γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells

In Vitro Anticancer Activities of Anogeissus latifolia, Terminalia bellerica, Acacia catechu and Moringa oleiferna Indian Plants

“…Indeed, G2/M arrest is typically associated with DNA damage and affords the cell time to repair before proceeding with mitosis, thereby preventing the persistence of genomic mutations (Stark and Taylor, 2004). Similar results obtained by Sundarraj et al (2012) who reported that Acacia nilotica extract and γ-Sitosterol were inhibited the cell proliferation in human breast MCF-7 and lung A549 cancer cells by blocking G2/M phase. It is noteworthy that, the absence of G2/M accumulation reported in the present study implied that the damage induced by these extracts are minimal or absent at least in the experimental condition.…”

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“…The anticancer activity of this plant was studied by using various models by several authors. Gamma-sitosterol of A. nilotica exhibited potential anticancer activity through the growth inhibition, cell cycle arrest and the apoptosis on MCF-7 and A549 cells 5 . The aerial parts of methanolic extract of Acacia nilotica have anticancer activity against Dalton's ascetic lymphoma induced solid and ascetic tumor model 6 .…”

Isolation and Identification of gamma-sitosterol by GC-MS from Roots of Girardinia heterophylla

“…Docking studies of the ligand γ-sitosterol with four different target proteins showed that this is a good molecule which docks well with various targets related to Diabetes mellitus, thus γ-sitosterol can be considered for developing into a protein antidiabetic drug 3 . It has been also reported that γ-sitosterol may affect the amount and activity of components of the extrinsic apoptic pathway in human lung and breast adenocarcinoma cells 4 . Present, investigation, provides an avenue for taking up future research and development activities for strengthening the existing pharmacological sciences besides, refining and utilizing traditional knowledge for the welfare of the society.…”