γ-glutamyltransferase dependent generation of reactive oxygen species from a glutathione/transferrin system

Drożdż, Ryszard; Parmentier, C; Hachad, Houda; Leroy, Pierre; Siest, Gérard; Wellman, Maria

doi:10.1016/s0891-5849(98)00127-0

Cited by 148 publications

(106 citation statements)

References 30 publications

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“…Alternatively, we are interested in the possibility that body iron storage plays a role in this interaction between GGT and age, because the cellular role of GGT differs depending on iron storage. [8][9][10][11] In this study, among young subjects who probably had low body iron storage, 18 GGT showed no relationship with hypertension, whereas among old age subjects who probably had high body iron storage, 18 GGT was a strong risk factor for hypertension.…”

Section: Discussioncontrasting

confidence: 47%

“…GGT is a key enzyme for transport of glutathione into cells. Furthermore, recent experimental studies [8][9][10][11] indicated that under physiological conditions, especially in the presence of iron, GGT is involved directly in reactive oxygen species generation as a pro-oxidant. Thus, it may be that GGT plays an antioxidant or pro-oxidant role, depending on the presence of iron or similar oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

“…[5][6][7] Paradoxically, recent studies [8][9][10][11] have shown that GGT is itself able to play a pro-oxidant role, particularly in the presence of iron.…”

Section: Introductionmentioning

confidence: 99%

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Gamma-glutamyltransferase: an effect modifier in the association between age and hypertension in a 4-year follow-up study

Mh²,

et al. 2004

J Hum Hypertens

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We performed a prospective study to assess whether the relationship of age with hypertension was stronger in men with high normal serum gamma glutamyltransferase (GGT) than in those with lower GGT levels. The study population included 8170 healthy male workers in a steel manufacturing company who had undergone health examinations in both 1994 and 1998. The higher the baseline GGT level, the effect of age on the development of hypertension was stronger. The incidence of hypertension among those aged 25-34, 35-44 and 45-50 years was 0.9, 2.2, 3.8% in those with GGTo20 U/l; 1.0, 4.1, 12.5% in those with GGT between 20 and 39 U/l; and 1.9, 6.3, 17.2% in those with GGTX40 U/l, respectively. All relationships persisted after adjusting for baseline values of body mass index, alcohol intake, smoking, exercise, family history of hypertension, systolic and diastolic blood pressure, and changes of body mass index during 4 years (P for interaction ¼ 0.03). Our data supported the hypothesis that the effect of age on the development of hypertension differed by baseline GGT level, although the underlying mechanism for this interaction is unclear.

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Section: Discussioncontrasting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

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Gamma-glutamyltransferase: an effect modifier in the association between age and hypertension in a 4-year follow-up study

Mh²,

et al. 2004

J Hum Hypertens

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“…that GGT enzyme induction may be associated with the generation of reactive oxygen species (ROS) (Holt and Ju, 2010). Also isotretinoin similar to xenobiotic and others drugs may lead to an increase in risk of liver problems (Holt and Ju, 2010;Drozdz et al, 1998). It is observed in patients with acne vulgaris, the incidence of laboratory abnormalities that occurred after management with oral isotretinoin.…”

Section: Discussionmentioning

confidence: 99%

Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

Ahmadv¹

2011

Afr. J. Pharm. Pharmacol.

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The aim of the present study was the evaluation of serum level of lipids and gamma glutamyl transpeptidase (GGT) activities in patients with acne vulgaris undergoing isotretinoin treatment. Fortyfour patients, with severe acne or moderate acne (age mean 23 6±6.0 year) who were resistant to conventional treatment were supplemented with 0.5 mg/kg/day of oral isotretinoin for 120 days. This study revealed a significant increase in serum level of cholesterol, triglyceride and GGT activity. The findings of this work showed a number of negative effects of isotretinoin on disturbances in lipid profile and antioxidant status, in acne patients. Therefore, to control abnormalities in lipid profiles and oxidative stress, we recommend further studies to use antioxidant such as vitamin E supplementation in patients using isotertinoin.

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“…From previous studies, it seems that GGT plays a contradictory role inside and outside the cells (19,20). GGT causes Glutathione degradation and removal of gammaglutamyl portion outside of the cells and released materials are transported into the cells and is used to produce glutathione in the cells.…”

Section: Disscussionmentioning

confidence: 99%

Evaluation of Serum Gamma Glutamyl Transferase Levels in Diabetic Patients With and Without Retinopathy

et al. 2018

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Background: Gamma glutamyl transferase (GGT) is a liver enzyme that is involved in oxidative stress. The association between GGT levels and diabetes complications such as microalbuminuria, retinopathy, and peripheral polyneuropathy is a challenging subject. Objectives: In this study we compared GGT levels in orally treated DM type 2 patients with and without retinopathy. Methods: In this cross-sectional study that was done between the years of 2011 and 2012, 208 patients with Type 2 DM, aged 30 -86 years old, who had received oral agents, and referred to the Endocrine clinic of Emam Khomeini hospital of Urmia city were enrolled. In all patients blood pressure, body mass index, and biochemical tests including fasting blood sugar (FBS) and GGT levels were measured and an ophthalmologic exam was done. Results: From 208 patients with Type 2 DM, 26 subjects (12.5%) had diabetic retinopathy; however, 182 subjects (87.5%) did not have it. Both systolic and diastolic blood pressures were significantly higher in DM 2 patients with retinopathy than those without retinopathy (P values = 0.003 and 0.022, respectively). The mean of GGT level significantly increased in diabetic patients with retinopathy compared those DM 2 patients who did not have retinopathy (P value < 0.001). Prevalence of GGT levels greater than 45 U/l was 61.5% (n = 16) and 10.4% (n = 19) in diabetic patients with and without retinopathy, respectively (P value < 0.001). Conclusions:We suggest that diabetic retinopathy might have an association with higher GGT levels.

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γ-glutamyltransferase dependent generation of reactive oxygen species from a glutathione/transferrin system

Cited by 148 publications

References 30 publications

Gamma-glutamyltransferase: an effect modifier in the association between age and hypertension in a 4-year follow-up study

Gamma-glutamyltransferase: an effect modifier in the association between age and hypertension in a 4-year follow-up study

Effects of oral isotretinoin on serum lipids and gamma glutamyl transpeptidase activity in acne vulgaris patients

Evaluation of Serum Gamma Glutamyl Transferase Levels in Diabetic Patients With and Without Retinopathy

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