γδ T‐cell lymphoma in a cow

Sato, Koya; Shibahara, Tomoyuki; Kadota, Koichi

doi:10.1111/j.1751-0813.2002.tb11307.x

Cited by 12 publications

(23 citation statements)

References 8 publications

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“…Likewise, their malignant counterparts (cases 6 and 9) showed considerably similar cytomorphology, though the cells in case 9 had more widespread cytoplasm. Although it is difficult to distinguish between the neoplastic cells in case 9 and in ordinary cutaneous lymphomas with regression of cutaneous lesions 4 , marked neoplastic invasion of hair follicles is a feature of γδ T cell lymphomas with cutaneous involvement 6,11 . There was neither CD3 nor CD79a expression in case 10.…”

Section: Fig 8 Case 8 Subiliac Lymph Nodementioning

confidence: 99%

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Murayama

Sato

Ikehata

et al. 2011

JARQ

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Ten cases of bovine lymphohematopoietic neoplasms were investigated histologically, histochemically, and immunohistochemically, and were classified into eight histologic types on the basis of the origin and morphology of tumor cells. Case 1, a precursor B lymphoblastic leukemia, was positive for CD79a and terminal deoxynucleotidyl transferase. Case 2, a thymic B cell lymphoma, was also positive for these markers, but there were cytologic differences between the two cases. Cases 3-5 were diagnosed as pleomorphic B cell lymphomas, which were characterized by cytologic pleomorphism and expression of CD79a and CD5, and were etiologically associated with bovine leukosis virus (BLV). A case of diffuse large B cell lymphoma of the cerebrum (case 6) also showed a positive result for CD79a and CD5. However, the lymphoma was composed of a homogeneous population of large neoplastic cells, and was considered to be unrelated to BLV. The other B cell cases were categorized into immunoblastic (case 7) and lymphoplasmacytic (case 8) lymphomas, in which immunoglobulin-producing lymphoma cells were observed. In a cutaneous γδ T cell lymphoma (case 9), the neoplastic cells cytologically resembled those in case 6, but expressed CD3 and WC1. In case 10, an acute basophilic leukemia, some leukemia cells had intracytoplasmic granules that were metachromatic and tryptase positive but negative for naphthol AS-D chloroacetate esterase. Bovine lymphohematopoietic malignancies are classifiable into discrete histologic types according to immunophenotype. The classification is more scientific than the traditional one, the latter being based on the age of affected animals and/or the site of tumor formation.

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Section: Fig 8 Case 8 Subiliac Lymph Nodementioning

confidence: 99%

Cytologic and Immunophenotypic Investigation of Lymphohematopoietic Neoplasms in Cattle

Murayama

Sato

Ikehata

et al. 2011

JARQ

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“…The majority of bovine WC1-positive γδ T cell lymphomas affect the skin or mucous membranes, and show epitheliotropism 7,10,11 . This corresponds to the fact that WC1-positive γδ T cells are found in high numbers in the tissues and seem to defend the body surfaces 5,13 .…”

Section: Discussionmentioning

confidence: 99%

“…γδ T cell lymphomas were found in BLV-negative cattle, and could be classified into several histologic subtypes 7,11 . Although adult-form lymphoma is generalized in tissue distribution 12,14 , γδ T cell lymphoma has a tendency to affect the skin and mucous membranes 7,10,11 . In this paper, we describe two cases of lymphoma of innatelike lymphocyte origin (B-1 B cell lymphoma and γδ T cell lymphoma) that were thought to have arisen from the abdominal cavity.…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Study of Lymphomas of Abdominal Cavity Origin in Two Cows with Bovine Leukemia Virus

Abe

Shoji²,

K³

et al. 2007

JARQ

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Lymphoid neoplasms of abdominal cavity origin were found in two cows infected with bovine leukemia virus (BLV). Case 1 was a 3-year-old Japanese Black cow affected with a B-1 B cell lymphoma. Case 2 was a 14-year-old Japanese Black cow that developed a γδ T cell lymphoma. Immunohistochemically, CD79a-positive lymphoma cells were observed in case 1, whereas CD3-, WC1-or perforin-positive ones were seen in case 2. Despite the expression of CD5 in both lymphomas, the reactivity was surface or cytoplasmic in case 1 and surface membrane in case 2. Erythrophagia by tumor cells of both cases was considered to be due to the fact that their normal counterparts were more primitive forms than conventional lymphocytes.Discipline: Animal health Additional key words: B-1 B cell, CD5, γδ T cell JARQ 41 (2), 153 -156 (2007)

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“…The former includes at least 2 types of epidermotropic T cell lymphoma: CD4-or CD8-positive lymphoma resembling mycosis fungoides and WC1-positive γδ T cell lyphoma 3,5,6,9 . The B cell type, which is presumably nonepidermotropic, is a rare disease of young animals unrelated to bovine leukemia virus (BLV) 7 .…”

Section: Introductionmentioning

confidence: 99%