γ-Glutamyl Transferase Activity and the Burden of Coronary Atherosclerosis in Patients With ST-Segment Elevation Myocardial Infarction

Baktır, Ahmet Oğuz; Şarlı, Bahadır; Demirci, Erkan; Sağlam, Hilal; Kurtul, Serkan; Şahin, Ömer; Demirbaş, Melih; Arınç, Hüseyin

doi:10.1177/0003319713507475

Cited by 5 publications

(7 citation statements)

References 31 publications

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“…The Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery (SYNTAX) score (SS) has emerged as a tool to objectively quantify CAD complexity from an anatomical point of view, offering prognostic information and guidance concerning the appropriate coronary revascularisation method [ 2 ]. Since its introduction, SS has also been used as a method to provide objective and reproducible anatomical information about the extent of CAD [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score

et al. 2017

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Background We need new biomarkers that can predict cardiovascular disease to improve both diagnosis and therapeutic strategies. The CIRCULATING CELLS study was designed to study the role of several cellular mediators of atherosclerosis as biomarkers of coronary artery disease (CAD). An objective and reproducible method for the quantification of CAD extension is required to establish relationships with these potential biomarkers. We sought to analyse the correlation of the SYNTAX score with known CAD risk factors to test it as a valid marker of CAD extension. Methods and results A subgroup of 279 patients (67.4% males) were included in our analysis. Main exclusion criteria were a history of previous percutaneous coronary intervention or surgical revascularisation that prevent an accurate assessment of the SS. Diabetes mellitus, smoking, renal insufficiency, body mass index and a history of CAD and myocardial infarction were all positively and strongly associated with a higher SYNTAX score after adjustment for the non-modifiable biological factors (age and sex). In the multivariate model, age and male sex, along with smok- Conclusion In a selected cohort of revascularisation-naive patients with CAD undergoing coronary angiography, nonmodifiable cardiovascular risk factors such as advanced age, male sex, as well as smoking and renal failure were independently associated with CAD complexity assessed by the SYNTAX score. The SYNTAX score may be a valid marker of CAD extension to establish relationships with potential novel biomarkers of coronary atherosclerosis.

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Section: Introductionmentioning

confidence: 99%

Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score

et al. 2017

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“…In another study performed by Baktır et al (29), the relation between GGT activity and coronary atherosclerotic load was investigated in patients with STEMI and a high SYNTAX score, and no significant correlation was found between high SYNTAX score, major cardiovascular events and GGT activity. The SYNTAX score is a known useful angiographic scoring system which gives important information regarding the complexity and extensiveness of coronary lesions (24, 29).…”

Section: Discussionmentioning

confidence: 99%

“…The SYNTAX score is a known useful angiographic scoring system which gives important information regarding the complexity and extensiveness of coronary lesions (24, 29). …”

Section: Discussionmentioning

confidence: 99%

Comparison of the effects of metoprolol or carvedilol on serum gamma-glutamyltransferase and uric acid levels among patients with acute coronary syndrome without ST segment elevation

Aşkın

Karakelleoğlu²,

Değirmenci³

et al. 2015

Anatol J Cardiol

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Objective:Serum gamma-glutamyltransferase (GGT) and uric acid levels measured in patients with acute coronary syndrome without ST segment elevation (NSTEMI) are important in diagnosis and in predicting the prognosis of the disease. There is a limited number of clinical studies investigating the effects of beta-blockers on GGT and uric acid levels in these patients. In our study, we aimed to investigate the effects of beta-blocker therapy on GGT and uric acid levels.Methods:We conducted a randomized, prospective clinical study. Hundred patients with NSTEMI were included in this study, and they were divided into two groups. Fifty patients were administered metoprolol succinate treatment (1 × 50 mg), whereas the remaining 50 patients were administered carvedilol treatment (2 × 12.5 mg). Thereafter, all of the patients underwent coronary angiography. Blood samples were taken at the time of admission, at the 1st month, and 3rd month to detect GGT and uric acid levels.Results:There was no statistically significant difference among the metoprolol or carvedilol groups in terms of the GGT levels measured at the baseline, 1st month, and 3rd month (p=0.904 and p=0.573, respectively). In addition, there was no statistically significant difference among the metoprolol or carvedilol groups in terms of uric acid levels measured at the baseline, 1st month, and 3rd month (p=0.601 and p=0.601, respectively).Conclusion:We found that GGT and uric acid levels did not show any change compared to the baseline values, with metoprolol and carvedilol treatment initiated in the early period in patients with NSTEMI.

