence: 99%

TCRγδ+ and CD161+ Thymocytes Express HIV-1 in the SCID-hu Mouse, Potentially Contributing to Immune Dysfunction in HIV Infection

Gurney

Yang

Wilson

et al. 2002

The Journal of Immunology

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“…[21] showed that ASAs are associated with increased numbers of both γδ and cytotoxic T cells in seminal fluid of males with unexplained infertility especially with chlamydia trachomatis infections. Bertotto et al [22] carried out direct immunofluorescence staining following two colour cytoflorometric analysis on mononuclear cells (MCs) suspensions from ejaculates of 10 healthy fertile volunteers to study the γδ T cell subset distribution in normal human serum. Autologous peripheral blood MC were also simultaneously analysed and results were used for statistical comparison.…”

Section: Role Of T Cellsmentioning

confidence: 99%

“…This was in contrast with their normal blood picture where most γδ T cells express Vδ 2 conformational epitope. Hence, Bertotto et al [22] concluded that there is a numerical as well as phenotypical difference in semen γδ T lymphocyte which provides evidence of a migratory lymphocyte subset balance in anatomically and physiologically distinct areas of body. They further suggested that their functional role in terms of both helper and suppressor cytotoxic activities in the non- sterile proximal portion of the male genital tract needs to be explored.…”

Section: Role Of T Cellsmentioning

confidence: 99%

An update on Immunologic Infertility-special Emphasis on Role of PD-1(Programmed Death 1) Gene

Kaur¹

2014

JFIV Reprod Med Genet

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The association of antisperm antibodies and autoimmunity or presence of gamma delta T cells in semen associated with men with ASA related infertility has been recognized as early as the early 90's with specific correlation with antiphospholipid antibodies but it has been concluded in a review in 2002 by Mclachlan RI 2002 that since IUI/ICSI is the final answer there is no point in bothering about looking or investigating for antisperm antibodies and hence not much interest was given till recently interest got rekindled by the appearance of a report on the presence of programed death 1(PD-1) gene polymorphisms in men with ASA related infertility as PD-1 is a negative costimulatory molecule also found in sertoli cells and associated with the transplantation potential or helping in the immune privileged site of testis as reported by Dal secco and hence this review is done to highlight the implications of getting insight into the reason for male immune infertility and its difference from female one and correlation with other autoimmune disorders and future therapeutic potentials including in recurrent mishaps as well as for future orthotopic testicular transplantation in men with testis in inguinal region other causes of immune infertility as simple as just subtle chlamydia infection.

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“…Moreover, the presence of ASAs was associated with increased numbers of both γδ and cytotoxic T cells in seminal fluid of male with unexplained infertility [5]. Traces of αβ-and γδ T cell subsets and antisperm antibodies might be detectible in semen of fertile men in some cases [6,7] The presence of antigen specific T cells in semen fluid suggest their implication in the development of local inflammation and development of auto-antibodies. As normally that the peripheral tolerance pathways locally implicate in protection against auto-reactive responses.…”

Section: Introductionmentioning

confidence: 99%

Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men

Zamani

Asbagh

Massoud

et al. 2014

J Assist Reprod Genet

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Objective Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signalling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. This study investigates PD-1 gene polymorphism in patients with antisperm antibodyrelated infertility Methods Genotyping was performed by polymerase chain reaction and restriction enzyme digestion (PCR-RFLP), this polymorphism was genotyped in 145 Iranian subjects (61 patients with antisperm antibody-related infertility and 84 healthy controls). Results Patients frequencies of the G/A genotype in comparison with healthy controls (38.2 % vs. 32.7 %, OR =1.21, P=0.35) were not significantly different. However, G/G and A/A genotype frequencies between patients and healthy controls were significantly different (P=0.042, P=0.00001, respectively). Also, allele frequencies of this polymorphism were significantly different (P=0.0012) in patients compared to healthy controls. Conclusion According to these results, there is a correlation between PD-1 gene polymorphism and susceptibility to antisperm antibody-related infertility in our study group.

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γδ T‐Cell Subset Distribution in Human Semen From Fertile Donors

Cited by 6 publications

References 4 publications

TCRγδ+ and CD161+ Thymocytes Express HIV-1 in the SCID-hu Mouse, Potentially Contributing to Immune Dysfunction in HIV Infection

TCRγδ+ and CD161+ Thymocytes Express HIV-1 in the SCID-hu Mouse, Potentially Contributing to Immune Dysfunction in HIV Infection

An update on Immunologic Infertility-special Emphasis on Role of PD-1(Programmed Death 1) Gene

Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men

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