γ-Cyclodextrin metal-organic frameworks as the promising carrier for pulmonary delivery of cyclosporine A

Huang, Yongpeng; Tang, Hui; Meng, Xiangyan; Liu, Dongxin; Liu, Yanli; Chen, Bo; Zou, Zhiyun

doi:10.1016/j.biopha.2024.116174

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…The SLF was developed in accordance with the published literature, 30 which was made up of 0.01% dipalmitoylphosphatidylcholine, 0.19 g/L Glycine, 0.16 g/L Na 3 citrate·2H 2 O, 0.12 g/L NH 4 Cl, 0.15 g/L Na 2 HPO 4 , 0.18 g/L Na 2 SO 4 ·10H 2 O, 0.10 g/L MgCl 2 , 2.70 g/L NaHCO 3 , 6.40 g/L NaCl and 0.26 g/L CaCl 2 ·2H 2 O.…”

Section: Methodsmentioning

confidence: 99%

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Huang,

Tang,

Meng

et al. 2024

IJN

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Introduction Nanoparticles have the advantages of improving the solubility of poorly water-soluble drugs, facilitating the drug across biological barriers, and reducing macrophage phagocytosis in pulmonary drug delivery. However, nanoparticles have a small aerodynamic particle size, which makes it difficult to achieve optimal deposition when delivered directly to the lungs. Therefore, delivering nanoparticles to the lungs effectively has become a popular research topic. Methods Nanoaggregate microparticles were used as a pulmonary drug delivery strategy for the improvement of the bioavailability of cyclosporine A (CsA). The nanoaggregate microparticles were prepared with polyvinyl pyrrolidone (PVP) as the excipient by combining the anti-solvent method and spray drying process. The physicochemical properties, aerodynamic properties, in vivo pharmacokinetics and inhalation toxicity of nanoaggregate microparticles were systematically evaluated. Results The optimal nanoparticles exhibited mainly spherical shapes with the particle size and zeta potential of 180.52 nm and −19.8 mV. The nanoaggregate microparticles exhibited irregular shapes with the particle sizes of less than 1.6 µm and drug loading (DL) values higher than 70%. Formulation NM-2 as the optimal nanoaggregate microparticles was suitable for pulmonary drug delivery and probably deposited in the bronchiole and alveolar region, with FPF and MMAD values of 89.62% and 1.74 μm. In addition, inhaled NM-2 had C max and AUC 0-∞ values approximately 1.7-fold and 1.8-fold higher than oral cyclosporine soft capsules (Neoral ® ). The inhalation toxicity study suggested that pulmonary delivery of NM-2 did not result in lung function damage, inflammatory responses, or tissue lesions. Conclusion The novel nanoaggregate microparticles for pulmonary drug delivery could effectively enhance the relative bioavailability of CsA and had great potential for clinical application.

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Section: Methodsmentioning

confidence: 99%

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Huang,

Tang,

Meng

et al. 2024

IJN

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“…4 Metal−organic framework (MOF) crystalline materials have good optical properties due to their unique characteristics of diverse structure, large specific surface area, tunable pore size, and abundant active sites on the pore surface that are easy to be functionalized. 5,6 They have potential applications in gas separation and adsorption, 7 heterogeneous catalysis, 8 biological imaging, 9 drug delivery, 10 and fluorescence sensing. 11,12 In general, the variable metal centers and organic ligands of MOF materials result in structural and functional diversity.…”

Section: Introductionmentioning

confidence: 99%

“…The current research has yielded a diverse range of materials , for the adsorption and detection of environmental pollutants, with fluorescence sensing materials being highly favored due to their exceptional attributes of superior selectivity and ultralow detection limits . Metal–organic framework (MOF) crystalline materials have good optical properties due to their unique characteristics of diverse structure, large specific surface area, tunable pore size, and abundant active sites on the pore surface that are easy to be functionalized. , They have potential applications in gas separation and adsorption, heterogeneous catalysis, biological imaging, drug delivery, and fluorescence sensing. , In general, the variable metal centers and organic ligands of MOF materials result in structural and functional diversity. Compared with the commonly used transition metal center elements, rare earth elements are more susceptible to sensitization effects during the transfer process due to their unique 4f-orbital electrons in lanthanide metal–organic frameworks (Ln-MOFs) and can lead to an increase in their Stokes shifts and higher quantum yields .…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Lanthanide Metal–Organic Frameworks Are Used for Fluorescence Sensing of Bi³⁺, HPO₄^2–, Flu, and PNBA and Application

Sun,

Liu,

Cui

et al. 2024

Inorg. Chem.

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Using a nitrogen-containing tricarboxylic acid ligand (imidazole-1yl) benzene-2,4,6-tricarboxylic acid (H 3 ttc) and lanthanide metal elements (Dy, Eu, Nd, and Gd), four lanthanide metal organic frameworks (Ln-MOFs) with the same structure, namely, {[Dy 2 (Httc) 4), were synthesized under solvothermal conditions. The characterization analysis showed that the four isomorphic Ln-MOFs were trigonal crystals of the R3̅ c space group, with good phase purity and thermal stability. Fluorescence analysis showed that complex 1 can be an excellent fluorescence sensor for Bi 3+ , HPO 4 2− , and fluridine (Flu), while complex 2 can be an excellent fluorescence sensor for p-nitrobenzoic acid (PNBA). And their sensing mechanisms were discussed in detail. The fluorescent test paper and fluorescent seal were prepared by using the excellent luminescence properties of 1 and 2, and the pesticide on the surface of cherry tomato was detected. The applicability of these MOFs as fluorescence sensors was proved. Therefore, Ln-MOFs are expected to have unpredictable application prospects in the field of environmental detection.

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Cyclodextrin-based metal-organic frameworks transforming drug delivery

Yang,

Wei,

Teng

et al. 2024

European Journal of Medicinal Chemistry

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γ-Cyclodextrin metal-organic frameworks as the promising carrier for pulmonary delivery of cyclosporine A

Cited by 4 publications

References 46 publications

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Multifunctional Lanthanide Metal–Organic Frameworks Are Used for Fluorescence Sensing of Bi³⁺, HPO₄^2–, Flu, and PNBA and Application

Cyclodextrin-based metal-organic frameworks transforming drug delivery

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γ-Cyclodextrin metal-organic frameworks as the promising carrier for pulmonary delivery of cyclosporine A

Cited by 4 publications

References 46 publications

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Highly Drug-Loaded Nanoaggregate Microparticles for Pulmonary Delivery of Cyclosporin A

Multifunctional Lanthanide Metal–Organic Frameworks Are Used for Fluorescence Sensing of Bi3+, HPO42–, Flu, and PNBA and Application

Cyclodextrin-based metal-organic frameworks transforming drug delivery

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Multifunctional Lanthanide Metal–Organic Frameworks Are Used for Fluorescence Sensing of Bi³⁺, HPO₄^2–, Flu, and PNBA and Application