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“…In addition, an increased SXscore has been shown to be an independent predictor of major adverse cardiac events in patients with ACS (14). Various biochemical markers including the mean platelet volume, serum bilirubin level, and neutrophil-to-lymphocyte ratio have been shown to be associated with the SXscore in patients with ACS (9–11). The SXscore has the capability to effectively predict severity in patients with CAD (15).…”

Section: Discussionmentioning

confidence: 99%

“…Patients were classified according to their SXscore into two groups: low (SXscore ≤22) and high (SXscore >22) SXscore. An SXscore cut-off of ≤22 was defined according to the difference in treatment strategy in patients with an SXscore of ≤22, and various studies investigated the SXscore and several parameters (9–11). A coronary lesion resulting in a ≥50% luminal obstruction in vessels of ≥1.5 mm was separately scored and added to provide the SXscore and then summed to provide the overall patient SXscore.…”

Section: Methodsmentioning

confidence: 99%

Relationship between serum 25-hydroxyvitamin D levels and the SYNTAX score in patients with acute coronary syndrome

Baktır

Doğan²,

Şarlı³

et al. 2017

Anatol J Cardiol

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Objective:The extent of severity and complexity of coronary artery disease (CAD) in patients presenting with ST-segment elevation myocardial infarction (STEMI) and non-STEMI (NSTEMI) and possible correlations between serum 25-hydroxyvitamin D (25(OH)D) have not yet been adequately studied. We evaluated the relationship between 25(OH)D levels and the burden of CAD as assessed by the SYNTAX score (SXscore) in patients with acute coronary syndrome (ACS) including STEMI and NSTEMI.Methods:After exclusion, a total of 113 patients who were admitted to our hospital due to ACS and who were referred for undergoing coronary angiography were prospectively included. Their mean age was 63.3±18.5 years, and 80.5% of them were men. In total, 44.2% of the patients had NSTEMI and the remaining had STEMI. Blood samples were drawn at admission to evaluate serum 25(OH)D levels. CAD severity was assessed using the SXscore. Patients were classified as having low (SXscore ≤22) or high (SXscore >22) SXscores. Pearson’s and Spearman’s correlation coefficients were used to examine the relationship between serum 25(OH)D levels and the SXscore.Results:25(OH)D levels were significantly lower in the group with a high SXscore than in the group with a low SXscore (21.0±8.0 vs. 16.7±6.8, p=0.005). Correlation analysis showed a significant correlation between 25(OH)D levels and the SXscore. Multiple linear regression (MLR) analysis was used to determine the significance of the relationship between the SXscore and 25(OH)D, parathyroid hormone, and C-reactive protein levels and eGFR. MLR analysis revealed that only 25(OH)D levels (coefficient beta, -0.217, p=0.029) was significantly associated with the severity of CAD.Conclusion:The present study showed that serum 25(OH)D levels were significantly lower in patients with STEMI/NSTEMI and that low serum 25(OH)D levels were significantly correlated with CAD severity and extent. (Anatol J Cardiol 2017; 17: 293-7)

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γ-Glutamyl Transferase Activity and the Burden of Coronary Atherosclerosis in Patients With ST-Segment Elevation Myocardial Infarction

Cited by 5 publications

References 31 publications

Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score

Classical determinants of coronary artery disease as predictors of complexity of coronary lesions, assessed with the SYNTAX score

Comparison of the effects of metoprolol or carvedilol on serum gamma-glutamyltransferase and uric acid levels among patients with acute coronary syndrome without ST segment elevation

Relationship between serum 25-hydroxyvitamin D levels and the SYNTAX score in patients with acute coronary syndrome

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