γ-Radiation induced L-glutamic acid grafted highly porous, pH-responsive chitosan hydrogel beads: A smart and biocompatible vehicle for controlled anti-cancer drug delivery

NiIINPs entrapped within a matrix ofl-glutamic acid cross-linked chitosan supported on magnetic carboxylic acid-functionalized multi-walled carbon nanotube: a new and efficient multi-task catalytic system for the green one-pot synthesis of diverse heterocyclic frameworks

“…In the first step, a weight loss (1%) occurred below 240 °C is related to the solvents and moisture evaporations. In the second step, a weight loss (9%) is observed at temperature ranging from 240 °C to 352 °C, which is mainly associated to the decomposition of l -glutamic acid 27 (as the cross-linker) and also is corresponding to the dehydration and depolymerization of the chitosan biopolymer. 28 In the third stage, a weight loss (6%) is observed between temperature range of 352 °C to 542 °C attributed to the complete decomposition of the chitosan structure by degasification of compounds, including NH 3 , CO, CO 2 , and CH 4 .…”

Multiple Roles of Chitosan in Mucosal Drug Delivery: An Updated Review

“…CS hydrogel beads, obtained by ionotropic-gelation and/or PEC formation with negatively charged polymers, demonstrated their ability to retain their content in an acidic environment and to release it in slightly alkaline conditions [ 98 , 298 , 299 , 300 , 301 ]. CS beads realized by ionic crosslinking with phytic acid, proposed for insulin oral delivery, were able to provide a long-lasting hypoglycemic effect after oral administration in diabetic rats [ 302 ].…”

Century Impact of Macromolecules for Advances of Sensing Sciences

“…In an example, the biocompatible chitosan-based beads were prepared after gama radiation-induced copolymerization with the porous, high swelling index of 426% and pH-responsive nature. The hydrogel beads were explored for effective localized delivery of Doxorubicin an anticancer agent under a controlled manner by 81.33% for localized cancer therapy [ 92 ]. This concept of curing specified organs for the particular problem is referred to as the point of care concept for several advanced applications in biomedical science like drug delivery, organ transplants, and tissue engineering.…”