γ-Glutamyl transferase and breast cancer risk

Fentiman, IS; Allen, D. S.

doi:10.1038/sj.bjc.6605719

Cited by 47 publications

(32 citation statements)

References 20 publications

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“…A study by Jarari et al [13] reported significantly higher level of serum GGT in breast cancer cases as compared to controls, but the significant hike was observed in the premenopausal group when compared with that of post menopausal similar to our findings. In contrast to our study, increased GGT level was observed in postmenopausal breast cancer patients as compared to premenopausal age group [17,21]. Serum GGT level when compared with patients having different stages of BC, we found proportional increased GGT level from stage I to stage IV and the finding was similar to the study by Chandrakanth et al [16].…”

Section: Resultscontrasting

confidence: 56%

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Basnyat¹,

Jha²,

Pathak³

et al. 2017

JTLS

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Breast cancer (BC) is the most common type of cancer worldwide, being one of the leading causes of morbidity in the female. In Nepal, it is the second most common type of cancer among women of perimenopausal age group. More than one-quarter of the BC is diagnosed in young Nepalese female, with a familial history of breast cancer, early pregnancy, longer lactation and estrogen exposure, often tumors showing aggressive biological behaviors. Anthracyclines (Doxorubicin) based treatment regime were reported to cause cardiotoxicity by increasing intramyocardial free radical production, lipid alterations and decreasing antioxidant level. Oxidative stress involving cellular reactive oxygen species (ROS) production is widely accepted mechanism, but the molecular basis of chemotherapyinduced organ toxicity remains highly controversial. An increased rate of metabolism and oxidative stress results in rapid turnover of cancer cells that modulates the enzyme level in blood circulation. Serum LDH and GGT level correlate with tumor burden, the metastatic character of BC and intensity of organtoxicity. The aim of our study is to evaluate the serum level of LDH and GGT in BC patients receiving chemotherapy and correlate these enzyme levels with different stages of BC. A total number of 150 subjects were included in the study, comprising 90 histopathologically confirmed 24 to 76 years aged patients of different breast cancer stages, receiving at least 3 cycles of 5-Fluorouracil, Adriamycin, and Cyclophosphamide (FAC) chemotherapy. Sixty age-matched healthy women were enrolled as controls. Blood samples from each were collected after informed consent and analyzed for serum LDH and GGT levels using standard biochemical methods. Data were analyzed using student's paired-T test, Pearson correlation test and ANOVA. Serum LDH and GGT levels were significantly (p < 0.001) increased in BC patients as compared to control group. When all 4 stages of BC were compared to control group, LDH and GGT activities showed a progressive increase from stage I to IV. The study concludes that serum LDH and GGT may be sensitive, specific and profitable biomarkers in early diagnosis of breast cancer, assessing cancer prognosis and response to treatment.

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Section: Resultscontrasting

confidence: 56%

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Basnyat¹,

Jha²,

Pathak³

et al. 2017

JTLS

View full text Add to dashboard Cite

show abstract

“…In addition, for the fi rst time in a large population-based cohort a significant association between high GGT levels and increased cancer risk in women was shown. Th is is in accordance with recent research on breast cancer risk [35]. In addition, the fi ndings from VHM&PP further suggest GGT to be involved in the progression of premalignant cervical lesions to invasive cancer.…”

Section: Resultssupporting

confidence: 88%

Associations of serum uric acid and gamma-glutamyltransferase with cancer in the Vorarlberg Health Monitoring and Promotion Programme (VHM&PP) – a short review

Edlinger

Nagel²,

Hilbe

et al. 2011

memo

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Th e Vorarlberg Health Monitoring and Promotion Programme (VHM&PP), based on prospectively gathered, repeated routine health examination data from a cohort of more than 175,000 adults, is one of the largest ongoing population-based risk factor surveillance programmes worldwide. Among others, the so far widely unknown associations of serum uric acid (SUA) and gamma-glutamyltransferase (GGT) with cancer were investigated. Both SUA and GGT are known to be related to the metabolic syndrome and furthermore considered as markers of oxidative stress. After controlling for several confounding factors, it was found that elevated SUA levels were statistically signifi cantly related to overall cancer mortality and several site-specifi c malignancies in both men and women. Additionally, a J-shaped eff ect of SUA levels on risk of overall cancer incidence appeared in men, with signifi cantly increased cancer risk at high levels of SUA. Likewise, in accordance with some experimental evidence, among men and women elevated GGT increased cancer risk overall and for several lifestyle-related malignancies. On the basis of these fi ndings, and considering the routine measurement in clinical practice, SUA and GGT might function as a valuable marker to identify patients with an increased risk to develop malignant diseases.

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“…In the present investigation, the γ-GT activity was found to be increased in cancerbearing animals. This is well in accordance with the previous finding of Makpol et al, and Fentiman and Allen [54,55].…”

Section: Elumalai Et Alsupporting

confidence: 83%

Anticancer Effect of Methanolic Extract of Annona Squamosa on Mammary Carcinoma in Rats With Reference to Glycoprotein Components, Lysosomal, and Marker Enzymes

Nandhakumar¹,

Parameswaran²,

Panchanatham

2017

Asian J Pharm Clin Res

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Objectives:The aim is to evaluate the anticancer potential of Annona squamosa (AS) against 7, 12-dimethylbenz(a)anthracene (DMBA)-induced mammary carcinoma in rats. Methods:The tumor was induced in Sprague-Dawley rats by gastric intubation of 25 mg DMBA in 1 ml olive oil. After 3 months of induction period, the methanolic extract of AS at different doses of 100, 150, 200, 250, and 300 mg/kg body weight were administered orally a dose per day to mammary carcinoma-bearing rats for 45 days. The serum and tissue levels of glycoprotein components as well as the activities of marker enzymes and lysosomal enzymes were measured in DMBA-induced mammary carcinoma-bearing rats.Results: Administration of AS resulted in decrease in the levels of marker and lysosomal enzymes and also alterations in the body weight and tumor volume were also restored to near normalcy in a dose-dependent manner. The results of the present study indicate that AS has anticancer effect and it exhibits its potential effect at the dosage of 200 mg/kg body weight in mammary carcinoma-bearing rats. Conclusions:Based on the results obtained, it can be concluded that the methanol extract of AS possesses anticancer properties. Further study is needed to isolate the active principle of this extract responsible for anticancer activity to develop the future pharmaceuticals.

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γ-Glutamyl transferase and breast cancer risk

Cited by 47 publications

References 20 publications

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Study of Serum Lactate Dehydrogenase and Gamma-Glutamyl Transpeptidase in Breast Cancer Patients receiving Chemotherapy

Associations of serum uric acid and gamma-glutamyltransferase with cancer in the Vorarlberg Health Monitoring and Promotion Programme (VHM&PP) – a short review

Anticancer Effect of Methanolic Extract of Annona Squamosa on Mammary Carcinoma in Rats With Reference to Glycoprotein Components, Lysosomal, and Marker Enzymes

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